A meta-analysis of randomized trials for the treatment of nonalcoholic fatty liver disease

Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement.

2009 • 44,660 citations

Meta-Analysis: High-Dosage Vitamin E Supplementation May Increase All-Cause Mortality

2005 • 2,499 citations

A Placebo-Controlled Trial of Pioglitazone in Subjects with Nonalcoholic Steatohepatitis

2006 • 1,700 citations

Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis

2009 • 1,221 citations

The Look AHEAD Study: A Description of the Lifestyle Intervention and the Evidence Supporting It

2006 • 790 citations

Ursodeoxycholic acid for treatment of nonalcoholic steatohepatitis: Results of a randomized trial

2004 • 723 citations

Vitamin E and vitamin C treatment improves fibrosis in patients with nonalcoholic steatohepatitis

2003 • 704 citations

A Randomized Controlled Trial of Metformin versus Vitamin E or Prescriptive Diet in Nonalcoholic Fatty Liver Disease

2005 • 684 citations

Aerobic exercise training reduces hepatic and visceral lipids in obese individuals without weight loss

2009 • 613 citations

Rosiglitazone for Nonalcoholic Steatohepatitis: One-Year Results of the Randomized Placebo-Controlled Fatty Liver Improvement With Rosiglitazone Therapy (FLIRT) Trial

2008 • 597 citations

Effects of Rosiglitazone and Metformin on Liver Fat Content, Hepatic Insulin Resistance, Insulin Clearance, and Gene Expression in Adipose Tissue in Patients With Type 2 Diabetes

2004 • 530 citations

Systematic review of risk factors for fibrosis progression in non-alcoholic steatohepatitis

2009 • 526 citations

Cytokines and NASH: A pilot study of the effects of lifestyle modification and vitamin E

2003 • 523 citations

Liver abnormalities in severely obese subjects: Effect of drastic weight loss after gastroplasty

1998 • 499 citations

Effect of Bariatric Surgery on Nonalcoholic Fatty Liver Disease: Systematic Review and Meta-Analysis

2008 • 495 citations

Randomized, Placebo-Controlled Trial of Pioglitazone in Nondiabetic Subjects With Nonalcoholic Steatohepatitis

2009 • 494 citations

Prospective Study of the Long-Term Effects of Bariatric Surgery on Liver Injury in Patients Without Advanced Disease

2009 • 469 citations

Orlistat for overweight subjects with nonalcoholic steatohepatitis: A randomized, prospective trial

2008 • 453 citations

A pilot study of vitamin E versus vitamin E and pioglitazone for the treatment of nonalcoholic steatohepatitis

2004 • 438 citations

Dietary Fat and Carbohydrates Differentially Alter Insulin Sensitivity During Caloric Restriction

2009 • 415 citations

Metformin in the treatment of patients with non‐alcoholic steatohepatitis

2004 • 409 citations

Lifestyle intervention and antioxidant therapy in children with nonalcoholic fatty liver disease: A randomized, controlled trial

2008 • 399 citations

Long-Term Efficacy of Rosiglitazone in Nonalcoholic Steatohepatitis: Results of the Fatty Liver Improvement by Rosiglitazone Therapy (Flirt 2) Extension Trial

2009 • 352 citations

Randomized Placebo-Controlled Trial of Ursodeoxycholic Acid With Vitamin E in Nonalcoholic Steatohepatitis

2006 • 347 citations

An Assessment of Statin Safety by Hepatologists

2006 • 342 citations

Surgically-Induced Weight Loss Significantly Improves Nonalcoholic Fatty Liver Disease and the Metabolic Syndrome

2005 • 337 citations

A Double-Blind Randomized Placebo-Controlled Trial of Orlistat for the Treatment of Nonalcoholic Fatty Liver Disease

2006 • 312 citations

Metformin in patients with non-alcoholic fatty liver disease: A randomized, controlled trial

2009 • 309 citations

Independent effects of physical activity in patients with nonalcoholic fatty liver disease

2009 • 307 citations

Effects of n-3 polyunsaturated fatty acids in subjects with nonalcoholic fatty liver disease

2007 • 280 citations

Statins in non-alcoholic fatty liver disease and chronically elevated liver enzymes: A histopathological follow-up study

2007 • 268 citations

A Pilot Study Using Simvastatin in the Treatment of Nonalcoholic Steatohepatitis

2009 • 261 citations

Importance of changes in adipose tissue insulin resistance to histological response during thiazolidinedione treatment of patients with nonalcoholic steatohepatitis

