Inhibition of tyrosine phosphorylation potentiates substrate‐induced neurite growth

Genistein, a specific inhibitor of tyrosine-specific protein kinases.

1987 • 3,773 citations

Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice

1991 • 2,028 citations

The trk proto-oncogene encodes a receptor for nerve growth factor

1991 • 1,396 citations

High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor

1991 • 1,232 citations

Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF

1991 • 1,049 citations

GPI-Anchored Cell-Surface Molecules Complexed to Protein Tyrosine Kinases

1991 • 848 citations

Association between the PDGF receptor and members of the src family of tyrosine kinases

1990 • 650 citations

Increase of the Catalytic Activity of Phospholipase C-γ1 by Tyrosine Phosphorylation

1990 • 650 citations

Vinculin: A cytoskeletal target of the transforming protein of rous sarcoma virus

1981 • 591 citations

Peptides and Protein Phosphorylation

2018 • 525 citations

Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors

1991 • 520 citations

Rapid activation of the T-cell tyrosine protein kinase pp56lck by the CD45 phosphotyrosine phosphatase.

1989 • 425 citations

L1-mediated axon outgrowth occurs via a homophilic binding mechanism

1989 • 423 citations

Genetic analysis of a drosophila neural cell adhesion molecule: Interaction of fasciclin I and abelson tyrosine kinase mutations

1990 • 340 citations

Pervanadate [peroxide(s) of vanadate] mimics insulin action in rat adipocytes via activation of the insulin receptor tyrosine kinase

1989 • 317 citations

Neuronal pp60 ^{c- src} Contains a Six-Amino Acid Insertion Relative to Its Non-Neuronal Counterpart

1987 • 313 citations

Differentiation of PC12 phaeochromocytoma cells induced by v-src oncogene

1985 • 306 citations

Neurite outgrowth in response to transfected N-CAM changes during development and is modulated by polysialic acid

1990 • 299 citations

Evidence that biological activity of NGF is mediated through a novel subclass of high affinity receptors

1991 • 296 citations

Tyrphostins Inhibit Epidermal Growth Factor (EGF)-Receptor Tyrosine Kinase Activity in Living Cells and EGF-Stimulated Cell Proliferation

1989 • 286 citations

Purified N-cadherin is a potent substrate for the rapid induction of neurite outgrowth.

1990 • 273 citations

Molecular Mechanisms of Axon Growth and Guidance

1991 • 263 citations

Isolation of a Novel Tyrosine Kinase Inhibitor, Lavendustin A, from Streptomyces griseolavendus

1989 • 249 citations

Distinct molecular interactions mediate neuronal process outgrowth on non-neuronal cell surfaces and extracellular matrices.

1986 • 240 citations

Drosophila abl tyrosine kinase in embryonic CNS axons: A role in axonogenesis is revealed through dosage-sensitive interactions with disabled

1989 • 240 citations

The participation of a putative cell surface receptor for laminin and fibronectin in peripheral neurite extension

1986 • 223 citations

Three receptor-linked protein-tyrosine phosphatases are selectively expressed on central nervous system axons in the Drosophila embryo

1991 • 212 citations

c-src gene product in developing rat brain is enriched in nerve growth cone membranes.

1988 • 193 citations

Nerve growth factor induces protein-tyrosine phosphorylation.

1988 • 184 citations

A neuronal cell line (PC12) expresses two β1-class integrins—α1β1, and α3β1—that recognize different neurite outgrowth-promoting domains in laminin

1990 • 174 citations

Two Drosophila receptor-like tyrosine phosphatase genes are expressed in a subset of developing axons and pioneer neurons in the embryonic CNS

1991 • 169 citations

Nerve growth factor action is mediated by cyclic AMP- and Ca+2/phospholipid-dependent protein kinases.

1986 • 169 citations

PDGF-Induced Activation of Phospholipase C Is Not Required for Induction of DNA Synthesis

1990 • 158 citations

Protein kinase C is involved in laminin stimulation of neurite outgrowth

1989 • 140 citations

Tubulin is phosphorylated at tyrosine by pp60c-src in nerve growth cone membranes.

1990 • 137 citations

Nerve growth factor and fibroblast growth factor regulate neurite outgrowth and gene expression in PC12 cells via both protein kinase C- and cAMP-independent mechanisms.

1990 • 121 citations

Extracellular matrix molecules and cell adhesion molecules induce neurites through different mechanisms.

1990 • 116 citations

src-related tyrosine protein kinases as signaling components in hematopoietic cells.

1990 • 109 citations

Differential inhibition of T cell receptor signal transduction and early activation events by a selective inhibitor of protein-tyrosine kinase.

1990 • 106 citations

Nerve growth factor receptors in the central nervous system

1988 • 106 citations

pp60c-src kinase is in chick and human embryonic tissues

1984 • 103 citations

Protein modification: phosphorylation on tyrosine residues

1989 • 96 citations

The expression and localization of synaptic vesicle antigens at neuromuscular junctions in vitro

1985 • 82 citations

Characterization of the altered form of the c-src gene product in neuronal cells.

1987 • 75 citations

Isolation of a protein from bovine brain which promotes neurite extension from chick embryo cerebral cortex neurons in defined medium

1982 • 58 citations

Differentiation of PC12 cells with v‐src: Comparison with nerve growth factor

1989 • 55 citations

Inhibition of protein kinase c by the tyrosine kinase inhibitor erbstatin

1990 • 42 citations

Tissue-dependent regulation of protein tyrosine kinase activity during embryonic development.

1991 • 38 citations

Neurite extension and protein tyrosine phosphorylation elicited by inducible expression of the v-src oncogene in a PC12 cell line*1

1991 • 30 citations

Expression of proto-oncogenes in neural tissues

1988 • 26 citations

Tyrosine phosphorylation and immunodetection of vinculin in growth cone particle (GCP) fraction and in GCP-cytoskeletal subfractions

1991 • 13 citations