Histamine H2-receptor antagonists and gastric acid secretion

Definition and Antagonism of Histamine H2-receptors

1972 • 2,284 citations

RECEPTORS MEDIATING SOME ACTIONS OF HISTAMINE

1966 • 762 citations

Effect of Large Doses of Histamine on Gastric Secretion of HCl

1953 • 699 citations

PHARMACOLOGY OF A NEW ADRENERGIC BETA-RECEPTOR-BLOCKING COMPOUND (NETHALIDE)

1962 • 508 citations

Cimetidine—A Non-Thiourea H₂-Receptor Antagonist

1975 • 449 citations

Metiamide — An orally active histamine H2-receptor antagonist

1973 • 259 citations

H2-RECEPTOR ANTAGONISTS AND ANTACIDS IN THE PREVENTION OF ACUTE GASTROINTESTINAL HÆMORRHAGE IN FULMINANT HEPATIC FAILURE

1977 • 249 citations

The nature of the vaso‐dilator constituents of certain tissue extracts

1927 • 243 citations

Comparative Effects of Antacids, Cimetidine and Enteric Coating on the Therapeutic Response to Oral Enzymes in Severe Pancreatic Insufficiency

1977 • 231 citations

Ranitidine

1982 • 214 citations

Pharmacological evaluation of cimetidine, a new histamine H2‐receptor antagonist, in healthy man.

1975 • 198 citations

Effect of daily oral omeprazole on 24 hour intragastric acidity.

1983 • 187 citations

Report on the United States experience with cimetidine in Zollinger-Ellision syndrome and other hypersecretory states.

1978 • 184 citations

Inhibition of Gastric Acid Secretion by Cimetidine in Patients with Duodenal Ulcer

1975 • 181 citations

The action of histamine and 5-hydroxytryptamine on isolated mammalian atria.

1960 • 177 citations

Comparison of the effects of ranitidine, cimetidine and placebo on the 24 hour intragastric acidity and nocturnal acid secretion in patients with duodenal ulcer.

1981 • 167 citations

Prevention of acute gastrointestinal complications after severe head injury: A controlled trial of cimetidine prophylaxis

1980 • 165 citations

β-imidazolyläthylamin und die Organextrakte

1920 • 159 citations

Histamine and gastric secretion: a later look, 1955-1965.

1965 • 159 citations

International Symposium on Histamine H_2-Receptor Antagonists.

1974 • 155 citations

Report on the united states experience with cimetidine in zollinger-ellison syndrome and other hypersecretory states

1978 • 154 citations

Cimetidine Is an Antiandrogen in the Rat

1979 • 149 citations

CIMETIDINE IN DUODENAL ULCER Controlled Trial

1976 • 149 citations

Drug metabolism by rat and human hepatic microsomes in response to interaction with H2-receptor antagonists

1982 • 145 citations

Cimetidine-Induced Impotence and Breast Changes in Patients with Gastric Hypersecretory States

1983 • 144 citations

Au-antigen particles.

1970 • 139 citations

Intragastric nitrites, nitrosamines, and bacterial overgrowth during cimetidine treatment.

1982 • 138 citations

Prophylactic effect of cimetidine in duodenal ulcer disease.

1978 • 130 citations

Healing of Benign Gastric Ulcer with Low-Dose Antacid or Cimetidine

1983 • 118 citations

HISTAMINE AS A NORMAL STIMULANT OF GASTRIC SECRETION

1938 • 117 citations

CIMETIDINE AND GASTRIC CANCER

1979 • 115 citations

EFFECTS IN MAN OF HISTAMINE H2-RECEPTOR BLOCKADE BY BURIMAMIDE

1972 • 112 citations

On the Influence of the Pulse Amplitude on the Carotid Sinus Pressure Reflex

1942 • 109 citations

Comparison of Ranitidine and Cimetidine in the Treatment of Gastric Hypersecretion

1984 • 107 citations

Histamine and Gastric Secretion

1966 • 106 citations

Inhibition of food-stimulated gastric acid secretion by cimetidine.

1976 • 104 citations

Cimetidine treatment for the prevention of recurrence of duodenal ulcer: an international collaborative study

1980 • 95 citations

Improved Nutrient Absorption after Cimetidine in Short-Bowel Syndrome with Gastric Hypersecretion

1979 • 94 citations

SOME in vitro AND in vivo ACTIONS OF THE NEW HISTAMINE H₂‐RECEPTOR ANTAGONIST, RANITIDINE

1981 • 88 citations

Malabsorption of protein-bound cobalamin but not unbound cobalamin during cimetidine administration

1980 • 88 citations

Cimetidine in treatment of reflux oesophagitis with peptic stricture.

1979 • 88 citations

Cimetidine affords protection equal to antacids in prevention of stress ulceration following thermal injury.

1979 • 83 citations

EFFECT OF CIMETIDINE ON GASTRIC JUICE N-NITROSAMINE CONCENTRATION

1981 • 80 citations

Double-blind comparison of cimetidine and placebo in the maintenance of healing of chronic duodenal ulceration.

1979 • 77 citations

N-NITROSO COMPOUNDS: A PERSPECTIVE ON HUMAN EXPOSURE

1983 • 77 citations

The effect of an H2-receptor antagonist on food-stimjlated acid secretion, serum gastrin, and gastric emptying in patients with duodenal ulcers. Comparison with an anticholinergic drug.

1975 • 73 citations

Comparison of ranitidine and cimetidine in the inhibition of histamine, sham-feeding, and meal-induced gastric secretion in duodenal ulcer patients.

