Abnormalities of nerve fibers in the circular muscle of patients with slow transit constipation

Targeted disruption of the neuronal nitric oxide synthase gene

1993 • 1,300 citations

Neurochemical classification of myenteric neurons in the guinea-pig ileum

1996 • 484 citations

Brain Enolases as Specific Markers of Neuronal and Glial Cells

1978 • 464 citations

Radioimmunoassay and characterization of enkephalins in rat tissues.

1978 • 288 citations

Severe Idiopathic Constipation Is Associated With a Distinctive Abnormality of the Colonic Myenteric Plexus

1985 • 286 citations

Evaluation and Surgical Treatment of Severe Chronic Constipation

1991 • 251 citations

A Preliminary Investigation of the Effects of Aging on the Nerve Cell Number in the Myenteric Ganglia of the Human Colon

1997 • 187 citations

Fall in the number of myenteric neurons in aging guinea pigs

1989 • 185 citations

Distribution and coexistence of peptides in nerve fibers of the external muscle of the human gastrointestinal tract

1988 • 173 citations

Evidence for and significance of the projection of VIP neurons from the myenteric plexus to the taenia coli in the guinea pig

1981 • 153 citations

Involvement of nitric oxide in the inhibitory innervation of the human isolated colon

1993 • 141 citations

Constipation with colonic inertia

1983 • 140 citations

Idiopathic chronic constipation is associated with decreased colonic vasoactive intestinal peptide

1988 • 137 citations

NALOXONE, A SPECIFIC OPIOID ANTAGONIST, REVERSES CHRONIC IDIOPATHIC CONSTIPATION

1983 • 134 citations

Age-Induced Nerve Cell Loss in the Myenteric Plexus of the Small Intestine in Man

1993 • 133 citations

Nitric oxide synthase and VIP distribution in enteric nervous system in idiopathic chronic constipation

1995 • 132 citations

Vasoactive intestinal polypeptide levels in sigmoid colon in idiopathic constipation and diverticular disease

1990 • 131 citations

Identification of neurotransmitters regulating intestinal peristaltic reflex in humans

1989 • 129 citations

The neurochemical coding and projections of circular muscle motor neurons in the human colon

1997 • 127 citations

Identification of cholinergic neurons in enteric nervous system by antibodies against choline acetyltransferase

1993 • 127 citations

Radioisotope determination of regional colonic transit in severe constipation: comparison with radio opaque markers.

1993 • 123 citations

Disturbed gastric and small bowel transit in severe idiopathic constipation

1993 • 122 citations

Nitric oxide synthase immunoreactivity in the enteric nervous system of the developing human digestive tract

1994 • 121 citations

Decreased substance P levels in rectal biopsies from patients with slow transit constipation

1996 • 111 citations

Differences in regional brain concentrations of neuropeptide Y in spontaneously hypertensive (SH) and Wistar-Kyoto (WKY) rats

1985 • 108 citations

Anorectal manometric abnormalities and colonic propulsive impairment in patients with severe chronic idiopathic constipation

1994 • 105 citations

Clinical results of colectomy for severe constipation

1989 • 99 citations

The polarity of neurochemically defined myenteric neurons in the human colon

1997 • 94 citations

Choline acetyltransferase immunoreactivity in the human small and large intestine

1996 • 90 citations

Anismus in patients with normal and slow transit constipation

1991 • 83 citations

Upper gastrointestinal motor activity in patients with slow-transit constipation

1996 • 83 citations

Constipation: definition and classification

1968 • 76 citations

Distributions of neuropeptides in the human esophagus

1987 • 74 citations

Tachykinin antagonists inhibit nerve-mediated contractions in the circular muscle of the human ileum

1992 • 73 citations

NK2 tachykinin receptors and contraction of circular muscle of the human colon: characterization of the NK2 receptor subtype

1991 • 71 citations

GABA and nitric oxide synthase immunoreactivities are colocalized in a subset of inhibitory motor neurons of the guinea-pig small intestine

1996 • 70 citations

The intrinsic innervation of the human alimentary tract and its relation to function.

1975 • 66 citations

Impaired colonic motor response to eating in patients with slow-transit constipation.

1992 • 63 citations

Intramural distribution of regulatory peptides in the sigmoid-recto-anal region of the human gut.

1988 • 57 citations

Evidence for a functional cholinergic deficit in human colonic tissue resected for constipation

1988 • 55 citations

Slow transit chronic constipation (Arbuthnot Lane's disease)

1990 • 49 citations

Enkephalins modulate inhibitory neuromuscular transmission in circular muscle of human colon via delta‐opioid receptors.

1990 • 42 citations

Dendritic morphology of presumptive vasoconstrictor and pilomotor neurons and their relations with neuropeptide-containing preganglionic fibres in lumbar sympathetic ganglia of guinea-pigs

1996 • 42 citations

Antibodies Raised Against Synthetic Peptides React with Choline Acetyltransferase in Various Immunoassays and in Immunohistochemistry

1993 • 28 citations

Regulatory role of enteric kappa opioid receptors in human colonic motility

1993 • 26 citations

Abnormalities in the contractile properties of colonic smooth muscle in idiopathic slow transit constipation

1997 • 21 citations

The Effects of Various Peptides on Human Isolated Gut Muscle

1992 • 17 citations

Distribution of neurokinin A-like and neurokinin B-like immunoreactivity in human peripheral tissues

1991 • 16 citations

Effects of long-term treatment with anthranoids and sodium picosulphate on the contents of vasoactive intestinal polypeptide, somatostatin and substance P in the rat colon.

1995 • 14 citations

The distributions and coexistence of peptides in nerve fibres of large bowel affected by Hirschsprung's disease

1991 • 10 citations