The copper-iron chronicles: the story of an intimate relationship.

The acute phase response

1994 • 2,927 citations

Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter

2000 • 1,624 citations

A Novel Duodenal Iron-Regulated Transporter, IREG1, Implicated in the Basolateral Transfer of Iron to the Circulation

2000 • 1,413 citations

A Novel Mammalian Iron-regulated Protein Involved in Intracellular Iron Metabolism

2000 • 1,259 citations

Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse

1999 • 1,068 citations

An Iron-Regulated Ferric Reductase Associated with the Absorption of Dietary Iron

2001 • 1,038 citations

ON BIMOLECULAR LAYERS OF LIPOIDS ON THE CHROMOCYTES OF THE BLOOD

1925 • 804 citations

The Possible Significance of the Ferrous Oxidase Activity of Ceruloplasmin in Normal Human Serum

1966 • 672 citations

A Permease-Oxidase Complex Involved in High-Affinity Iron Uptake in Yeast

1996 • 666 citations

Molecular characterization of a copper transport protein in S. cerevisiae: An unexpected role for copper in iron transport

1994 • 660 citations

The FET3 gene of S. cerevisiae encodes a multicopper oxidase required for ferrous iron uptake

1994 • 659 citations

Targeted gene disruption reveals an essential role for ceruloplasmin in cellular iron efflux

1999 • 572 citations

Transferrin receptor is necessary for development of erythrocytes and the nervous system

1999 • 555 citations

Autosomal-dominant hemochrom-atosis is associated with a mutation in the ferroportin (SLC11A3) gene

2001 • 499 citations

A mutation in SLC11A3 is associated with autosomal dominant hemochromatosis

2001 • 494 citations

Investigations in Serum Copper. II. Isolation of the Copper Containing Protein, and a Description of some of its Properties.

1948 • 465 citations

Deficiency of Ceruloplasmin in Patients with Hepatolenticular Degeneration (Wilson's Disease)

1952 • 441 citations

Mechanisms in Bioenergetics

1965 • 422 citations

Hypocupremia Induced by Zinc Therapy in Adults

1978 • 369 citations

IRON IN NUTRITION VII. COPPER AS A SUPPLEMENT TO IRON FOR HEMOGLOBIN BUILDING IN THE RAT

2009 • 362 citations

The role of ceruloplasmin in iron metabolism

1970 • 360 citations

An Iron-binding Component in Human Blood Plasma

1946 • 349 citations

A Novel Glycosylphosphatidylinositol-anchored Form of Ceruloplasmin Is Expressed by Mammalian Astrocytes

1997 • 318 citations

Studies on Copper Metabolism

1952 • 299 citations

Copper deficiency in long-term parenteral nutrition

1972 • 292 citations

Familial apoceruloplasmin deficiency associated with blepharospasm and retinal degeneration

1987 • 289 citations

Role of Hypoxia-inducible Factor-1 in Transcriptional Activation of Ceruloplasmin by Iron Deficiency

2000 • 275 citations

Tissue distribution and clearance kinetics of non-transferrin-bound iron in the hypotransferrinemic mouse: a rodent model for hemochromatosis.

1987 • 266 citations

Iron metabolism in copper-deficient swine

1968 • 258 citations

Aceruloplasminemia: an inherited neurodegenerative disease with impairment of iron homeostasis

1998 • 249 citations

Hereditary ceruloplasmin deficiency with hemosiderosis: A clinicopathological study of a japanese family

1995 • 242 citations

The Mobilization of Iron from the Perfused Mammalian Liver by a Serum Copper Enzyme, Ferroxidase I

1971 • 237 citations

Raw Hen Egg White and the Role of Iron In Growth Inhibition of Shigella dysenteriae , Staphylococcus aureus , Escherichia coli and Saccharomyces cerevisiae

1944 • 237 citations

Old iron, young copper: from Mars to Venus.

