Anti-CD74 Antibody-Doxorubicin Conjugate, IMMU-110, in a Human Multiple Myeloma Xenograft and in Monkeys

Tissue sulfhydryl groups

1959 • 25,130 citations

MIF Signal Transduction Initiated by Binding to CD74

2003 • 1,031 citations

Assembly, Transport, and Function of MHC Class II Molecules

1994 • 791 citations

Internalizing antibodies are necessary for improved therapeutic efficacy of antibody-targeted liposomal drugs.

2002 • 244 citations

P-glycoprotein expression in human plasma cell myeloma: correlation with prior chemotherapy

1993 • 207 citations

P-glycoprotein expression in plasma-cell myeloma is associated with resistance to VAD

1989 • 162 citations

CD74 Is Expressed by Multiple Myeloma and Is a Promising Target for Therapy

2004 • 158 citations

Antiproliferative activity of a humanized anti-CD74 monoclonal antibody, hLL1, on B-cell malignancies

2004 • 141 citations

Circulating monoclonal B cells expressing P glycoprotein may be a reservoir of multidrug-resistant disease in multiple myeloma

1994 • 118 citations

Invariant Chain Induces B Cell Maturation by Activating a TAFII105-NF-κB-dependent Transcription Program

2001 • 111 citations

Internalization and catabolism of radiolabelled antibodies to the MHC class-II invariant chain by B-cell lymphomas

1996 • 93 citations

A Phase II trial of pegylated liposomal doxorubicin, vincristine, and reduced‐dose dexamethasone combination therapy in newly diagnosed multiple myeloma patients

2002 • 84 citations

Adriamycin(hydrazone)-antibody conjugates require internalization and intracellular acid hydrolysis for antitumor activity

1991 • 80 citations

Cure of SCID mice bearing human B-lymphoma xenografts by an anti-CD74 antibody-anthracycline drug conjugate.

2003 • 79 citations

MDR-1 expression and response to vincristine, doxorubicin, and dexamethasone chemotherapy in multiple myeloma refractory to alkylating agents.

1994 • 75 citations

Radionuclides linked to a CD74 antibody as therapeutic agents for B-cell lymphoma: comparison of Auger electron emitters with beta-particle emitters.

2000 • 66 citations

Cytotoxicity with Auger electron-emitting radionuclides delivered by antibodies

1999 • 62 citations

Prodrug chemotherapeutics bypass p-glycoprotein resistance and kill tumors in vivo with high efficacy and target-dependent selectivity

2004 • 55 citations

Preclinical Therapy of Breast Cancer with a Radioiodinated Humanized Anti-EGP-1 Monoclonal Antibody: Advantage of a Residualizing Iodine Radiolabel

2004 • 49 citations

Cellular association and cytotoxicity of anti-CD74-targeted lipid drug-carriers in B lymphoma cells

2003 • 49 citations

Disposition of conjugate-bound and free doxorubicin in tumor-bearing mice following administration of a BR96-doxorubicin immunoconjugate (BMS 182248)

1997 • 37 citations

Selection of a dtpa chelate conjugate for monoclonal antibody targeting to a human colonic tumor in nude mice

1990 • 34 citations

Circulating monoclonal B cells expressing P glycoprotein may be a reservoir of multidrug-resistant disease in multiple myeloma

1994 • 9 citations