Inhibitory neurophysiological deficit as a phenotype for genetic investigation of schizophrenia

"Cognitive Dysmetria" as an Integrative Theory of Schizophrenia: A Dysfunction in Cortical-Subcortical-Cerebellar Circuitry?

1998 • 1,145 citations

Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus

1997 • 1,142 citations

Neurophysiological evidence for a defect in neuronal mechanisms involved in sensory gating in schizophrenia.

1982 • 888 citations

Hippocampal Volume Reduction in Schizophrenia as Assessed by Magnetic Resonance Imaging

1998 • 753 citations

Normalization of auditory physiology by cigarette smoking in schizophrenic patients

1993 • 689 citations

Impaired Attention, Genetics, and the Pathophysiology of Schizophrenia

1994 • 671 citations

Limbic System Abnormalities Identified in Schizophrenia Using Positron Emission Tomography With Fluorodeoxyglucose and Neocortical Alterations With Deficit Syndrome

1992 • 546 citations

Schizophrenia susceptibility loci on chromosomes 13q32 and 8p21

1998 • 542 citations

Normalization by nicotine of deficient auditory sensory gating in the relatives of schizophrenics

1992 • 417 citations

Neuropsychological Assessment of Monozygotic Twins Discordant for Schizophrenia

1990 • 387 citations

Acetylcholine Activates an α-Bungarotoxin-Sensitive Nicotinic Current in Rat Hippocampal Interneurons, But Not Pyramidal Cells

1998 • 380 citations

Neuropsychological Functioning in Siblings Discordant for Schizophrenia and Healthy Volunteers

1994 • 355 citations

Genetics and Child Psychiatry: II Empirical Research Findings

1999 • 292 citations

A Single Dominant Gene Can Account for Eye Tracking Dysfunctions and Schizophrenia in Offspring of Discordant Twins

1988 • 275 citations

NIMH genetics initiative millennium schizophrenia consortium: Linkage analysis of African-American pedigrees

1998 • 269 citations

Cholinergic gating of response to auditory stimuli in rat hippocampus

1992 • 264 citations

Sensory gating deficits in schizophrenia: new results

1992 • 263 citations

Sensory gating in schizophrenics and normal controls: Effects of changing stimulation interval

1989 • 258 citations

Genetic Analysis of an Inherited Predisposition to Colon Cancer in a Family with a Variable Number of Adenomatous Polyps

1990 • 254 citations

Increased levels of the nicotine metabolite cotinine in schizophrenic smokers compared to other smokers

1997 • 252 citations

Genomic Organization and Partial Duplication of the Human α7 Neuronal Nicotinic Acetylcholine Receptor Gene (CHRNA7)

1998 • 239 citations

Suggestive Evidence for a Schizophrenia Susceptibility Locus on Chromosome 6q and a Confirmation in an Independent Series of Pedigrees

1997 • 234 citations

Comparison of the regional expression of nicotinic acetylcholine receptor ?7 mRNA and [125I]-?-bungarotoxin binding in human postmortem brain

1997 • 233 citations

Auditory sensory gating in hippocampal neurons: A model system in the rat

1990 • 225 citations

Schizophrenia and Nicotinic Receptors

1994 • 224 citations

Neurophysiological and neuropsychological evidence for attentional dysfunction in schizophrenia

1993 • 213 citations

Alpha-bungarotoxin binding to hippocampal interneurons: immunocytochemical characterization and effects on growth factor expression

1993 • 205 citations

Genetic Correlation of Inhibitory Gating of Hippocampal Auditory Evoked Response and α-Bungarotoxin-Binding Nicotinic Cholinergic Receptors in Inbred Mouse Strains

1996 • 202 citations

Heterogeneity of Schizophrenia

1990 • 198 citations

Replication and Extension of P50 Findings in Schizophrenia

1991 • 190 citations

Eye tracking dysfunction is a putative phenotypic susceptibility marker of schizophrenia and maps to a locus on chromosome 6p in families with multiple occurrence of the disease

1996 • 185 citations

Initial genomic scan of the NIMH genetics initiative bipolar pedigrees: Chromosomes 3, 5, 15, 16, 17, and 22

