Phase II Study of Perifosine in Previously Untreated Patients with Metastatic Melanoma

New Guidelines to Evaluate the Response to Treatment in Solid Tumors

2000 • 15,583 citations

High-dose recombinant interleukin-2 therapy in patients with metastatic melanoma: long-term survival update.

2000 • 500 citations

Perifosine, a novel alkylphospholipid, inhibits protein kinase B activation.

2003 • 399 citations

Sequential Biochemotherapy Versus Chemotherapy for Metastatic Melanoma: Results From a Phase III Randomized Trial

2002 • 378 citations

The p16-cyclin D/Cdk4-pRb pathway as a functional unit frequently altered in melanoma pathogenesis.

1996 • 278 citations

Prognostic factors for survival of patients treated systemically for disseminated melanoma.

1998 • 222 citations

Randomized phase III trial of treatment with high-dose interleukin-2 either alone or in combination with interferon alfa-2a in patients with advanced melanoma.

1993 • 181 citations

Phase I and pharmacological study of daily oral administration of perifosine (D-21266) in patients with advanced solid tumours

2002 • 158 citations

D-21266, a new heterocyclic alkylphospholipid with antitumour activity

1997 • 133 citations

Perifosine, a novel alkylphospholipid, induces p21(WAF1) expression in squamous carcinoma cells through a p53-independent pathway, leading to loss in cyclin-dependent kinase activity and cell cycle arrest.

2002 • 103 citations

The inhibition of cell signaling pathways by antitumor ether lipids

1998 • 97 citations

Application of a New Multinomial Phase II Stopping Rule Using Response and Early Progression

2001 • 76 citations

Metabolism of ether phospholipids and analogs in neoplastic cells

1987 • 70 citations

Transcriptional Activation of p21waf1/cip1 by Alkylphospholipids

2004 • 70 citations

Tumor Cytotoxicity of Human Macrophages After Incubation With Synthetic Analogues of 2-Lysophosphatidylcholine2

1984 • 51 citations

Effects of miltefosine on various biochemical parameters in a panel of tumor cell lines with different sensitivities 2 2Abbreviations: D-21266, octadecyl-(N,N-dimethyl-piperidino-4-yl)-phosphate; HeLa-WT, HeLa wild-type cells, HeLa-MDR1-G185, HeLa-WT cells transfected with a wild-type MDR1 gene containing glycine in position 185; HeLa-MDR1-V185, HeLa wild-type cells transfected with a mutant MDR1 gene containing valine in position 185; HL-60, human promyelocytic leukemia cells; MDR1, multidrug …

2001 • 44 citations

Melanomas, from the cell cycle point of view (Review).

1998 • 33 citations

Alkylphospholipids reversibly open epithelial tight junctions.

2003 • 17 citations