Leukotrienes Mediate Delayed Airway Effects of 15‐HETE^a

IgE production by normal human lymphocytes is induced by interleukin 4 and suppressed by interferons gamma and alpha and prostaglandin E2.

1988 • 939 citations

Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis

1990 • 777 citations

Expression of mRNA for cyclooxygenase‐1 and cyclooxygenase‐2 in human tissues

1993 • 708 citations

Release of Prostaglandin D₂into Human Airways during Acute Antigen Challenge

1986 • 476 citations

Endogenous glucocorticoids regulate an inducible cyclooxygenase enzyme.

1992 • 471 citations

Inhibition of Exercise-Induced Bronchoconstriction by MK-571, a Potent Leukotriene D₄–Receptor Antagonist

1990 • 405 citations

Specific inflammatory cytokines regulate the expression of human monocyte 15-lipoxygenase.

1992 • 382 citations

Induction of human IgE synthesis requires interleukin 4 and T/B cell interactions involving the T cell receptor/CD3 complex and MHC class II antigens.

1989 • 331 citations

MK886, a potent and specific leukotriene biosynthesis inhibitor blocks and reverses the membrane association of 5-lipoxygenase in ionophore-challenged leukocytes.

1990 • 319 citations

Predominant generation of 15-lipoxygenase metabolites of arachidonic acid by epithelial cells from human trachea.

1985 • 289 citations

Slow-reacting substances (leukotrienes) contract human airway and pulmonary vascular smooth muscle in vitro

1981 • 285 citations

Pharmacology of L-660,711 (MK-571): a novel potent and selective leukotriene D₄ receptor antagonist

1989 • 266 citations

Arachidonic acid 15-lipoxygenase products from human eosinophils.

1982 • 193 citations

Identification of a pharmacologically distinct prostaglandin H synthase in cultured epithelial cells.

1992 • 191 citations

Identification of 15–hydroxy‐5,8,11,13–eicosatetraenoic acid (15–HETE) as a major metabolite of arachidonic acid in human lung

1980 • 112 citations

The actions of 5-, 12-, and 15-HETE on tracheobronchial smooth muscle

1982 • 59 citations

Actions of Lipoxin A4 and Related Compounds in Smooth Muscle Preparations and on the Microcirculation in Vivo

1988 • 55 citations

Cloning of human airway 15-lipoxygenase: identity to the reticulocyte enzyme and expression in epithelium

1992 • 46 citations

Stimulation of human airway epithelial cells by platelet activating factor (PAF) and arachidonic acid produces 15-hydroxyeicosatetraenoic acid (15-HETE) capable of contracting bronchial smooth muscle

1991 • 28 citations

The Airway Epithelium and Arachidonic Acid 15-Lipoxygenase

1991 • 15 citations

Reversed-phase ion-interaction chromatography of leukotrienes, lipoxins and related compounds

1988 • 13 citations