Heart receptors for VIP, PHI and secretin are able to activate adenylate cyclase and to mediate inotropic and chronotropic effects. Species variations and physiopathology

Thyroid hormone regulation of beta-adrenergic receptor number.

1977 • 591 citations

Isolation and characterization of the intestinal peptide porcine PHI (PHI-27), a new member of the glucagon--secretin family.

1981 • 425 citations

Vasoactive intestinal peptide

1982 • 417 citations

Adenosine 3′:5′-Monophosphate-dependent Protein Kinase-catalyzed Phosphorylation Reaction and Its Relationship to Calcium Transport in Cardiac Sarcoplasmic Reticulum

1974 • 382 citations

Altered myocardial mechanics in diabetic rats.

1980 • 367 citations

Diabetes Mellitus Induces Changes in Cardiac Myosin of the Rat

1980 • 290 citations

Defective sarcoplasmic reticular calcium transport in diabetic cardiomyopathy

1983 • 289 citations

Altered Myocardial Function and Metabolism in Chronic Diabetes Mellitus without Ischemia in Dogs

1974 • 282 citations

Changes in central catecholaminergic neurons in the spontaneously (genetic) hypertensive rat.

1978 • 243 citations

The effect of streptozotocin-induced diabetes in rats on cardiac contractile proteins.

1981 • 196 citations

Reduced number of β-adrenergic receptors in the myocardium of spontaneously hypertensive rats

1978 • 193 citations

Diabetic autonomic neuropathy

1980 • 167 citations

Cyclic nucleotides and cardiac function.

1979 • 166 citations

Hormonally specific expression of cardiac protein kinase activity

1979 • 138 citations

Porcine peptide having N‐terminal histidine and C‐terminal isoleucine amide (PHI)

1980 • 134 citations

Changes in central catecholaminergic neurons in the spontaneously (genetic) hypertensive rat.

1978 • 121 citations

Peptidergic innervation of the mammalian sinus nodes: Vasoactive intestinal polypeptide, neurotensin, substance P

1981 • 121 citations

The effect of streptozotocin-induced diabetes in rats on cardiac contractile proteins.

1981 • 121 citations

Activation of myocardial adenyl cyclase by histamine in guinea pig, cat, and human heart

1971 • 104 citations

Development of left ventricular hypertrophy in young spontaneously hypertensive rats after peripheral sympathectomy.

1977 • 95 citations

Rat cardiac muscarinic receptors. I. Effects of guanine nucleotides on high- and low-affinity binding sites.

1982 • 90 citations

Presence of vasoactive intestinal peptide receptors coupled to adenylate cyclase in rat lung membranes

1981 • 84 citations

Effect of Glucagon on Cyclic 3',5'-AMP, Phosphorylase Activity and Contractility of Heart Muscle of the Rat

1970 • 84 citations

Cardiac performance of isolated perfused hearts from alloxan diabetic rats

1979 • 82 citations

The epinephrine‐induced activation of the cardiac slow Ca²⁺ channel is mediated by the cAMP‐dependent phosphorylation of calciductin, a 23 000 M_r sarcolemmal protein

1981 • 78 citations

Increased number of β-adrenergic receptors in the hypertrophied myocardium

1979 • 73 citations

The human heart beta-adrenergic receptors. I. Heterogeneity of the binding sites: presence of 50% beta 1- and 50% beta 2-adrenergic receptors.

1983 • 66 citations

Hormonal effects on glycogen metabolism in the rat heart in situ.

1966 • 65 citations

Cardiovascular effects of secretin

1970 • 64 citations

The human heart beta-adrenergic receptors. II. Coupling of beta 2-adrenergic receptors with the adenylate cyclase system.

1983 • 62 citations

Effects of PHI on vasoactive intestinal peptide receptors and adenylate cyclase activity in lung membranes. A comparison in man, rat, mouse and guinea pig

1982 • 60 citations

The site of phosphorylation of troponin I in the perfused rabbit heart. The effect of adrenaline

1980 • 57 citations

Secretin and VIP-stimulated adenylate cyclase from rat heart

1980 • 56 citations

Differences of cardiac reactivity between spontaneously hypertensive and normotensive rats

1972 • 56 citations

Phosphorylation and dephosphorylation of phosphorylase kinase in the perfused rat heart.

