Folate coenzyme and antifolate transport proteins in normal and neoplastic cells

Carrier-mediated Transport of the Folic Acid Analogue, Methotrexate, in the L1210 Leukemia Cell

1968 • 384 citations

Molecular Actions and Targets for Cancer Chemotherapeutic Agents

1981 • 361 citations

Validation of a recording spectrophotometric method for measurement of membrane-associated Mg- and NaK-ATPase activity.

1979 • 341 citations

THE CHARACTERISTICS OF THE MEMBRANE TRANSPORT OF AMETHOPTERIN AND THE NATURALLY OCCURRING FOLATES

1971 • 291 citations

The cellular pharmacology of methotrexate

1985 • 254 citations

Studies of the role of a particulate folate-binding protein in the uptake of 5-methyltetrahydrofolate by cultured human KB cells.

1985 • 175 citations

Isolation and characterization of a folate receptor from human placenta.

1981 • 164 citations

Obligate genetic expression in tumor cells of a fetal membrane property mediating "folate" transport: biological significance and implications for improved therapy of human cancer.

1985 • 159 citations

Transport and metabolism of methotrexate in normal and resistant cultured rat hepatoma cells.

1979 • 118 citations

The isolation, characterization, and comparison of the membrane-associated and soluble folate-binding proteins from human KB cells.

1986 • 105 citations

Folate Transport by the Choroid Plexus in Vitro

1975 • 97 citations

Intrinsic Resistance to Methotrexate of Cultured Mammalian Cells in Relation to the Inhibition Kinetics of Their Dihydrofolate Reductases

1976 • 91 citations

SITES OF ACTION OF AMETHOPTERIN: INTRINSIC AND ACQUIRED DRUG RESISTANCE*

1971 • 87 citations

Uptake and metabolism of N 5 -formyltetrahydrofolate by L1210 leukemia cells.

1972 • 82 citations

Affinity labeling of the 5-methyltetrahydrofolate/methotrexate transport protein of L1210 cells by treatment with an N-hydroxysuccinimide ester of [3H]methotrexate.

1984 • 82 citations

Changes of molecular properties associated with the development of resistance against methotrexate in human lymphoblastoid cells

1975 • 80 citations

Isolation, characterization, and comparison of the solubilized particulate and soluble folate binding proteins from human milk.

1982 • 80 citations

The influence of extracellular folate concentration on methotrexate uptake by human KB cells. Partial characterization of a membrane-associated methotrexate binding protein.

1986 • 78 citations

The complete amino acid sequence of the folate-binding protein from cow's milk

1984 • 78 citations

Kinetic correlates of methotrexate transport and therapeutic responsiveness in murine tumors.

1976 • 64 citations

Amino acid sequence homology between human and bovine low molecular weight folate binding protein isolated from milk

1982 • 64 citations

Transport of 5-methyltetrahydrofolic acid and folic acid in freshly isolated hepatocytes.

1978 • 61 citations

Properties of a Folate Binding Protein (FBP) isolated from porcine kidney

1986 • 57 citations

Binding properties of the 5-methyltetrahydrofolate/methotrexate transport system in L1210 cells

1980 • 56 citations

Transport of methotrexate in chinese hamster ovary cells: A mutant defective in methotrexate uptake and cell binding

1983 • 55 citations

Purified membrane and soluble folate binding proteins from cultured KB cells have similar amino acid compositions and molecular weights but differ in fatty acid acylation.

1987 • 54 citations

Transport, binding, and polyglutamation of methotrexate in freshly isolated rat hepatocytes.

1980 • 53 citations

Transport of methotrexate by the choroid plexus.

1968 • 53 citations

Identification of folate binding macromolecule in rabbit choroid plexus.

1977 • 53 citations

Membrane transport of methotrexate in human lymphoblastoid cells.

1978 • 52 citations

Characteristics of membrane transport of methotrexate by cultured human breast cancer cells

1981 • 50 citations

Photoaffinity analogs of methotrexate as folate antagonist binding probes. 2. Transport studies, photoaffinity labeling, and identification of the membrane carrier protein for methotrexate from murine L1210 cells

1987 • 49 citations

Further studies on a novel class of genetic variants of the L1210 cell with increased folate analogue transport inward. Transport properties of a new variant, evidence for increased levels of a specific transport protein, and its partial characterization following affinity labeling.

1988 • 48 citations

Rapid isolation and lipid characterization of plasma membranes from normal and malignant lymphoid cells of mouse

1981 • 44 citations

Biochemical correlates of responsiveness and collateral sensitivity of some methotrexate-resistant murine tumors to the lipophilic antifolate, metoprine.

1982 • 40 citations

5-Methyltetrahydrofolate transport by hepatoma cells and methotrexate-resistant sublines in culture.

1981 • 38 citations

The mechanism of folate transport in rabbit reticulocytes

1972 • 38 citations

Amethopterin transport in Ehrlich ascites carcinoma and L1210 cells.

1967 • 37 citations

Characterization of the methotrexate transport defect in a resistant L1210 lymphoma cell line

1981 • 30 citations

Characterization of the methotrexate transport pathway in murine L1210 leukemia cells: involvement of a membrane receptor and a cytosolic protein

1988 • 30 citations

Extent of the requirement for folate transport by L1210 cells for growth and leukemogenesis in vivo.

1985 • 29 citations

Similar specificity of membrane transport for folate analogues and their metabolites by murine and human tumor cells: a clinically directed laboratory study.

1984 • 28 citations

The Mechanism of 5-Methyltetrahydrofolate Transport by Human Erythrocytes

1978 • 27 citations

Partial purification and characterization of a folatebinding protein from human choroid plexus

1981 • 16 citations

Transport of the folate compound methotrexate decreases during differentiation of murine erythroleukemia cells.

1984 • 16 citations

Similar characteristics of folate analogue transport in vitro in contrast to varying dihydrofolate reductase levels in epithelial cells at different stages of maturation in mouse small intestine.

1984 • 16 citations

Photoaffinity analogs of methotrexate as folate antagonist binding probes. 1. Photoaffinity labeling of murine L1210 dihydrofolate reductase and amino acid sequence of the binding region

1987 • 15 citations

MEMBRANE CHARACTERISTICS OF PRIMARY HEPATOCYTE CULTURES AND A STABLE HEPATOCARCINOMA CELL LINE*

1980 • 14 citations

Uptake of methotrexate-3H by rabbit kidney slices.

1967 • 14 citations

Photoaffinity analogues of methotrexate as probes for dihydrofolate reductase structure and function

1986 • 13 citations

Evidence for transfer of folate compounds by a specialized erythrocyte membrane system.

1979 • 13 citations

Comparison of solution structures of dihydrofolate reductases and enzyme-ligand complexes using cross-reacting antibodies

1986 • 9 citations

Photoaffinity analogues of methotrexate as folate antagonist binding probes

1988 • 7 citations