Relative effects of aspirin on platelet aggregation and prostaglandin-mediated coronary vasodilatation in the dog.

An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation

1976 • 3,613 citations

Aspirin Selectively Inhibits Prostaglandin Production in Human Platelets

1971 • 1,535 citations

Arterial walls are protected against deposition of platelet thrombi by a substance (prostaglandin X) which they make from prostaglandin endoperoxides

1976 • 1,012 citations

Acetylation of prostaglandin synthase by aspirin.

1975 • 1,003 citations

Platelet aggregation in partially obstructed vessels and its elimination with aspirin.

1976 • 765 citations

Inhibition of platelet prostaglandin synthetase by oral aspirin.

1978 • 552 citations

Platelet Aggregation induced by Arachidonic Acid is accompanied by Release of Potential Inflammatory Mediators distinct from PGE2 and PGF2

1973 • 227 citations

Cultured human skin fibroblasts and arterial cells produce a labile platelet-inhibitory prostaglandin

1977 • 209 citations

Sensitivity of fatty acid cyclooxygenase from human aorta to acetylation by aspirin.

1978 • 150 citations

Prostaglandins and the control of blood flow in the canine myocardium.

1977 • 111 citations

Paradoxical endogenous synthesis of a coronary dilating substance from arachidonate

1976 • 110 citations

Transformation of arachidonic acid and prostaglandin endoperoxides by the guinea pig heart. Formation of RCS and prostacyclin

1978 • 96 citations

Effects of Arachidonic Acid on Systemic Arterial Pressure, Myocardial Contractility and Platelets in the Dog

1974 • 53 citations

Prostacyclin and thromboxane generating systems in rabbits pretreated with aspirin

1978 • 29 citations

Platelets in Thrombosis Their Clinical Significance and the Evaluation of Potential Drugs

1974 • 11 citations

Platelets and the vascular responses to arachidonic acid in dogs

1977 • 9 citations