Treatment with HIF-1α Antagonist PX-478 Inhibits Progression and Spread of Orthotopic Human Small Cell Lung Cancer and Lung Adenocarcinoma in Mice

Cancer Statistics, 2008

2008 • 10,165 citations

Targeting HIF-1 for cancer therapy

2003 • 6,321 citations

Paclitaxel–Carboplatin Alone or with Bevacizumab for Non–Small-Cell Lung Cancer

2006 • 5,595 citations

Erlotinib in Previously Treated Non–Small-Cell Lung Cancer

2005 • 5,383 citations

Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer)

2005 • 2,102 citations

TRIBUTE: A Phase III Trial of Erlotinib Hydrochloride (OSI-774) Combined With Carboplatin and Paclitaxel Chemotherapy in Advanced Non–Small-Cell Lung Cancer

2005 • 1,517 citations

General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia.

1993 • 1,441 citations

Relation of hypoxia inducible factor 1α and 2α in operable non-small cell lung cancer to angiogenic/molecular profile of tumours and survival

2001 • 467 citations

Evaluation of HIF-1 inhibitors as anticancer agents

2007 • 358 citations

HIF-1 regulation: not so easy come, easy go

2008 • 315 citations

Antitumor activity and pharmacodynamic properties of PX-478, an inhibitor of hypoxia-inducible factor-1alpha.

2004 • 272 citations

Three-Gene Prognostic Classifier for Early-Stage Non–Small-Cell Lung Cancer

2007 • 258 citations

Antitumor activity and pharmacodynamic properties of PX-478, an inhibitor of hypoxia-inducible factor-1α

2004 • 204 citations

Prognostic significance of hypoxia-inducible factor-1 , TWIST1 and Snail expression in resectable non-small cell lung cancer

2009 • 200 citations

Development of an orthotopic model to study the biology and therapy of primary human lung cancer in nude mice.

2003 • 158 citations

PX‐478, an inhibitor of hypoxia‐inducible factor‐1α, enhances radiosensitivity of prostate carcinoma cells

2008 • 103 citations

Targeted therapy of orthotopic human lung cancer by combined vascular endothelial growth factor and epidermal growth factor receptor signaling blockade

2007 • 88 citations

DEC1 (STRA13) protein expression relates to hypoxia‐ inducible factor 1‐alpha and carbonic anhydrase‐9 overexpression in non‐small cell lung cancer

2003 • 87 citations

Hypoxia Inducible Factor-1alpha and Vascular Endothelial Growth Factor in Biopsies of Small Cell Lung Carcinoma

2009 • 53 citations

Expression of hypoxia-inducible factor-1 alpha and its prognostic significance in small-sized adenocarcinomas of the lung

2006 • 43 citations

Model of malignant pleural effusion of human lung adenocarcinoma in SCID mice.

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HIF Gene Expression in Cancer Therapy

2007 • 25 citations