The neuroprotective effect of cerebral poly(ADP-ribose)polymerase inhibition in a rat model of global ischemia

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Nitric Oxide Activation of Poly(ADP-Ribose) Synthetase in Neurotoxicity

1994 • 1,138 citations

Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia

1997 • 1,020 citations

The density and distribution of ischemic brain injury in the rat following 2?10 min of forebrain ischemia

1984 • 968 citations

Poly(ADP-Ribose) in the Cellular Response to DNA Damage

1985 • 771 citations

DNA strand breakage, activation of poly (ADP-ribose) synthetase, and cellular energy depletion are involved in the cytotoxicity of macrophages and smooth muscle cells exposed to peroxynitrite.

1996 • 630 citations

Ischemic Brain Injury is Mediated by the Activation of Poly(ADP-Ribose)Polymerase

1997 • 624 citations

Hydrogen peroxide-induced injury of cells and its prevention by inhibitors of poly(ADP-ribose) polymerase.

1986 • 466 citations

Inhibition of the activity of poly(ADP ribose) synthetase reduces ischemia–reperfusion injury in the heart and skeletal muscle

1997 • 310 citations

Inactivation of the Poly(ADP-ribose) Polymerase Gene Affects Oxygen Radical and Nitric Oxide Toxicity in Islet Cells

1995 • 270 citations

Inhibitors of Poly(Adenosine Diphosphate-Ribose) Synthesis: Effect on Other Metabolic Processes

1984 • 241 citations

Protection against myocardial ischemia and reperfusion injury by 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase

1997 • 225 citations

Nitric Oxide Toxicity in Islet Cells Involves Poly(ADP-Ribose) Polymerase Activation and Concomitant NAD+ Depletion

1994 • 188 citations

Reactive oxygen injury to cultured pulmonary artery endothelial cells: Mediation by poly(ADP-ribose) polymerase activation causing NAD depletion and altered energy balance

1991 • 156 citations

Poly(ADP‐ribose) polymerase: Early involvement in glutamate‐induced neurotoxicity in cultured cerebellar granule cells

1994 • 122 citations

Enhanced Poly(ADP-ribosyl)ation after Focal Ischemia in Rat Brain

1998 • 113 citations

Neuroprotection against nitric oxide injury with inhibitors of ADP-ribosylation.

1993 • 63 citations

Neuroprotection against nitricf oxide injury with inhibitors of ADP-ribosylation

1993 • 53 citations

Effects of inhibitors of the activity of poly (ADP‐ribose) synthetase on the liver injury caused by ischaemia‐reperfusion: a comparison with radical scavengers

1998 • 43 citations

Interrelation between cerebral energy metabolism and behaviour in a rat model of permanent brain vessel occlusion

1999 • 42 citations

Role of peroxynitrite and activation of poly (ADP‐ribose) synthetase in the vascular failure induced by zymosan‐activated plasma

1997 • 42 citations

Nucleotide Depletion Due to Reactive Oxygen Metabolites in Endothelial Cells: Effects of Antioxidants and 3-Aminobenzamide

1993 • 33 citations

Increased ATP production during long-term brain ischemia in rats in the presence of propentofylline

1998 • 11 citations

Detection of heterogeneity of apoptotic fragments of poly (ADP-ribose) polymerase in MDA-MB-468 breast cancer cells: Two-dimensional gel analysis

1999 • 6 citations