2001 • 237 citations

STUDIES ON COPPER METABOLISM. XIV. COPPER, CERULO-PLASMIN AND OXIDASE ACTIVITY IN SERA OF NORMAL HUMAN SUBJECTS, PREGNANT WOMEN, AND PATIENTS WITH INFECTION, HEPATOLENTICULAR DEGENERATION AND THE NEPHROTIC SYNDROME 1

1955 • 236 citations

Anemia and Neutropenia Caused by Copper Deficiency

1974 • 234 citations

COPPER DEFICIENCY IN INFANCY

1964 • 227 citations

Iron and copper transport in yeast and its relevance to human disease

1998 • 224 citations

Genes that modify the hemochromatosis phenotype in mice

2000 • 219 citations

Haemocuprein and hepatocuprein, copper-protein compounds of blood and liver in mammals

1938 • 216 citations

Historic uses of copper compounds in medicine

1985 • 215 citations

Investigations in Serum Copper. I. Nature of Serum Copper and its Relation to the Iron-Binding Protein in Human Serum.

1947 • 207 citations

Single-chain structure of human ceruloplasmin: the complete amino acid sequence of the whole molecule.

1984 • 206 citations

Automated measurement of serum ferroxidase activity

1998 • 197 citations

Role of Ceruloplasmin in Cellular Iron Uptake

1998 • 196 citations

Mobilization of Liver Iron by Ferroxidase (Ceruloplasmin)

1969 • 158 citations

THE ANEMIA OF INFECTION. I. HYPOFERREMIA, HYPERCUPREMIA, AND ALTERATIONS IN PORPHYRIN METABOLISM IN PATIENTS 1

1946 • 150 citations

An Oxidase-Permease-based Iron Transport System in Schizosaccharomyces pombe and Its Expression in Saccharomyces cerevisiae

1997 • 145 citations

Effect of ceruloplasmin on plasma iron in copper-deficient swine

1969 • 145 citations

Some biochemical and physiological aspects of copper in animal nutrition

1931 • 144 citations

Ceruloplasmin Ferroxidase Activity Stimulates Cellular Iron Uptake by a Trivalent Cation-specific Transport Mechanism

1999 • 143 citations

Cloning and gastrointestinal expression of rat hephaestin: relationship to other iron transport proteins

2001 • 138 citations

Studies on Copper Metabolisn

1952 • 138 citations

Relative Roles of Albumin and Ceruloplasmin in the Formation of Homocystine, Homocysteine-Cysteine-mixed Disulfide, and Cystine in Circulation

2001 • 131 citations

THE BIOLOGICAL SIGNIFICANCE OF COPPER AND ITS RELATION TO IRON METABOLISM

1935 • 131 citations

Complete cDNA sequence of human preceruloplasmin.

1986 • 129 citations

Iron Metabolism in Eukaryotes—Mars and Venus at It Again

1996 • 126 citations

STUDIES ON COPPER METABOLISM. VII. BLOOD COPPER IN PREGNANCY AND VARIOUS PATHOLOGIC STATES 1

1953 • 125 citations

An X-ray structural study of human ceruloplasmin in relation to ferroxidase activity

1997 • 124 citations

Preparation and Properties of Serum and Plasma Proteins. XXVIII. The β₁-Metal-combining Protein of Human Plasma^{1a, b}

1952 • 123 citations

Excessive zinc ingestion. A reversible cause of sideroblastic anemia and bone marrow depression

1990 • 120 citations

Enlargement of Mitochondrial Compartment in Iron and Copper Deficiency

1970 • 120 citations

Copper depletion and deficiency in the malnourished infant.

1969 • 120 citations

Oxidase reactions in human plasma caused by coeruloplasmin

1951 • 118 citations

Hereditary caeruloplasmin deficiency, dementia and diabetes mellitus.

