In-vivo proton MR-spectroscopy of the human brain: Assessment of N-acetylaspartate (NAA) reduction as a marker for neurodegeneration

Clinical diagnosis of Alzheimer's disease

1984 • 27,279 citations

El escorial World Federation of Neurology criteria for the diagnosis of amyotrophic lateral sclerosis

1994 • 2,090 citations

Spatial Localization in NMR Spectroscopy in Vivo

1987 • 1,342 citations

Immunocytochemical localization of N-acetyl-aspartate with monoclonal antibodies

1991 • 625 citations

Evidence of Axonal Damage in the Early Stages of Multiple Sclerosis and Its Relevance to Disability

2001 • 507 citations

Specific Expression of N‐Acetylaspartate in Neurons, Oligodendrocyte‐Type‐2 Astrocyte Progenitors, and Immature Oligodendrocytes In Vitro

1992 • 504 citations

Absolute Quantitation of Water and Metabolites in the Human Brain. II. Metabolite Concentrations

1993 • 499 citations

Alzheimer disease: depiction of increased cerebral myo-inositol with proton MR spectroscopy.

1993 • 354 citations

In vivo quantification of brain metabolites by 1H-MRS using water as an internal standard

1993 • 281 citations

¹ H NMR spectroscopy studies of Huntington's disease

1998 • 235 citations

Abnormal cerebral metabolite concentrations in patients with probable alzheimer disease

1994 • 217 citations

Changes of hippocampal N-acetyl aspartate and volume in Alzheimer's disease

1997 • 198 citations

Frontotemporal dementia and early Alzheimer disease: differentiation with frontal lobe H-1 MR spectroscopy.

1997 • 187 citations

Proton MR spectroscopy detects a relative decrease of N-acetylaspartate in the medial temporal lobe of patients with AD

2000 • 178 citations

Axonal injury and membrane alterations in Alzheimer's disease suggested by in vivo proton magnetic resonance spectroscopic imaging

1994 • 161 citations

Proton magnetic resonance spectroscopic imaging in progressive supranuclear palsy, Parkinson's disease and corticobasal degeneration

1997 • 142 citations

A 1H MRS study of probable Alzheimer’s disease and normal aging: implications for longitudinal monitoring of dementia progression

1999 • 141 citations

In Vivo Brain Concentrations of N-Acetyl Compounds, Creatine, and Choline in Alzheimer Disease

1999 • 136 citations

Proton magnetic resonance spectroscopy can differentiate Alzheimer's disease from normal aging

1997 • 133 citations

Proton Magnetic Resonance Spectroscopy of the Primary Motor Cortex in Patients With Motor Neuron Disease

1998 • 123 citations

Studies of Acute Ischemic Stroke With Proton Magnetic Resonance Spectroscopy

1998 • 100 citations

Regional Gray and White Matter Metabolite Differences in Subjects With AD, With Subcortical Ischemic Vascular Dementia, and Elderly Controls With 1H Magnetic Resonance Spectroscopic Imaging

1996 • 96 citations

Alzheimer disease: quantitative H-1 MR spectroscopic imaging of frontoparietal brain.

1998 • 86 citations

Subcortical Ischemic Vascular Dementia: Assessment with Quantitative MR Imaging and 1H MR Spectroscopy

2000 • 66 citations

Metabolic brain mapping in Alzheimer's disease using proton magnetic resonance spectroscopy

1998 • 55 citations

PROTON MAGNETIC RESONANCE SPECTROSCOPY IN DEMENTIA OF ALZHEIMER TYPE

1997 • 44 citations

Nuclear magnetic resonance spectroscopy: A review of neuropsychiatric applications

1995 • 44 citations

MR spectroscopy in amyotrophic lateral sclerosis/motor neuron disease

1997 • 35 citations

Proton MR spectroscopy and neuropsychological testing in adrenoleukodystrophy.

1997 • 33 citations

Incorporation of Lactate Measurement in Multi‐Spin‐Echo Proton Spectroscopic Imaging

1995 • 27 citations

Proton Magnetic Resonance Spectroscopy in Kennedy Syndrome

1999 • 26 citations

Double inversion recovery improves water suppression in vivo

1993 • 18 citations

¹H-MR-spektroskopische Bildgebung bei Patienten mit klinisch gesichertem Morbus Alzheimer

1995 • 15 citations