Ovarian Hormones Elicit Phosphorylation of Akt and Extracellular-Signal Regulated Kinase in Explants of the Cerebral Cortex

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

1997 • 5,665 citations

Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

1995 • 4,589 citations

Cellular survival: a play in three Akts

1999 • 4,229 citations

Serine Phosphorylation of Death Agonist BAD in Response to Survival Factor Results in Binding to 14-3-3 Not BCL-XL

1996 • 2,627 citations

Regulation of Neuronal Survival by the Serine-Threonine Protein Kinase Akt

1997 • 2,442 citations

Bad, a heterodimeric partner for Bcl-xL and Bcl-2, displaces bax and promotes cell death

1995 • 2,114 citations

PI3K: Downstream AKTion Blocks Apoptosis

1997 • 1,693 citations

Effect of oestrogen during menopause on risk and age at onset of Alzheimer's disease

1996 • 1,640 citations

Activation of Mitogen-activated Protein Kinase by H2O2

1996 • 1,202 citations

Tyrosine kinase/p21ras/MAP-kinase pathway activation by estradiol-receptor complex in MCF-7 cells.

1996 • 964 citations

Integration of MAP Kinase Signal Transduction Pathways at the Serum Response Element

1995 • 935 citations

Organotypic monolayer cultures of nervous tissue

1981 • 862 citations

Estrogens Attenuate and Corticosterone Exacerbates Excitotoxicity, Oxidative Injury, and Amyloid β‐Peptide Toxicity in Hippocampal Neurons

1996 • 833 citations

Role and regulation of 90 kDa ribosomal S6 kinase (RSK) in signal transduction

1999 • 722 citations

Estrogen action via the cAMP signaling pathway: stimulation of adenylate cyclase and cAMP-regulated gene transcription.

1994 • 667 citations

17-β Estradiol Protects Neurons from Oxidative Stress-Induced Cell Death in Vitro

1995 • 612 citations

The Mitogen-Activated Protein Kinase Pathway Mediates Estrogen Neuroprotection after Glutamate Toxicity in Primary Cortical Neurons

1999 • 581 citations

Identification of a putative estrogen response element in the gene encoding brain-derived neurotrophic factor.

1995 • 542 citations

Estrogens may reduce mortality and ischemic damage caused by middle cerebral artery occlusion in the female rat

1997 • 512 citations

Nerve Growth Factor Activates Extracellular Signal-Regulated Kinase and p38 Mitogen-Activated Protein Kinase Pathways To Stimulate CREB Serine 133 Phosphorylation

1998 • 495 citations

Ovarian steroid deprivation results in a reversible learning impairment and compromised cholinergic function in female Sprague-Dawley rats

1994 • 487 citations

Estrogen-Induced Activation of Mitogen-Activated Protein Kinase in Cerebral Cortical Explants: Convergence of Estrogen and Neurotrophin Signaling Pathways

1999 • 474 citations

Estradiol Enhances Learning and Memory in a Spatial Memory Task and Effects Levels of Monoaminergic Neurotransmitters

1998 • 441 citations

Transcriptional regulation by MAP kinases

1995 • 431 citations

The effect of ovariectomy and estradiol replacement on brain-derived neurotrophic factor messenger ribonucleic acid expression in cortical and hippocampal brain regions of female Sprague-Dawley rats.

1995 • 422 citations

A new, nongenomic estrogen action: the rapid release of intracellular calcium.

1992 • 372 citations

Sex steroids and the development of the newborn mouse hypothalamus and preoptic areain vitro: implications for sexual differentiation

1976 • 372 citations

Age-related Decline in Mitogen-activated Protein Kinase Activity in Epidermal Growth Factor-stimulated Rat Hepatocytes

1996 • 351 citations

Extracellular Signal-Regulated Kinase (ERK) Controls Immediate Early Gene Induction on Corticostriatal Stimulation

1998 • 335 citations

Estrogen protects primary cortical neurons from glutamate toxicity

1996 • 329 citations

Progesterone Facilitates Cognitive Recovery and Reduces Secondary Neuronal Loss Caused by Cortical Contusion Injury in Male Rats

1994 • 319 citations

Progesterone protects against lipid peroxidation following traumatic brain injury in rats

1997 • 315 citations

Glutamate Induces Phosphorylation of Elk-1 and CREB, Along with c -fos Activation, via an Extracellular Signal-Regulated Kinase-Dependent Pathway in Brain Slices

1999 • 310 citations

Insulin-Like Growth Factor and Potassium Depolarization Maintain Neuronal Survival by Distinct Pathways: Possible Involvement of PI 3-Kinase in IGF-1 Signaling

1997 • 294 citations

The tyrosine kinase and mitogen-activated protein kinase pathways mediate multiple effects of estrogen in hippocampus

2000 • 274 citations

Estrogen-induced activation of the mitogen-activated protein kinase cascade in the cerebral cortex of estrogen receptor-alpha knock-out mice.