1994 • 116 citations

STUDIES ON FREE ERYTHROCYTE PROTOPORPHYRIN, PLASMA IRON AND PLASMA COPPER IN NORMAL AND ANEMIC SUBJECTS

1948 • 113 citations

A Micromethod for the Determination of Ferroxidase (Ceruloplasmin) in Human Serums

1967 • 110 citations

THE RELATION OF IRON AND COPPER TO THE CYTOCHROME AND OXIDASE CONTENT OF ANIMAL TISSUES

1934 • 107 citations

IRON IN NUTRITION

1929 • 98 citations

Zinc-Induced Copper Deficiency: Megamineral Sideroblastic Anemia

1985 • 98 citations

Role of copper in mitochondrial iron metabolism

1976 • 97 citations

STUDIES ON FREE ERYTHROCYTE PROTOPORPHYRIN, SERUM IRON, SERUM IRON-BINDING CAPACITY AND PLASMA COPPER DURING NORMAL PREGNANCY 1

1949 • 90 citations

THE RELATION OF IRON AND COPPER TO HEMOGLOBIN SYNTHESIS IN THE CHICK

1929 • 85 citations

A coupled iron-caeruloplasmin oxidation system

1960 • 79 citations

Chemical, physiological, and immunological properties and clinical uses of blood derivatives

1947 • 76 citations

Extracellular Ferrireductase Activity of K562 Cells is Coupled to Transferrin-Independent Iron Transport

1994 • 73 citations

Rethinking the role of ceruloplasmin in brain iron metabolism

2001 • 72 citations

THE ACTION OF COPPER IN IRON METABOLISM

1932 • 71 citations

IRON IN NUTRITION

1928 • 70 citations

Rapid Development of Severe Copper Deficiency in a Patient With Crohn's Disease Receiving Parenteral Nutrition

1999 • 70 citations

Adverse effects of high dietary iron and ascorbic acid on copper status in copper-deficient and copper-adequate rats

1988 • 64 citations

Factors influencing serum ceruloplasmin levels in normal individuals.

1966 • 63 citations

Some properties of coupled iron–caeruloplasmin oxidation systems

1961 • 62 citations

Does transferrin exhibit ferroxidase activity?

1973 • 62 citations

THE RÔLE OF COPPER IN HEMOGLOBIN REGENERATION AND IN REPRODUCTION

1931 • 60 citations

IRON IN NUTRITION

1925 • 60 citations

Hereditary Defect in Iron Absorption in Mice

1967 • 60 citations

Role of ceruloplasmin and ascorbate in cellular iron release

1999 • 59 citations

Ceruloplasmin, transferrin and apotransferrin facilitate iron release from human liver cells

1997 • 59 citations

STUDIES ON COPPER METABOLISM. XIX

1956 • 57 citations

Copper as a supplement to iron for hemoglobin building in the rat

1928 • 55 citations

Sex-Linked Anemia: A Hypochromic Anemia of Mice

1966 • 55 citations

The Iron-Copper Connection: The Link to Ceruloplasmin Grows Stronger

2009 • 54 citations

Development of Anemia in Copper-Deficient Rats Fed High Levels of Dietary Iron and Sucrose

1986 • 52 citations

Chlorosis, anaemia, and anorexia nervosa.

1980 • 51 citations

THE RELATION OF COPPER TO THE HEMOGLOBIN CONTENT OF RAT BLOOD

1928 • 50 citations

Studies on Copper Metabolism

1952 • 50 citations

Studies on Copper Metabolism

1956 • 49 citations

The genetics of sex-linked anaemia in the mouse

1962 • 49 citations

Erythropoietin response and route of administration.

1994 • 49 citations

THE RELATION OF COPPER TO CYTOCHROME OXIDASE AND HEMATOPOIETIC ACTIVITY OF THE BONE MARROW OF RATS

1941 • 49 citations

METALLIC ELEMENTS AND BLOOD FORMATION

1940 • 49 citations

A sex-linked anaemia in the mouse

1962 • 47 citations

Iron in nutrition: VII. Copper as a supplement to iron for hemoglobin building in the rat

2001 • 45 citations

Iron overload can induce mild copper deficiency

2001 • 45 citations

Copper deficiency in infants fed cow milk

1985 • 45 citations

Fever and acute phase response induced in rabbits by human recombinant interferon‐gamma.

