Mechanisms of Microsatellite Instability in Colorectal Cancer Patients in Different Age Groups

A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer.

1998 • 4,047 citations

Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis

1993 • 2,711 citations

CpG island methylator phenotype in colorectal cancer

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Genetic instability in colorectal cancers

1997 • 1,989 citations

Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma

1998 • 1,852 citations

Tumor Microsatellite Instability and Clinical Outcome in Young Patients with Colorectal Cancer

2000 • 1,352 citations

Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon

1994 • 1,205 citations

Hypermethylation of the hMLH1 promoter in colon cancer with microsatellite instability.

1998 • 855 citations

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1994 • 807 citations

Aging and DNA methylation in colorectal mucosa and cancer.

1998 • 620 citations

Population-Based Molecular Detection of Hereditary Nonpolyposis Colorectal Cancer

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Genetic instability occurs in the majority of young patients with colorectal cancer

1995 • 378 citations

Microsatellite instability and the clinicopathological features of sporadic colorectal cancer

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Genetic and Epigenetic Modification of MLH1 Accounts for a Major Share of Microsatellite-Unstable Colorectal Cancers

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A Second Look

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Prognostic significance of extensive microsatellite instability in sporadic clinicopathological stage C colorectal cancer

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1991 • 202 citations

Environmental Exposure, DNA Methylation, and Gene Regulation

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1983 • 192 citations

Diet and DNA Methylation Interactions in Cancer Prevention

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1993 • 151 citations

Prognostic Significance of DNA Replication Errors in Young Patients With Colorectal Cancer

1998 • 124 citations

A national population-based study of incidence of colorectal cancer and age. Implications for screening in older Americans

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Prognostic significance of microsatellite instability determined by immunohistochemical staining of MSH2 and MLH1 in sporadic T3N0M0 colon cancer

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Continued change in the distribution of colorectal carcinoma

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Prognostic significance of microsatellite instability in sporadic colorectal cancer

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Rightward Shift of Colon Cancer

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Female gender is a major determinant of changing subsite distribution of colorectal cancer with age

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Changing site distribution patterns of colorectal cancer at Thomas Jefferson University Hospital

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1985 • 47 citations

Patient and tumor characteristics of colon cancers with microsatellite instability: a population-based study.

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Epidemiologic Considerations to Assess Altered DNA Methylation from Environmental Exposures in Cancer

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Microsatellite instability in early onset and familial colorectal cancer.

1996 • 40 citations

Varying features of early age-of-onset “Sporadic” and hereditary nonpolyposis colorectal cancer patients

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Stomach and Colorectal Cancers in Puerto Rican-Born Residents of New York City2

1986 • 32 citations

Increasing incidence of cecal and sigmoid carcinoma: Data from the connecticut tumor registry

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Distinct clinical features associated with microsatellite instability in colorectal cancers of young patients

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The Rightward Shift of Colon Cancer

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Characterization of Mutator Pathway in Younger-age-onset Colorectal Adenocarcinomas

2003 • 6 citations

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