1997 • 165 citations

P50 abnormalities in schizophrenia: relationship to clinical and neuropsychological indices of attention

1998 • 149 citations

Sensory physiology and catecholamines in schizophrenia and mania

1990 • 141 citations

Improvement in Smooth Pursuit Eye Movements after Cigarette Smoking in Schizophrenic Patients

1998 • 138 citations

The activity of hippocampal interneurons and pyramidal cells during the response of the hippocampus to repeated auditory stimuli

1995 • 130 citations

Further investigation of a chromosome 15 locus in schizophrenia: Analysis of affected sibpairs from the NIMH genetics initiative

1998 • 129 citations

Auditory sensory gating, hippocampal volume, and catecholamine metabolism in schizophrenics and their siblings

1994 • 122 citations

P50 suppression in recent-onset schizophrenia: Clinical correlates and risperidone effects.

1998 • 121 citations

A Linkage Study of Bipolar Illness

1997 • 118 citations

Effects of P50 temporal variability on sensory gating in schizophrenia

1997 • 114 citations

Multiple site evaluation of P50 suppression among schizophrenia and normal comparison subjects

1998 • 114 citations

Sensory gating deficits in psychiatric impatients: Relation to catecholamine metabolites in different diagnostic groups

1990 • 114 citations

Midlatency auditory evoked responses in schizophrenia

1991 • 113 citations

Molecular Cloning and Chromosomal Localization of the Human α7-Nicotinic Receptor Subunit Gene (CHRNA7)

1994 • 99 citations

P50 suppression in recent-onset schizophrenia: Clinical correlates and risperidone effects.

1998 • 96 citations

Childhood-Onset Schizophrenia: Timely Neurobiological Research

1994 • 94 citations

Prader-Willi Syndrome and Psychoses

1993 • 84 citations

GABAB antagonists diminish the inhibitory gating of auditory response in the rat hippocampus

1995 • 81 citations

The gene responsible for a severe form of peripheral neuropathy and agenesis of the corpus callosum maps to chromosome 15q.

1996 • 78 citations

Neuropsychological dysfunction in parents of schizophrenics

1996 • 78 citations

The New York High-Risk Project: attention, anhedonia and social outcome

1998 • 78 citations

Anticipatory saccades during smooth pursuit eye movements and familial transmission of schizophrenia

1998 • 77 citations

Sensory gating deficits in parents of schizophrenics

1995 • 73 citations

Medial septal neuron activity in relation to an auditory sensory gating paradigm

1993 • 69 citations

No evidence for linkage between schizophrenia and markers at chromosome 15q13-14

1999 • 66 citations

Auditory sensory gating in the rat hippocampus: modulation by brainstem activity

1993 • 65 citations

Brief research communication: No evidence for linkage of the CHRNA7 gene region in Canadian schizophrenia families

1998 • 64 citations

Replication of a P50 auditory gating deficit in Australian patients with schizophrenia

1996 • 60 citations

Use of a neurophysiological trait in linkage analysis of schizophrenia

1993 • 58 citations

Evidence for bilineal inheritance of physiological indicators of risk in childhood-onset schizophrenia

1999 • 56 citations

Effects of sound intensity on a midlatency evoked response to repeated auditory stimuli in schizophrenic and normal subjects

1995 • 55 citations

Restoration of sensory gating of auditory evoked response by nicotine in fimbria-fornix lesioned rats

1995 • 54 citations

Ventricular enlargement associated with linkage marker for schizophrenia-related disorders in one pedigree.

1996 • 30 citations

Schizophrenia and Marfan Syndrome

1990 • 30 citations

Psychiatric disorder in a familial 15;18 translocation and sublocalization of myelin basic protein to 18q22.3

1996 • 22 citations

Reaction Time Crossover as a Marker of Schizophrenia and of Higher Functioning

1986 • 21 citations

Segregation analysis of complex phenotypes

1994 • 19 citations

Inhibition of nitric oxide synthase disrupts inhibitory gating of auditory responses in rat hippocampus.

1998 • 16 citations

Serum Ferritin as a Marker of Affection for Genetic Hemochromatosis

1990 • 11 citations

P50 suppression deficits among the relatives of schizophrenia patients

1997 • 6 citations