The Geranylgeranyltransferase I Inhibitor GGTI-298 Induces Hypophosphorylation of Retinoblastoma and Partner Switching of Cyclin-dependent Kinase Inhibitors

Cancer Cell Cycles

1996 • 5,379 citations

ras GENES

1987 • 3,818 citations

Cell Cycle Checkpoints: Preventing an Identity Crisis

1996 • 2,056 citations

PROTEIN PRENYLATION: Molecular Mechanisms and Functional Consequences

1996 • 1,977 citations

Mitogenic Signaling Mediated by Oxidants in Ras-Transformed Fibroblasts

1997 • 1,582 citations

New functional activities for the p21 family of CDK inhibitors.

1997 • 1,414 citations

An Essential Role for Rho, Rac, and Cdc42 GTPases in Cell Cycle Progression Through G ₁

1995 • 1,142 citations

Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta.

1995 • 959 citations

Activation of Rac1, RhoA, and Mitogen-Activated Protein Kinases Is Required for Ras Transformation

1995 • 683 citations

A role for Rho in Ras transformation.

1995 • 538 citations

Ras CAAX Peptidomimetic FTI-277 Selectively Blocks Oncogenic Ras Signaling by Inducing Cytoplasmic Accumulation of Inactive Ras-Raf Complexes

1995 • 359 citations

Farnesol modification of Kirsten-ras exon 4B protein is essential for transformation.

1990 • 333 citations

Signal transduction from multiple Ras effectors

1997 • 308 citations

Differential Interaction of the Cyclin-dependent Kinase (Cdk) Inhibitor p27Kip1 with Cyclin A-Cdk2 and Cyclin D2-Cdk4

1997 • 284 citations

Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-Ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts

1998 • 229 citations

Ras CAAX peptidomimetic FTI 276 selectively blocks tumor growth in nude mice of a human lung carcinoma with K-Ras mutation and p53 deletion.

1995 • 226 citations

A new Rac target POSH is an SH3-containing scaffold protein involved in the JNK and NF-kappa B signalling pathways

1998 • 208 citations

The Geranylgeranyltransferase-I Inhibitor GGTI-298 Arrests Human Tumor Cells in G0/G1 and Induces p21WAF1/CIP1/SDI1 in a p53-independent Manner

1997 • 193 citations

Ras-stimulated Extracellular Signal-related Kinase 1 and RhoA Activities Coordinate Platelet-derived Growth Factor-induced G1 Progression through the Independent Regulation of Cyclin D1 and p27KIP1

1997 • 193 citations

Protein geranylgeranylation, not farnesylation, is required for the G1 to S phase transition in mouse fibroblasts.

1996 • 166 citations

GGTI-298 induces G0-G1 block and apoptosis whereas FTI-277 causes G2-M enrichment in A549 cells.

1997 • 139 citations

p21^WAF1/CIP1 Is Upregulated by the Geranylgeranyltransferase I Inhibitor GGTI-298 through a Transforming Growth Factor β- and Sp1-Responsive Element: Involvement of the Small GTPase RhoA

1998 • 138 citations

Inhibition of ras prenylation: A novel approach to cancer chemotherapy

1997 • 137 citations

Platelet-derived Growth Factor Receptor Tyrosine Phosphorylation Requires Protein Geranylgeranylation but not Farnesylation

1996 • 119 citations

Inhibition of Protein Geranylgeranylation Causes a Superinduction of Nitric-oxide Synthase-2 by Interleukin-1β in Vascular Smooth Muscle Cells

1997 • 71 citations

Cell Cycle Regulators in Cancer

1997 • 10 citations