Nicotinic cholinergic receptors: potential targets for inflammatory pain relief

Organization and morphological characteristics of cholonergic neurons: an immunocytochemical study with a monoclonal antibody to choline acetyltransferase

1983 • 745 citations

Epibatidine: a novel (chloropyridyl)azabicycloheptane with potent analgesic activity from an Ecuadoran poison frog

1992 • 553 citations

Further evidence for ‘pain-related’ behaviours in a model of unilateral peripheral mononeuropathy

1990 • 504 citations

The morphology and distribution of neurons containing choline acetyltransferase in the adult rat spinal cord: An immunocytochemical study

1984 • 439 citations

The pharmacology of excitatory and inhibitory amino acid-mediated events in the transmission and modulation of pain in the spinal cord

1997 • 408 citations

Epibatidine, a potent analgetic and nicotinic agonist.

1994 • 371 citations

Descending serotonergic, peptidergic and cholinergic pathways from the raphe nuclei: A multiple transmitter complex

1983 • 370 citations

Broad-Spectrum, Non-Opioid Analgesic Activity by Selective Modulation of Neuronal Nicotinic Acetylcholine Receptors

1998 • 365 citations

Comparative pharmacology of epibatidine: a potent agonist for neuronal nicotinic acetylcholine receptors.

1995 • 284 citations

Modulation of spinal excitability: co-operation between neurokinin and excitatory amino acid neurotransmitters

1994 • 266 citations

Effects of iontophoretically released amino acids and amines on primate spinothalamic tract cells

1984 • 213 citations

N-methyl-D-aspartate (NMDA) and non-NMDA receptor antagonists block the hyperexcitability of dorsal horn neurons during development of acute arthritis in rat's knee joint

1993 • 194 citations

Behavioral and immunohistochemical changes in an experimental arthritis model in rats

1993 • 185 citations

Intrathecal baclofen and muscimol, but not midazolam, are antinociceptive using the rat-formalin model.

1995 • 178 citations

Subpopulations of gabaergic neurons in laminae i–iii of rat spinal dorsal horn defined by coexistence with classical transmitters, peptides, nitric oxide synthase or parvalbumin

1994 • 175 citations

CHANGES IN CENTRAL OPIOID RECEPTOR BINDING IN RELATION TO INFLAMMATION AND PAIN IN PATIENTS WITH RHEUMATOID ARTHRITIS

1994 • 160 citations

Topography of choline acetyltransferase Immunoreactive Neurons and fibers in the rat spinal cord

1986 • 142 citations

An experimental arthritis in rats: Dorsal horn aspartate and glutamate increases

1992 • 141 citations

Characterization of nicotinic receptors involved in the release of noradrenaline from the hippocampus

1997 • 134 citations

Choline acetyltransferase‐immunoreactive profiles are presynaptic to primary sensory fibers in the rat superficial dorsal horn

1990 • 133 citations

The spinal contribution of substance P to the generation and maintenance of inflammatory hyperalgesia in the rat

1996 • 124 citations

The role of glutamate and GABA receptors in the generation of dorsal root reflexes by acute arthritis in the anaesthetized rat.

1995 • 124 citations

Do dorsal root reflexes augment peripheral inflammation?

1994 • 117 citations

Role of spinal gamma-aminobutyric acidA receptors in formalin-induced nociception in the rat.

1997 • 106 citations

Release of dopamine and 5-hydroxytryptamine from rat striatal slices following activation of nicotinic cholinergic receptors

1983 • 102 citations

Peptide neuroanatomy of adjuvant-induced arthritic inflammation in rat

1988 • 102 citations

Roles of substance P and somatostatin on transmission of nociceptive information induced by formalin in spinal cord.

1990 • 97 citations

Evaluation of anti-nociceptive effects of neuronal nicotinic acetylcholine receptor (NAChR) ligands in the rat tail-flick assay

1996 • 97 citations

Spinal cord amino acid release and content in an arthritis model: the effects of pretreatment with non-NMDA, NMDA, and NK1 receptor antagonists

1993 • 97 citations

Preproenkephalin mRNA and Methionine‐Enkephalin Content Are Increased in Mouse Striatum After Treatment with Nicotine

1995 • 84 citations

Carrageenan-induced inflammation of the hind foot provokes a rise of GABA-immunoreactive cells in the rat spinal cord that is prevented by peripheral neurectomy or neonatal capsaicin treatment

1994 • 82 citations

An experimental arthritis model in rats: The effects of NMDA and non-NMDA antagonists on aspartate and glutamate release in the dorsal horn

1993 • 82 citations

The role of dorsal root reflexes in neurogenic inflammation

1995 • 80 citations

Immunohistochemical evidence that acetylcholine and glycine exist in different populations of GABAergic neurons in lamina III of rat spinal dorsal horn

1991 • 78 citations

Antinociceptive action of nicotine and its methiodide derivatives in mice and rats

1983 • 73 citations

Inflammation-induced release of excitatory amino acids is prevented by spinal administration of a GABAA but not by a GABAB receptor antagonist in rats.

1994 • 63 citations

Autoradiographic distribution of [3H]acetylcholine binding sites in the cervical spinal cord of man and some other species

1988 • 63 citations

Differential effects of N-methyl-D-aspartate (NMDA) and non-NMDA receptor antagonists on spinal release of amino acids after development of acute arthritis in rats

1994 • 53 citations

Nicotinic acetylcholine receptors on capsaicin-sensitive nerves

1995 • 53 citations

Evidence for Nicotinic Receptors Potentially Modulating Nociceptive Transmission at the Level of the Primary Sensory Neuron: Studies with F11 Cells

1997 • 53 citations

Characterization of the electrophysiological, biochemical and behavioral actions of epibatidine.

1995 • 52 citations

Ligand specificity of nicotinic acetylcholine receptors in rat spinal cord: studies with nicotine and cytisine.

1994 • 51 citations

Intrathecal nicotinic agonist-elicited release of excitatory amino acids as measured by in vivo spinal microdialysis in rats.

1996 • 50 citations

Opioid systems in the response to inflammatory pain: Sustained blockade suggests role of κ- but not μ-opioid receptors in the modulation of nociception, behaviour and pathology

1991 • 48 citations

Epibatidine: a nicotinic acetylcholine receptor agonist releases monoaminergic neurotransmitters: in vitro and in vivo evidence in rats.

1996 • 47 citations

Substance P and inflammatory pain: potential of substance P antagonists as analgesics.

1993 • 44 citations

Two types of acetylcholine receptors on the soma of primary afferent neurons

1984 • 29 citations

Tolerance to the antinociceptive effect of epibatidine after acute and chronic administration in mice

1996 • 24 citations

Contribution of adrenal hormones to nicotine‐induced inhibition of synovial plasma extravasation in the rat

1997 • 12 citations

Modifications of the opioid system reactivity in Freund's adjuvant induced-arthritic and carrageenin-injected rats, models or chronic and acute inflammatory pain: behavioural and electrophysiological studies

1988 • 3 citations

A comparison of (±)epibatidine with NMDA in releasing [3H]noradrenaline and adenosine from slices of rat hippocampus and parietal cortex

1997 • 2 citations

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