Infection of human hepatocyte chimeric mouse with genetically engineered hepatitis B virus

Hepatitis B Virus Infection — Natural History and Clinical Consequences

2004 • 2,271 citations

Hepatitis C virus replication in mice with chimeric human livers

2001 • 870 citations

A Preliminary Trial of Lamivudine for Chronic Hepatitis B Infection

1995 • 820 citations

High-level hepatitis B virus replication in transgenic mice

1995 • 625 citations

Near Completely Humanized Liver in Mice Shows Human-Type Metabolic Responses to Drugs

2004 • 528 citations

Selection of mutations in the hepatitis B virus polymerase during therapy of transplant recipients with lamivudine

1996 • 470 citations

Mutation in HBV RNA-dependent DNA polymerase confers resistance to lamivudinein vivo

1996 • 454 citations

Repopulation of mouse liver with human hepatocytes and in vivo infection with hepatitis B virus

2001 • 391 citations

Emergence and takeover of YMDD motif mutant hepatitis B virus during long-term lamivudine therapy and re-takeover by wild type after cessation of therapy

1998 • 378 citations

Morphological and biochemical characterization of a human liver in a uPA-SCID mouse chimera

2005 • 358 citations

Lamivudine resistance inimmunocompetent chronic hepatitis B

1997 • 276 citations

Clinical aspects of hepatitis B virus infection

1993 • 223 citations

Hepatitis B Virus and Hepatocellular Carcinoma

1986 • 214 citations

A critical role for the chimpanzee model in the study of hepatitis C

2004 • 180 citations

Mutation in HBV RNA-dependent DNA polymerase confers resistance to lamivudine in vivo

1996 • 173 citations

Cloned HBV DNA causes hepatitis in chimpanzees

1982 • 149 citations

Liver repopulation with xenogenic hepatocytes in B and T cell-deficient mice leads to chronic hepadnavirus infection and clonal growth of hepatocellular carcinoma

1998 • 122 citations

The Complete Nucleotide Sequence of a Pre-core Mutant of Hepatitis B Virus Implicated in Fulminant Hepatitis and Its Biological Characterization in Chimpanzees

1993 • 120 citations

The hepatitis B virus-trimera mouse: A model for human HBV infection and evaluation of anti-HBV therapeutic agents

1999 • 98 citations

Amplification of Full-Length Hepatitis B Virus Genomes from Samples from Patients with Low Levels of Viremia: Frequency and Functional Consequences of PCR-Introduced Mutations

1998 • 88 citations

A long-term hepatitis B viremia model generated by transplanting nontumorigenic immortalized human hepatocytes in Rag-2-deficient mice

2000 • 83 citations

In vivo neutralization of hepatitis B virus infection by an anti-preS1 humanized antibody in chimpanzees

2003 • 74 citations

Chronic infection with hepatitis B viruses and antiviral drug evaluation in uPA mice after liver repopulation with tupaia hepatocytes

2004 • 73 citations

Transcriptional and posttranscriptional control of hepatitis B virus gene expression

2003 • 72 citations

Histological improvement in patients with chronic hepatitis B virus infection treated with lamivudine

1997 • 66 citations

Chimpanzee models for human disease and immunobiology

2001 • 41 citations

Oligomer synthesis by priming deficient polymerase in hepatitis B virus core particle

2004 • 40 citations

Different Procarcinogenic Potentials of Lymphocyte Subsets in a Transgenic Mouse Model of Chronic Hepatitis B

2004 • 30 citations

Clinical virology of hepatitis B virus infection

2003 • 28 citations

Idiopathic Hemochromotosis and Alpha-1-Antitrypsin Deficiency: Coexistence in a Family with Progressive Liver Disease in the Proband

1983 • 27 citations

Anti-Hepatitis B Virus Activity of ORI-9020, a Novel Phosphorothioate Dinucleotide, in a Transgenic Mouse Model

2004 • 23 citations

The Chimpanzee Model: Contributions and Considerations for Studies of Hepatitis B Virus

2004 • 10 citations