Mutagenesis and peptide analysis of the DRY motif in the α2A adrenergic receptor: evidence for alternate mechanisms in G protein-coupled receptors

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Advances in Determination of a High-Resolution Three-Dimensional Structure of Rhodopsin, a Model of G-Protein-Coupled Receptors (GPCRs)^,

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1992 • 307 citations

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1991 • 221 citations

Constitutive activation of opsin: Influence of charge at position 134 and size at position 296

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Mutation of a Highly Conserved Aspartic Acid in the β₂Adrenergic Receptor: Constitutive Activation, Structural Instability, and Conformational Rearrangement of Transmembrane Segment 6

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1989 • 152 citations

The Second Intracellular Loop of the m5 Muscarinic Receptor Is the Switch Which Enables G-protein Coupling

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Activation Mechanism of Human Oxytocin Receptor: A Combined Study of Experimental and Computer-Simulated Mutagenesis

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Two peptides from the alpha 2A-adrenergic receptor alter receptor G protein coupling by distinct mechanisms

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Multisite contacts involved in coupling of the β‐adrenergic receptor with the stimulatory guanine‐nucleotide‐binding regulatory protein

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1995 • 67 citations

G_iActivator Region of α_2A-Adrenergic Receptors: Distinct Basic Residues Mediate G_iversus G_sActivation

1999 • 67 citations

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Inverse Agonist Activity at the α_2A-Adrenergic Receptor

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Structural requirements for G(o) activation by receptor-derived peptides: activation and modulation domains of the alpha 2-adrenergic receptor i3c region.

1996 • 44 citations

Rhodopsin Arginine-135 Mutants Are Phosphorylated by Rhodopsin Kinase and Bind Arrestin in the Absence of 11-cis-Retinal

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NMR Structure of the Second Intracellular Loop of the α2A Adrenergic Receptor: Evidence for a Novel Cytoplasmic Helix^,

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Secondary Structure of Bacteriorhodopsin Fragments

1998 • 29 citations