Anti-allergic properties of cyclosporin A: inhibition of mediator release from human basophils and rat basophilic leukemia cells (RBL-2H3)

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Inositol trisphosphate and diacylglycerol as second messengers

1984 • 3,535 citations

Cyclophilin: A Specific Cytosolic Binding Protein for Cyclosporin A

1984 • 1,670 citations

Biological effects of cyclosporin A: A new antilymphocytic agent

1976 • 1,501 citations

Peptidyl-prolyl cis-trans isomerase is the cyclosporin A-binding protein cyclophilin

1989 • 1,087 citations

A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin

1989 • 1,010 citations

Cyclosporin A mediates immunosuppression of primary cytotoxic T cell responses by impairing the release of interleukin 1 and interleukin 2

1981 • 632 citations

Calcium Ionophores and Movement of Calcium Ions following the Physiological Stimulus to a Secretory Process

1973 • 631 citations

Cyclosporin A inhibits T-cell growth factor gene expression at the level of mRNA transcription.

1984 • 623 citations

IgE‐induced histamine release from rat basophilic leukemia cell lines: isolation of releasing and nonreleasing clones

1981 • 586 citations

The effects of substance P on histamine and 5‐hydroxytryptamine release in the rat

1982 • 347 citations

Cyclosporin A Binding to Calmodulin: A Possible Site of Action on T Lymphocytes

1985 • 282 citations

TREATMENT OF INTRAOCULAR INFLAMMATORY DISEASE WITH CYCLOSPORIN A

1983 • 237 citations

THE INTERACTION OF IgE WITH RAT BASOPHILIC LEUKEMIA CELLS

1974 • 236 citations

Cyclosporin A - Usefulness, Risks and Mechanism of Action

1982 • 209 citations

Activation of a human T cell line: a two-stimulus requirement in the pretranslational events involved in the coordinate expression of interleukin 2 and gamma-interferon genes.

1985 • 203 citations

Selective inhibitors of Ca2+-binding modulator of phosphodiesterase produce vascular relaxation and inhibit actin-myosin interaction.

1979 • 201 citations

Biochemistry of the acute allergic reactions

1969 • 190 citations

Synergistic action of protein kinase C and calcium for histamine release from rat peritoneal mast cells

1984 • 179 citations

Cyclosporin A in cadaveric organ transplantation.

1981 • 134 citations

Basophilic Leukaemia in the Albino Rat and a Demonstration of the Basopoietin

1973 • 132 citations

CYCLOSPORIN A

1981 • 128 citations

The purification of human basophils.

1980 • 106 citations

On the calcium receptor activating exocytosis: inhibitory effects of calmodulin‐interacting drugs on rat mast cells.

1982 • 105 citations

Release of Slow Reacting Substance of Anaphylaxis (Srs-A) from Human Leukocytes by the Calcium Ionophore A23187

1976 • 100 citations

Calcium and calmodulin antagonists inhibit human malaria parasites (Plasmodium falciparum): implications for drug design.

1987 • 100 citations

Selective suppression of an early step in human B cell activation by cyclosporin A.

1983 • 96 citations

Release of histamine from human leukocytes stimulated with the tumor-promoting phorbol diesters. I. Characterization of the response.

1981 • 95 citations

Mechanism of Action of Concanvalin A on Human Basophils

1975 • 95 citations

Stimulation and Inhibition of Histamine Release from Isolated Rat Mast Cells

1975 • 80 citations

Inhibition of IgE-mediated histamine release from rat basophilic leukemia cells and rat mast cells by inhibitors of transmethylation.

1981 • 77 citations

Effects of cyclosporin A on the immune system of the mouse. I. Evidence for a direct selective effect of cyclosporin A on B cells responding to anti‐immunoglobulin antibodies

1982 • 77 citations

Does the Binding of Cyclosporine to Calmodulin Result in Immunosuppression?

1986 • 75 citations

Inhibition of Histamine and Prostaglandin D<sub>2</sub> Release from Human Lung Mast Cells by Ciclosporin A

1989 • 71 citations

Cyclosporin A: in vivo and in vitro suppression of rat T-lymphocyte function.

1979 • 67 citations

CYCLOSPORINE DOES NOT PREVENT CYTOPLASMIC CALCIUM CHANGES ASSOCIATED WITH LYMPHOCYTE ACTIVATION

1984 • 62 citations

Biochemical characterization of the inhibitory effect of CsA on cytolytic T lymphocyte effector functions.

1989 • 59 citations

Identification of cyclophilin as the erythrocyte ciclosporin-binding protein

1988 • 48 citations

Restoration of Ca ²⁺ influx and degranulation capacity of variant RBL-2H3 cells upon implantation of isolated cromolyn binding protein

1983 • 47 citations

Calmodulin and Intracellular Ca++ Receptors

1982 • 44 citations

CYCLOSPORINE IN HUMAN BONE MARROW TRANSPLANTATION SEKUM CONCENTRATION, GRAFT-VERSUS-HOST DISEASE, AND NEPHROTOXICITY

1983 • 44 citations

Slow reacting substances: comparison of some properties of human lung SRS-A and two distinct fractions from ionophore-induced rat mononuclear cell SRS.

1979 • 40 citations

Inhibitory Effect of Cyclosporin A on Histamine Release from Human Leukocytes and Rat Mast Cells

1985 • 35 citations

Slow Reacting Substances: Comparison of Some Properties of Human Lung SRS-A and Two Distinct Fractions from Ionophore-Induced Rat Mononuclear Cell SRS

1979 • 34 citations

Mechanism of action of concanavalin A on human basophils.

1975 • 31 citations

Biopharmacological Assessment of Calmodulin Function: Utility of Calmodulin Antagonists

1982 • 26 citations

Mechanism of action of cyclosporine: role of calmodulin, cyclophilin, and other cyclosporine-binding proteins.

1986 • 26 citations

Calmodulin antagonism: A pharmacological approach for the inhibition of mediator release from mast cells

1987 • 25 citations

Possible role of calmodulin in the control of histamine release from human basophil leukocytes

1986 • 24 citations

Plenary lecture Mechanism of signal transduction in mast cells and basophils: Studies with RBL-2H3 cells

1987 • 19 citations

Effect of cyclosporin A and inhibitors of arachidonic acid metabolism on blood flow and cyclo‐oxygenase products in rat skin allografts

1984 • 19 citations

Calmodulin in mast cells and its role in histamine secretion

1985 • 17 citations

Cyclosporin A (Sandimmun®) modulates the Ca2+ uptake of mitogen-stimulated lymphocytes

1984 • 14 citations

Inhibition of histamine release from human lung and rat peritoneal mast cells by cyclosporin-A

1990 • 14 citations

BLOOD FLOW, HISTAMINE CONTENT AND HISTIDINE DECARBOXYLASE ACTIVITY IN RAT SKIN GRAFTS AND THEIR MODIFICATION BY CYCLOSPORIN‐A

1982 • 13 citations

Effect of cyclosporin A on rat mucosal mast cells and the associated protease RMCPII.

1988 • 12 citations

Stimulus-secretion coupling in rat basophilic leukemia cells.

1981 • 11 citations