1980 • 73 citations

Pharmacokinetics of the H2‐ receptor antagonist ranitidine in man.

1981 • 69 citations

MODEL OF MEDICAL TREATMENT FOR DUODENAL ULCER

1981 • 68 citations

Histamine as a Physiological Excitant of Acid Gastric Secretion.

1944 • 65 citations

Control of Gastric Secretion: No Room for Histamine?

1971 • 64 citations

INHIBITION OF NOCTURNAL ACID SECRETION IN DUODENAL ULCER BY ONE ORAL DOSE OF METIAMIDE

1974 • 62 citations

Metiamide, an H₂-Receptor Blocker, as Inhibitor of Basal and Meal-Stimulated Gastric Acid Secretion in Patients with Duodenal Ulcer

1974 • 62 citations

Postprandial gastric, pancreatic, and biliary response to histamine H2-receptor antagonists active duodenal ulcer.

1977 • 62 citations

Return to work and quality of life after surgery for coronary artery disease.

1979 • 60 citations

The Pharmacokinetic Basis for H2-antagonist Drug Interactions

1983 • 58 citations

Effect of cimetidine on intrinsic factor and pepsin secretion in man

1978 • 56 citations

Postprandial Gastric, Pancreatic, and Biliary Response to Histamine H2-Receptor Antagonists In Active Duodenal Ulcer

1977 • 54 citations

Effect of metiamide, a histamine H2-receptor antagonist, on gastric response to histamine, pentagastrin, insulin, and peptone meal in man

1974 • 52 citations

HEALING OF GASTRIC ULCER DURING TREATMENT WITH CIMETIDINE

1976 • 50 citations

Gastric Response to Metiamide

1974 • 50 citations

GASTRIN STUDIES

1920 • 46 citations

Effect of Histamine H2-Receptor Blockade on Vagally Induced Gastric Secretion in Man

1974 • 43 citations

Prophylactic Effect of Cimetidine in Gastric Ulcer Patients

1979 • 42 citations

Relief of duodenal ulcer sysmptons by oral metiamide.

1975 • 41 citations

Treatment of duodenal ulcer by metiamide

1975 • 40 citations

Relapse rate of duodenal ulcer after cessation of long-term cimetidine treatment

1980 • 40 citations

Prenatal and Neonatal Exposure of Male Rat Pups to Cimetidine But Not Ranitidine Adversely Affects Subsequent Adult Sexual Functioning

1984 • 35 citations

Aspects of the effect of metiamide on pentagastrin-stimulated and basal gastric secretion of acid and pepsin in man.

1975 • 33 citations

HISTAMINE CONTENT OF CANINE GASTRIC JUICE

1947 • 31 citations

Ranitidine in acute upper gastrointestinal haemorrhage.

1982 • 31 citations

Effect of ranitidine, a new H2-antagonist, on gastric and pancreatic secretion in duodenal ulcer patients

1980 • 28 citations

THE EFFECT OF ANTIHISTAMINE SUBSTANCES ON GASTRIC SECRETION IN MAN

1949 • 27 citations

CIMETIDINE IN THE PREVENTION OF THE PULMONARY ACID ASPIRATION (MENDELSON'S) SYNDROME

1979 • 27 citations

THE ABNORMAL FUNCTIONING OF THE GASTRIC SECRETORY MECHANISM AS A POSSIBLE FACTOR IN THE PATHOGENESIS OF PEPTIC ULCER.

1938 • 25 citations

Use of ranitidine in the medical treatment of Zollinger-Ellison syndrome.

1981 • 24 citations

Cimetidine affords protection equal to antacids in prevention of stress ulceration following thermal injury

1980 • 24 citations

Effect of Cimetidine on Pentagastrin-stimulated Gastric Acid and Pepsin Secretion before and after 6 Weeks of Cimetidine Treatment

1978 • 23 citations

Cimetidine-induced acute interstitial nephritis.

1982 • 22 citations

Gastric Secretion in Dogs Treated with Histamine Antagonist, Thymoxyethyldiethylamine

1941 • 21 citations

Ranitidine in acute upper gastrointestinal haemorrhage

1982 • 19 citations

THE EFFECT ON GASTRIC SECRETION OF DIFFERENT RATES OF HISTAMINE INFUSION AND OF “NEOANTERGAN”

1948 • 16 citations

Inhibitory effect of cimetidine on gastric acid secretion vagally activated by physiological means in duodenal ulcer patients.

1978 • 16 citations

In vitro actions of ranitidine, a new histamine H2-receptor antagonist

1980 • 15 citations

24 hour intragastric acidity during maintenance treatment with ranitidine.

1984 • 15 citations

Is intrinsic factor really affected by cimetidine?

1979 • 14 citations

Some results of the gastric secretory response of patients having duodenal ulcer noted during the administration of benadryl.

1946 • 14 citations

The Effect of β‐dimethylaminoethyl Benzhydryl Ether Hydrochloride on Histamine‐Induced Gastric Secretion in the Cat.

1947 • 12 citations

Kinetics and duration of action of ranitidine on gastric secretion and its effect on pancreatic secretion in duodenal ulcer patients.

1981 • 11 citations

Long-term cimetidine and anticholinergic therapy in patients with gastrinoma

1979 • 10 citations

Side Effects of Histamine2-Receptor Antagonists

1983 • 9 citations

EFFECT OF BENADRYL ON GASTRIC ACIDITY

1947 • 6 citations

Oral metiamide as an effective inhibitor of gastric acid secretion in man.

1974 • 6 citations

Protein synthesis inhibitors and gastric acid secretion

1978 • 5 citations