The Hepatocyte Nuclear Factor 3 (HNF3 or FOXA) Family in Metabolism

Insulin-promoter-factor 1 is required for pancreas development in mice

1994 • 1,789 citations

PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum

1996 • 1,505 citations

Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone H5

1993 • 1,269 citations

Unified nomenclature for the winged helix/forkhead transcription factors

2000 • 1,136 citations

Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence

1997 • 1,107 citations

HNF-3β is essential for node and notochord formation in mouse development

1994 • 985 citations

The winged-helix transcription factor HNF-3β is required for notochord development in the mouse embryo

1994 • 786 citations

The homeotic gene fork head encodes a nuclear protein and is expressed in the terminal regions of the Drosophila embryo

1989 • 760 citations

Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo

1993 • 680 citations

The formation and maintenance of the definitive endoderm lineage in the mouse: involvement of HNF3/forkhead proteins

1993 • 619 citations

Multiple hepatocyte-enriched nuclear factors function in the regulation of transthyretin and alpha 1-antitrypsin genes.

1989 • 545 citations

Hepatocyte nuclear factor 3 alpha belongs to a gene family in mammals that is homologous to the Drosophila homeotic gene fork head.

1991 • 517 citations

Liver‐enriched transcription factors and hepatocyte differentiation

1996 • 508 citations

Postimplantation expression patterns indicate a role for the mouse forkhead/HNF-3 α, β and γ genes in determination of the definitive endoderm, chordamesoderm and neuroectoderm

1993 • 505 citations

HNF-3A, a hepatocyte-enriched transcription factor of novel structure is regulated transcriptionally.

1990 • 466 citations

Binding of the winged-helix transcription factor HNF3 to a linker histone site on the nucleosome

1998 • 373 citations

Regulation of a Transcription Factor Network Required for Differentiation and Metabolism

1998 • 343 citations

Hepatocyte Nuclear Factor 3β is Involved in Pancreatic β-Cell-Specific Transcription of the pdx-1 Gene

1997 • 256 citations

Inactivation of the winged helix transcription factor HNF3alpha affects glucose homeostasis and islet glucagon gene expression in vivo

1999 • 241 citations

Position and orientation of the globular domain of linker histone H5 on the nucleosome

1998 • 232 citations

Hepatic Nuclear Factor 3- and Hormone-Regulated Expression of the Phosphoenolpyruvate Carboxykinase and Insulin-Like Growth Factor-Binding Protein 1 Genes

1995 • 226 citations

Somatic linker histones cause loss of mesodermal competence in Xenopus

1997 • 191 citations

Sequential expression of HNF-3β and HNF-3α by embryonic organizing centers: the dorsal lip/node, notochord and floor plate

1993 • 189 citations

Hepatocyte nuclear factor 3 beta contains two transcriptional activation domains, one of which is novel and conserved with the Drosophila fork head protein.

1992 • 188 citations

Activation of the tyrosine aminotransferase gene is dependent on synergy between liver-specific and hormone-responsive elements.

1993 • 187 citations

HORMONE RESPONSE DOMAINS IN GENE TRANSCRIPTION

1992 • 185 citations

Pancreatic β Cell-specific Transcription of thepdx-1 Gene

2000 • 161 citations

Prolonged glucocorticoid exposure dephosphorylates histone H1 and inactivates the MMTV promoter

1998 • 144 citations

Impaired glucose homeostasis and neonatal mortality in hepatocyte nuclear factor 3α-deficient mice

1999 • 141 citations

Targeted Disruption of the Gene Encoding Hepatocyte Nuclear Factor 3γ Results in Reduced Transcription of Hepatocyte-Specific Genes

1998 • 137 citations

Hepatocyte Nuclear Factor 3β (Foxa2) Is Dispensable for Maintaining the Differentiated State of the Adult Hepatocyte

2000 • 135 citations

Analysis of hepatocyte nuclear factor-3β protein domains required for transcriptional activation and nuclear targeting

1995 • 127 citations

Hormonal Regulation of an Islet-Specific Enhancer in the Pancreatic Homeobox Gene STF-1

1997 • 114 citations

Glucocorticoids and insulin regulate expression of the human gene for insulin-like growth factor-binding protein-1 through proximal promoter elements.

1994 • 94 citations

Glucagon Deficiency Causing Severe Neonatal Hypoglycemia in a Patient with Normal Insulin Secretion

1977 • 76 citations

Glucagon gene expression is negatively regulated by hepatocyte nuclear factor 3 beta.

1994 • 71 citations

Binding Sites for Hepatocyte Nuclear Factor 3β or 3γ and Pancreas Transcription Factor 1 Are Required for Efficient Expression of the Gene Encoding Pancreatic α-Amylase

1995 • 58 citations

Metabolic control of gene expression: in vivo studies with transgenic mice

1992 • 44 citations

Antiglucocorticoid activity of hepatocyte nuclear factor-6

1999 • 39 citations

Glucocorticoids are insufficient for neonatal gene induction in the liver

1998 • 29 citations

Cloning of cDNA and the gene encoding human hepatocyte nuclear factor (HNF)-3β and mutation screening in Japanese subjects with maturity-onset diabetes of the young

2000 • 22 citations

Assignment of the Human Genes for Hepatocyte Nuclear Factor 3-α, -β, and -γ (HNF3A, HNF3B, HNF3G) to 14q12–q13, 20p11, and 19q13.2–q13.4

1997 • 14 citations