1987 • 44 citations

X‐Linked Hypochromic Anaemia of Mice

1967 • 43 citations

Some Interrelationships of Dietary Iron, Copper and Cobalt in Metabolism

1946 • 41 citations

Heme Biosynthesis in Copper Deficient Swine

1968 • 39 citations

THE NECESSITY OF COPPER AS A SUPPLEMENT TO IRON FOR HEMOGLOBIN FORMATION IN THE PIG

1932 • 39 citations

THE INABILITY OF METALS OTHER THAN COPPER TO SUPPLEMENT IRON IN CURING THE NUTRITIONAL ANEMIA OF RATS

1931 • 38 citations

Histological evidence of disordered iron transport in the X‐linked hypochromic anaemia of mice

1968 • 38 citations

STUDIES ON IRON METABOLISM AND THE INFLUENCE OF COPPER

1932 • 37 citations

Elevated PBI, free thyroxine, and plasma protein concentration in man at high altitude.

1966 • 36 citations

On the Presence of n laccase-like Enzyme in Nerum and its Relation to the Copper in Serum.

1944 • 36 citations

THE BLOOD PICTURE OF IRON AND COPPER DEFICIENCY ANEMIAS IN THE RAT

1944 • 34 citations

Reduced serum ceruloplasmin levels in hereditary haemochromatosis

2001 • 33 citations

Role of Copper in Iron Localization in Developing Erythrocytes

1969 • 33 citations

The Regulation of Iron Release from the Perfused Rat Liver

1980 • 32 citations

Inflammation triggers hypoferremia and de novo synthesis of serum transferrin and ceruloplasmin in mice

1984 • 31 citations

Mapping the Gene for Sex-Linked Anemia: An Inherited Defect of Intestinal Iron Absorption in the Mouse

1998 • 31 citations

Active Transport of Iron by Intestine: Selective Genetic Defect in the Mouse

1970 • 30 citations

THE AVAILABILITY OF COPPER IN VARIOUS COMPOUNDS AS A SUPPLEMENT TO IRON IN HEMOGLOBIN FORMATION

1934 • 29 citations

The diseases called chlorosis

1984 • 29 citations

IRON AND COPPER IN THE TREATMENT OF ANEMIA IN CHILDREN

1931 • 27 citations

Ceruloplasmin promotes iron uptake rather than release in BT325 cells

2001 • 27 citations

Iron Supplementation Does Not Affect Cell Proliferation or Aberrant Crypt Foci Development in the Colon of Sprague-Dawley Rats , ,

1998 • 26 citations

Function of Copper in the Metabolism of Iron

1967 • 26 citations

Relation of ferroxidase (ceruloplasmin) to iron absorption.

1969 • 25 citations

IS COPPER A CONSTITUENT OF THE HEMOGLOBIN MOLECULE?

1929 • 24 citations

STUDIES IN THE NUTRITIONAL ANEMIA OF THE RAT

1934 • 24 citations

THE RELATION OF IRON AND COPPER TO THE RETICULOCYTE RESPONSE IN ANEMIC RATS

1933 • 23 citations

Studies on the roles of apotransferrin and caeruloplasmin (EC1.16.3.1) on iron absorption in copper-deficient rats using an isolated vascularly- and luminally-perfused intestinal preparation

1988 • 23 citations

Chlorosis – the ‘green sickness’

1981 • 23 citations

THE DIAGNOSIS AND TREATMENT OF THE IRON-DEFICIENCY ANEMIAS

1934 • 23 citations

The protective action of ceruloplasmin on Fe2+ stimulated lysis of rat erythrocytes

1981 • 22 citations

Serum ceruloplasmin and ferroxidase activity are decreased in HFE C282Y homozygote male iron-overloaded patients

2002 • 21 citations

The oxidation of cysteine by ceruloplasmin

1975 • 20 citations

The anemia of copper deficiency in dogs compared with that produced by iron deficiency.

1953 • 20 citations

The valency state of absorbed iron appearing in the portal blood and ceruloplasmin substitution

1990 • 20 citations

Uptake of circulating iron by the duodenum of normal mice and mice with altered iron stores, including sex-linked anemia: high resolution radioautographic study.

1976 • 19 citations

The Stimulating Action of Copper on Erythropoiesis

1933 • 18 citations

Über eine im intermediären Eisenstoffwechsel entstehende Ferriglobulinverbindung

1933 • 18 citations

The treatment of anæmia of infancy with iron and copper.