2000 • 247 citations

Phosphatidylinositol 3-kinase mediates neuroprotection by estrogen in cultured cortical neurons

2000 • 242 citations

Estradiol protects against β-amyloid (25–35)-induced toxicity in SK-N-SH human neuroblastoma cells

1996 • 238 citations

Co-regulation of the mitogen-activated protein kinase, extracellular signal-regulated kinase 1, and the 90-kDa ribosomal S6 kinase in PC12 cells. Distinct effects of the neurotrophic factor, nerve growth factor, and the mitogenic factor, epidermal growth factor

1993 • 224 citations

Nerve growth factor induces survival and differentiation through two distinct signaling cascades in PC12 cells

1999 • 221 citations

Control of transcription activation by steroid hormone receptors

1992 • 218 citations

Testosterone increases and estradiol decreases middle cerebral artery occlusion lesion size in male rats

1998 • 187 citations

Estradiol Increases Spine Density and NMDA-Dependent Ca²⁺Transients in Spines of CA1 Pyramidal Neurons From Hippocampal Slices

1999 • 177 citations

Sex steroids and the development of the newborn mouse hypothalamus and preoptic area in vitro. II. Morphological correlates and hormonal specificity

1980 • 176 citations

Transcriptional Effects of Estrogen on Neuronal Neurotensin Gene Expression Involve cAMP/Protein Kinase A-Dependent Signaling Mechanisms

1998 • 171 citations

Prevention of PC12 Cell Death byN-Acetylcysteine Requires Activation of the Ras Pathway

1998 • 162 citations

New concepts in steroid hormone action: transcription factors, proto-oncogenes, and the cascade model for steroid regulation of gene expression.

1992 • 152 citations

Estrogenic stimulation of neurite growth in midbrain dopaminergic neurons depends on cAMP/protein kinase A signalling

2000 • 136 citations

Low concentrations of estradiol reduce β-amyloid (25–35)-induced toxicity, lipid peroxidation and glucose utilization in human SK-N-SH neuroblastoma cells

1997 • 133 citations

Regulation of Amyloid Precursor Protein Catabolism Involves the Mitogen-Activated Protein Kinase Signal Transduction Pathway

1997 • 133 citations

Steroid hormone receptors and steroid action in rat glial cells of the central and peripheral nervous system

1998 • 109 citations

Regulation of Secretion of Alzheimer Amyloid Precursor Protein by the Mitogen‐Activated Protein Kinase Cascade

1998 • 109 citations

Protection Against Oxidative Stress‐induced Neuronal Cell Death‐A Novel Role for RU486

1997 • 100 citations

Progesterone receptor and the mechanism of action of progesterone antagonists

1995 • 87 citations

Progesterone facilitates the acquisition of avoidance learning and protects against subcortical neuronal death following prefrontal cortex ablation in the rat

1998 • 84 citations

Progesterone as a neurosteroid: synthesis and actions in rat glial cellsProceedings of Xth International Congress on Hormonal Steroids, Quebec, Canada, 17–21 June 1998.

1999 • 72 citations

Cellular components of nerve growth factor signaling

1994 • 57 citations

Two Types of Anti-progestins Have Distinct Effects on Site-specific Phosphorylation of Human Progesterone Receptor

1996 • 55 citations

17beta-estradiol attenuates CREB decline in the rat hippocampus following seizure.

1997 • 39 citations

Reductions in brain phosphatidylinositol kinase activities in alzheimer’s disease

1999 • 35 citations

Acute modulation of Ca2+ influx on rat heart by 17β-estradiol

2000 • 31 citations

Gene activation pathways of nerve growth factor signaling: a minireview.

1996 • 19 citations