The Role of P2Y1 Purinergic Receptors and Cytosolic Ca2+ in Hypotonically Activated Osmolyte Efflux from a Rat Hepatoma Cell Line

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Receptors for Purines and Pyrimidines

2012 • 4,065 citations

Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase.

1990 • 3,250 citations

Extracellular metabolism of ATP and other nucleotides

2000 • 973 citations

Calcium-activated potassium channels

1998 • 934 citations

Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines.

1994 • 763 citations

The role of cellular hydration in the regulation of cell function

1996 • 571 citations

Cellular and Molecular Physiology of Cell Volume Regulation

2020 • 499 citations

Molecular pharmacology of P2Y-receptors

2000 • 490 citations

The pharmacology of mechanogated membrane ion channels.

1996 • 422 citations

Properties of volume-regulated anion channels in mammalian cells

1997 • 357 citations

Identification of a Novel Human ADP Receptor Coupled to Gi

2001 • 333 citations

Autocrine signaling through ATP release represents a novel mechanism for cell volume regulation.

1996 • 328 citations

The Diversity of Volume Regulatory Mechanisms

1998 • 310 citations

Practical Aspects of Measuring [Ca2+] with Fluorescent Indicators

1994 • 294 citations

Studies on apyrases

1961 • 256 citations

Identification of competitive antagonists of the P2Y1 receptor.

1996 • 245 citations

Bioluminescence detection of ATP release mechanisms in epithelia

1998 • 242 citations

A release mechanism for stored ATP in ocular ciliary epithelial cells

1998 • 233 citations

Isolated rat hepatocytes can signal to other hepatocytes and bile duct cells by release of nucleotides.

1996 • 225 citations

Hepatocellular ATP-binding Cassette Protein Expression Enhances ATP Release and Autocrine Regulation of Cell Volume

1997 • 165 citations

Effects of channel modulators on cloned large-conductance calcium-activated potassium channels.

1996 • 163 citations

Studies On The Development, Biochemistry, And Biology Of Experimental Hepatomas

1965 • 157 citations

Swelling-activated Organic Osmolyte Channels

1997 • 155 citations

Extracellular ATP signaling and P2X nucleotide receptors in monolayers of primary human vascular endothelial cells

2002 • 144 citations

Mechanical strain-induced Ca²⁺waves are propagated via ATP release and purinergic receptor activation

2000 • 143 citations

Swelling-Induced, Cftr-Independent Atp Release from a Human Epithelial Cell Line

1999 • 130 citations

Brefeldin A Block of Integrin-dependent Mechanosensitive ATP Release from Xenopus Oocytes Reveals a Novel Mechanism of Mechanotransduction

2001 • 116 citations

TNF-α and insulin, alone and synergistically, induce plasminogen activator inhibitor-1 expression in adipocytes

1999 • 109 citations

Preparation of solutions with free calcium concentration in the nanomolar range using 1,2-bis(o-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid

1991 • 103 citations

Volume-sensitive purinergic signaling in human hepatocytes

2000 • 103 citations

Adenosine Nucleotides Acting at the Human P2Y1Receptor Stimulate Mitogen-activated Protein Kinases and Induce Apoptosis

2001 • 98 citations

Cell swelling-induced ATP release and gadolinium-sensitive channels

2002 • 97 citations

Influence of Calcium on Regulatory Volume Decrease: Role of Potassium Channels

2000 • 92 citations

Molecular cloning and functional characterization of a rat pituitary G protein-coupled adenosine triphosphate (ATP) receptor.

1996 • 92 citations

Identification of the P2Y(12) receptor: a novel member of the P2Y family of receptors activated by extracellular nucleotides.

2001 • 90 citations

Swelling‐activated, cystic fibrosis transmembrane conductance regulator‐augmented ATP release and Cl⁻ conductances in murine C127 cells

2000 • 88 citations

Properties of two apyrases from Solanum tuberosum

1982 • 67 citations

Receptor-Mediated Facilitation of Cell Volume Regulation by Swelling-Induced ATP Release in Human Epithelial Cells.

2000 • 64 citations

Volume-dependent taurine release from cultured astrocytes requires permissive [Ca²⁺]_iand calmodulin

1999 • 63 citations

Identification and Characterization of a Novel Hepatic Canalicular ATP Diphosphohydrolase

2000 • 59 citations

Osmotic cell swelling-induced ATP release mediates the activationof extracellular signal-regulated protein kinase (Erk)-1/2 but not the activation of osmo-sensitive anion channels

1999 • 58 citations

Characterization of volume-sensitive taurine- and Cl(-)-permeable channels

1997 • 50 citations

Organic Osmolyte Channels: A Comparative View

2000 • 49 citations

A chimeric rat brain P2Y1 receptor tagged with green-fluorescent protein: High-affinity ligand recognition of adenosine diphosphates and triphosphates and selectivity identical to that of the wild-type receptor

2000 • 42 citations

Evidence that rat hepatocytes co‐express functional P2Y₁ and P2Y₂ receptors

2000 • 38 citations

Inhibitory effects of some purinergic agents on ecto-ATPase activity and pattern of stepwise ATP hydrolysis in rat liver plasma membranes

2000 • 36 citations

Participation Of Atp In Cell Volume Regulation In The Endothelium After Hypotonic Stress

2001 • 35 citations

Purinergic-independent Calcium Signaling Mediates Recovery from Hepatocellular Swelling

2001 • 34 citations

Osmoregulation of Liver Cell Function: Signalling, Osmolytes and Cell Heterogeneity

1998 • 33 citations

Characterization of a swelling-activated anion conductance in homozygous typing cell hepatoma cells

1997 • 32 citations

Pharmacology of volume regulation following hypotonicity-induced cell swelling in clonal N1E115 neuroblastoma cells

1995 • 24 citations

Osmotic cell swelling-induced ATP release mediates the activationof extracellular signal-regulated protein kinase (Erk)-1/2 but not the activation of osmo-sensitive anion channels

1999 • 19 citations

Evidence that 2‐methylthioATP and 2‐methylthioADP are both agonists at the rat hepatocyte P2Y₁ receptor

2000 • 18 citations