Back to search

Combined Use of the Adenosine A2A Antagonist KW-6002 with l-DOPA or with Selective D1 or D2 Dopamine Agonists Increases Antiparkinsonian Activity but Not Dyskinesia in MPTP-Treated Monkeys

Data up to Jan 2025

Published2000
Citations248
References37

Total Citations Per Year

Abstract

References (37)

Nomenclature and classification of purinoceptors.

1994 • 1,569 citations

Biochemical pathophysiology of Parkinson's disease.

1987 • 844 citations

Characterization of the A2 adenosine receptor labeled by [3H]NECA in rat striatal membranes.

1986 • 821 citations

Striatal Restricted Adenosine A2 Receptor (RDC8) Is Expressed by Enkephalin but Not by Substance P Neurons: An In Situ Hybridization Histochemistry Study

1991 • 527 citations

Amantadine as treatment for dyskinesias and motor fluctuations in Parkinson's disease

1998 • 504 citations

Subclasses of adenosine receptors in the central nervous system: Interaction with caffeine and related methylxanthines

1983 • 437 citations

Adenosine A2A Antagonist: A novel antiparkinsonian agent that does not provoke dyskinesia in Parkinsonian monkeys

1998 • 359 citations

Direct autoradiographic localization of adenosine A2 receptors in the rat brain using the A2-selective agonist, [3H]CGS 21680

1989 • 344 citations

Entacapone improves motor fluctuations in levodopa‐ treated Parkinson's disease patients

1997 • 295 citations

Overview of morphological changes in Parkinson's disease.

1987 • 275 citations

Adenosine A2A receptor antagonists as new agents for the treatment of Parkinson's disease

1997 • 264 citations

Chronic <scp>L</scp>‐DOPA administration induces dyskinesias in the 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine‐treated common marmoset (Callithrix jacchus)

1995 • 215 citations

Adenosine A2 receptors: Selective localization in the human basal ganglia and alterations with disease

1991 • 198 citations

Distribution of adenosine A2 receptor mRNA in the human brain

1991 • 173 citations

Action of caffeine and theophyllamine on supersensitive dopamine receptors: considerable enhancement of receptor response to treatment with DOPA and dopamine receptor agonists.

1974 • 166 citations

Pathogenesis of dyskinesias in parkinson's disease

1989 • 151 citations

The Role of Adenosine A2a Receptors in Regulating Gabaergic Synaptic Transmission in Striatal Medium Spiny Neurons

1996 • 143 citations

KF17837: A novel selective adenosine A2A receptor antagonist with anticataleptic activity

1994 • 142 citations

(E)-1,3-Dialkyl-7-methyl-8-(3,4,5-trimethoxystyryl)xanthines: potent and selective adenosine A2 antagonists

1992 • 138 citations

The role of adenosine A2a receptors in regulating GABAergic synaptic transmission in striatal medium spiny neurons

1996 • 137 citations

Adenosine A2A receptor antagonists as new agents for the treatment of Parkinson's disease

1997 • 129 citations

Stimulation of adenosine A2 receptors induces catalepsy

1991 • 111 citations

Inhibition by KF17837 of adenosine A2A receptor‐mediated modulation of striatal GABA and ACh release

1994 • 107 citations

Adenosine A2A receptors modify motor function in MPTP-treated common marmosets

1998 • 104 citations

Adenosine A2A antagonists with potent anti-cataleptic activity

1997 • 101 citations

Adenosine A2a Receptor‐Mediated Modulation of Striatal Acetylcholine Release In Vivo

1996 • 92 citations

KF17837 ((E)-8-(3,4-dimethoxystyryl)-1,3-dipropyl-7-methylxanthine) a potent and selective adenosine A2 receptor antagonist

1994 • 83 citations

Motor activity following the administration of selective D-1 and D-2 dopaminergic drugs to normal common marmosets

1991 • 73 citations

COMT inhibition

1998 • 65 citations

Adenosine A2 receptor regulation of apomorphine-induced turning in rats with unilateral striatal dopamine denervation

1993 • 59 citations

Striatal A2 receptor regulates apomorphine-induced turning in rats with unilateral dopamine denervation

1991 • 59 citations

Differential anti-parkinsonian effects of benzazepine D1 dopamine agonists with varying efficacies in the MPTP-treated common marmoset

1995 • 53 citations

Behavioral effects of intrastriatal caffeine mediated by adenosinergic modulation of dopamine

1991 • 50 citations

Motor activity following the administration of selective D-1 and D-2 dopaminergic drugs to MPTP-treated common marmosets

1992 • 47 citations

The effect of tolcapone on levodopa pharmacokinetics is independent of levodopa/carbidopa formulation

1998 • 34 citations

Influence of COMT inhibition on levodopa pharmacology and therapy

1998 • 24 citations

Practical Therapy of Parkinson's Disease

1987 • 11 citations

Cited By (0)

Loading...
Combined Use of the Adenosine A2A Antagonist KW-6002 with l-DOPA or with Selective D1 or… (2000) – Experimental Neurology | Metascience Observatory Explorer