Molecular mechanics of nucleic acid sequence amplification

The Selfish Gene

1976 • 10,856 citations

Enzymatic Amplification of β-Globin Genomic Sequences and Restriction Site Analysis for Diagnosis of Sickle Cell Anemia

1985 • 9,128 citations

Complete nucleotide sequence of bacteriophage T7 DNA and the locations of T7 genetic elements

1983 • 1,316 citations

Nucleic acid sequence-based amplification

1991 • 1,287 citations

Identification of the Uncultured Bacillus of Whipple’s Disease

1992 • 1,143 citations

Simultaneous Amplification and Detection of Specific DNA Sequences

1992 • 1,108 citations

Recent Advances in the Polymerase Chain Reaction

1991 • 1,068 citations

Effects of primer-template mismatches on the polymerase chain reaction: Human immunodeficiency virus type 1 model studies

1990 • 1,037 citations

A Common Language for Physical Mapping of the Human Genome

1989 • 876 citations

A Ligase-Mediated Gene Detection Technique

1988 • 834 citations

Strand displacement amplification—an isothermal,in vitroDNA amplification technique

1992 • 794 citations

Directed Evolution of an RNA Enzyme

1992 • 451 citations

PROTEIN-PRIMING OF DNA REPLICATION

1991 • 387 citations

Studies on polynucleotides

1971 • 350 citations

Specificity of the nick-closing activity of bacteriophage T4 DNA ligase

1989 • 163 citations

In vitro genetics

1992 • 159 citations

Evolution in vitro: Sequence and phenotype of a mutant RNA resistant to ethidium bromide

1974 • 138 citations

A biochemical perspective of the polymerase chain reaction

1991 • 135 citations

Selection of a Ribozyme That Functions as a Superior Template in a Self-Copying Reaction

1992 • 126 citations

Autocatalytic replication of a recombinant RNA

1983 • 81 citations

Quantitative assays based on the use of replicatable hybridization probes.

1989 • 77 citations

Self-Replicating Systems.

1992 • 41 citations

A noise-free molecular hybridization procedure for measuring RNA in cell lysates

1989 • 22 citations

Exonuclease cycling assay: an amplified assay for the detection of specific DNA sequences.

1992 • 3 citations