2009 • 259 citations

Effect of multifactorial treatment on non-alcoholic fatty liver disease in metabolic syndrome: a randomised study

2006 • 246 citations

The effects of discontinuing pioglitazone in patients with nonalcoholic steatohepatitis

2007 • 238 citations

Statins and Liver Toxicity: A Meta‐Analysis

2004 • 217 citations

L-Carnitine Supplementation to Diet: A New Tool in Treatment of Nonalcoholic Steatohepatitis—A Randomized and Controlled Clinical Trial

2010 • 216 citations

Betaine for nonalcoholic fatty liver disease: Results of a randomized placebo-controlled trial

2009 • 210 citations

Non‐alcoholic fatty liver disease from pathogenesis to management: an update

2009 • 193 citations

Effect of Rimonabant on the High-Triglyceride/ Low–HDL-Cholesterol Dyslipidemia, Intraabdominal Adiposity, and Liver Fat

2008 • 192 citations

Effects of n-3 polyunsaturated fatty acids from seal oils on nonalcoholic fatty liver disease associated with hyperlipidemia

2008 • 178 citations

Angiotensin-receptor blockers as therapy for mild-to-moderate hypertension-associated non-alcoholic steatohepatitis

2009 • 170 citations

Omega-3 Fatty Acid Supplementation Decreases Liver Fat Content in Polycystic Ovary Syndrome: A Randomized Controlled Trial Employing Proton Magnetic Resonance Spectroscopy

2009 • 168 citations

Pioglitazone versus vitamin E versus placebo for the treatment of non-diabetic patients with non-alcoholic steatohepatitis: PIVENS trial design

2008 • 158 citations

Statins and hepatic steatosis: Perspectives from the Dallas Heart Study

2006 • 156 citations

The effect of metformin and standard therapy versus standard therapy alone in nondiabetic patients with insulin resistance and nonalcoholic steatohepatitis (NASH): a pilot trial

2009 • 137 citations

Probucol in the treatment of non-alcoholic steatohepatitis: a double-blind randomized controlled study

2003 • 135 citations

Clinical trial: insulin‐sensitizing agents may reduce consequences of insulin resistance in individuals with non‐alcoholic steatohepatitis

2008 • 120 citations

Efficacy of insulin-sensitizing agents in nonalcoholic fatty liver disease

2009 • 114 citations

Efficacy and Safety of Oral Betaine Glucuronate in Non-alcoholic Steatohepatitis

2011 • 105 citations

Clinical trial: a nutritional supplement Viusid, in combination with diet and exercise, in patients with nonalcoholic fatty liver disease

2009 • 98 citations

The effect of metformin on leptin in obese patients with type 2 diabetes mellitus and nonalcoholic fatty liver disease

2008 • 87 citations

Management of fatty liver disease with vitamin E and C compared to ursodeoxycholic acid treatment.

2005 • 78 citations

A randomized controlled pilot study of Pentoxifylline in patients with non-alcoholic steatohepatitis (NASH)

2008 • 73 citations

Weight reduction and ursodeoxycholic acid in subjects with nonalcoholic fatty liver disease. A double-blind, placebo-controlled trial

2004 • 66 citations

Methods for assessing intrahepatic fat content and steatosis

2009 • 45 citations

Multivariate analysis of risk factors for the development of type 2 diabetes in nonalcoholic fatty liver disease

2009 • 43 citations

A randomized double-blind study of the short-time treatment of obese patients with nonalcoholic fatty liver disease with ursodeoxycholic acid

2003 • 39 citations

Thiazolidinediones for the Treatment in NASH

2009 • 26 citations

563 Pentoxifylline Improves ALT and Histology in Patients with NASH, a Double Blind Placebo Controlled Trial

2009 • 13 citations

[701] PENTOXIFYLLINE FOR TREATMENT OF NONALCOHOLIC FATTY LIVER DISEASE (NAFLD): A RANDOMIZED, PLACEBO-CONTROLLED STUDY

2007 • 11 citations

47 A MULTICENTRIC, DOUBLE-BLIND, RANDOMISED- CONTROLLED TRIAL (RCT) OF HIGH DOSE URSODEOXYCHOLIC ACID IN PATIENTS WITH NON-ALCOHOLIC STEATOHEPATITIS (NASH)

2009 • 8 citations