1979 • 51 citations

Characterization of Secretin and Vasoactive Intestinal Peptide Receptors in Rat Pancreatic Plasma Membranes Using the Native Peptides, Secretin-(7–27) and Five Secretin Analogues

1982 • 48 citations

Sympathetic nerve function and vascular reactivity in spontaneously hypertensive rats

1981 • 47 citations

Cardiac function and myosin ATPase in diabetic rats treated with insulin, T3, and T4

1983 • 47 citations

Relationship between impaired parasympathetic and sympathetic cardiovascular control in diabetes mellitus

1983 • 46 citations

Early decrease in secretin-, glucagon-, and isoproterenol-stimulated cardiac adenylate cyclase activity in rats treated with isoproterenol

1982 • 43 citations

Vasoactive Intestinal Peptide (VIP) and peptide having N-terminal histidine and C-terminal isoleucine amide (PHI) stimulate adenylate cyclase activity in human heart membranes

1982 • 42 citations

Characterization of glucagon-induced changes in rate, contractility and cyclic AMP levels in isolated cardiac preparations of the rat and guinea pig.

1981 • 42 citations

The in vitro chronotropic and inotropic effects of vasoactive intestinal peptide (VIP) on the atria and ventricular papillary muscle from Cynomolgus monkey heart

1984 • 36 citations

Topographical distribution of the secretin- and VIP-stimulated adenylate cyclase system in the heart of five animal species

1983 • 36 citations

Activation and stabilization of cardiac adenylate cyclase by GTP analog and fluoride

1978 • 35 citations

Axonal transport of protein in motor fibres of experimentally diabetic rats — Fast anterograde transport

1982 • 34 citations

Secretin and VIP-stimulated adenylate cyclase from rat heart

1980 • 30 citations

Phosphorylation and activation of the cardiac isoenzyme of phosphorylase kinase by the cAMP-dependent protein kinase.

1981 • 27 citations

Effects of Experimental Diabetes and Genetic Obesity on Regional Blood Flow in the Rat

1977 • 26 citations

Comparison of VIP-secretin receptors in rat and human lung

1981 • 26 citations

Characterization of the VIP- and secretin-stimulated adenylate cyclase system from human lung

1981 • 26 citations

Heterogeneity of VIP-recognizing binding sites in rat tissues

1982 • 25 citations

Impairment of Hormone-Stimulated cardiac adenylate cyclase activity in the genetically obese (fa/fa) Zucker rat

1981 • 24 citations

Chronic effects of 6-hydroxydopamine and reserpine on myocardial adenylate cyclase

1978 • 18 citations

Relaxing effects of catecholamines in the heart

1980 • 16 citations

Effects of experimental diabetes and genetic obesity on regional blood flow in the rat

1977 • 15 citations

EFFECT OF SECRETIN ON PACEMAKER ACTIVITY AND CONTRACTILITY IN THE ISOLATED BLOOD-PERFUSED ATRIUM OF THE DOG

1976 • 15 citations

Glucagon-induced desensitization: Correlation between cyclic AMP levels and contractile force

1982 • 15 citations

Secretin-induced changes in rate, contractility and adenylate cyclase activity in rat heart atria

1984 • 14 citations

SECRETIN: HIGH PLASMA LEVELS IN DIABETES MELLITUS

1977 • 13 citations

The cardiac inotropic response to secretin is lower in genetically obese (fa/fa) than in lean (fa/?) Zucker rats

1983 • 13 citations

Specific decrease of secretin/VIP-stimulated adenylate cyclase in the heart from the Lyon strain of hypertensive rats

1984 • 10 citations

Effect of VIP on the exocrine pancreas

1982 • 10 citations

Decreased secretin and glucagon responsiveness of adenylate cyclase in cardiac membranes from hypothyroid rats

1981 • 9 citations

Selective Alteration of Secretin-Stimulated Cardiac Adenylate Cyclase Activity in Streptozotocin-Diabetic Rats

1983 • 8 citations

The adenylate cyclase activity in heart membranes from normotensive and spontaneously hypertensive rats, after chemical sympathectomy, suggests the presence of presynaptic secretin receptors

1983 • 6 citations