1931 • 18 citations

Effect of Metals Purified by Electrolytic Deposition on Hemoglobin Regeneration in Anaemic White Rat

1930 • 17 citations

Studies in the nutritional anæmia of the rat. 1. Influence of iron upon blood regeneration.

1931 • 16 citations

EFFECT OF IRON AND COPPER THERAPY ON HEMOGLOBIN CONTENT OF THE BLOOD OF INFANTS

1935 • 15 citations

Clinical Results on the Use of Human Ceruloplasmin in Aplastic Anemia

1979 • 15 citations

Studies in the nutritional anæmia of the rat. 2. Influence of iron plus supplements of other inorganic elements upon blood regeneration.

1931 • 15 citations

Action of Copper and Other Elements in Iron Metabolism

1933 • 14 citations

The kinetics of iron uptake by isolated intestinal cells from normal mice and mice with sex-linked anemia

1982 • 14 citations

Studies on the Nutritive Value of Milk

1929 • 14 citations

Effects of Oral Iron Therapy on Serum Copper and Serum Ceruloplasmin in Children

1994 • 13 citations

Copper as a supplement to iron for hemoglobin building in the rat (Hart et al., 1928).

1997 • 13 citations

THE TREATMENT OF IDIOPATHIC (HYPOCHROMIC) ANAEMIA WITH IRON AND COPPER.

1930 • 13 citations

Is ceruloplasmin a physiological ferroxidase?

1972 • 12 citations

THE INEFFECTIVENESS OF MANGANESE IN NUTRITIONAL ANEMIA

1931 • 11 citations

Copper metabolism in different states of erythropoiesis activity.

1978 • 10 citations

ANEMIA STUDIES WITH DOGS

1938 • 10 citations

SOME FACTORS REGULATING THE UTILIZATION OF SPLENIC IRON

1931 • 9 citations

Ueber den jetzigen Stand der Frage nach den pharmakologischen Wirkungen des Kupfers¹)

1895 • 8 citations

The effect of bleeding ulcers and hemorrhagic anemia upon whole blood copper and iron

1937 • 8 citations

COPPER AND ANEMIA

1933 • 8 citations

INFLUENCE OF COPPER AND A LIVER FRACTION ON RETENTION OF IRON

1937 • 8 citations

Serum ceruloplasmin in iron deficiency anaemia.

1975 • 8 citations

Hemolysis of rabbit erythrocytes in the presence of copper ions

1990 • 8 citations

Increased serum levels of ceruloplasmin in severe chronic airflow obstruction.

1987 • 6 citations

The role of copper in hemopoiesis.

1951 • 6 citations

Ferrous Iron Oxidation by Intestinal Mucosa: Possible Role in Mucosal Iron Metabolism

1973 • 6 citations

Serum copper and ceruloplasmin in pregnancy with anaemia.

1989 • 6 citations

THE ROLE OF COPPER IN IRON-DEFICIENCY ANAEMIA IN INFANCY

1938 • 6 citations

Rabbit Ceruloplasmin: Purification and Partial Characterization

1996 • 5 citations

The protective effect of different forms of human ceruloplasmin in copper-induced lysis of red blood cells.

1990 • 4 citations

Evidence for an iron carrier substance in copper-deficient mitochondria.

1978 • 4 citations

Die Bedingungen der Oxydation des Eisens im Blute

1933 • 4 citations

Ueber den jetzigen Stand der Frage nach den pharmakologischen Wirkungen des Kupfers (Schluss aus No. 1.)

1895 • 3 citations

Erythropoietic mechanism by combined use of ceruloplasmin and folic acid.

1969 • 2 citations

Ueber den Einfluss von Kupfer- und Zinksalzen auf die Hämoglobinbildung.

1899 • 2 citations

Studies in the biochemistry of copper. 5. Effect of rapid loss of blood upon the copper content of blood.

1934 • 2 citations

STUDIES ON THE HEMATOPOIETIC FACTOR CAERULOPLASMIN

1961 • 1 citations