Development and application of an enzyme-linked immunosorbent assay for the quantitation of alternative complement pathway activation in human serum.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Complement Activation during Cardiopulmonary Bypass

1981 • 1,163 citations

Hemodialysis leukopenia. Pulmonary vascular leukostasis resulting from complement activation by dialyzer cellophane membranes.

1977 • 1,004 citations

The Properdin System and Immunity: I. Demonstration and Isolation of a New Serum Protein, Properdin, and Its Role in Immune Phenomena

1954 • 940 citations

Human complement C3b inactivator: isolation, characterization, and demonstration of an absolute requirement for the serum protein beta1H for cleavage of C3b and C4b in solution.

1977 • 685 citations

ASSOCIATION OF COMPLEMENT ACTIVATION AND ELEVATED PLASMA-C5a WITH ADULT RESPIRATORY DISTRESS SYNDROME

1980 • 561 citations

Third component of human complement: purification from plasma and physicochemical characterization

1976 • 523 citations

Activation of the alternate pathway of human complements by rabbit cells.

1974 • 473 citations

Formation of the initial C3 convertase of the alternative complement pathway. Acquisition of C3b-like activities by spontaneous hydrolysis of the putative thioester in native C3.

1981 • 426 citations

Molecular Biology and Chemistry of the Alternative Pathway of Complement

1980 • 409 citations

Complement C3 convertase: Cell surface restriction of β1H control and generation of restriction on neuraminidase-treated cells

1978 • 344 citations

Purification and radiolabeling of human C1q.

1981 • 295 citations

INTERACTIONS OF THE COMPLEMENT SYSTEM WITH ENDOTOXIC LIPOPOLYSACCHARIDE: CONSUMPTION OF EACH OF THE SIX TERMINAL COMPLEMENT COMPONENTS

1968 • 286 citations

Activation of the alternative complement pathway due to resistance of zymosan-bound.

1977 • 283 citations

Experimental Immunochemistry.

1949 • 279 citations

The Complement Abnormalities of Lipodystrophy

1976 • 264 citations

Lysis of RNA tumor viruses by human serum: direct antibody-independent triggering of the classical complement pathway.

1976 • 247 citations

Activation of the Properdin Pathway of Complement in Patients with Gram-Negative Bacteremia

1975 • 235 citations

Alternative pathway of complement: recruitment of precursor properdin by the labile C3/C5 convertase and the potentiation of the pathway.

1976 • 204 citations

The Alternative Pathway C3/C5 Convertase: Chemical Basis of Factor B Activation

1979 • 201 citations

Initiation of the alternative pathway of complement: recognition of activators by bound C3b and assembly of the entire pathway from six isolated proteins.

1978 • 172 citations

Studies on the selective lysis and purification of Trypanosoma cruzi.

1975 • 159 citations

Serum Complement Levels in Bacteremia Due to Gram-Negative Organisms

1973 • 159 citations

Activation of the Alternative Complement Pathway by Pneumococcal Cell Wall Teichoic Acid

1978 • 157 citations

Role of Complement Activation in a Model of Adult Respiratory Distress Syndrome

1980 • 154 citations

A new role for C-1-inhibitor in homeostasis: control of activation of the first component of human complement.

1982 • 148 citations

Complement Depletion in Cryptococcal Sepsis

1978 • 124 citations

THE ROLE OF PROPERDIN IN THE ALTERNATE PATHWAY OF COMPLEMENT ACTIVATION

1974 • 118 citations

THE PROPERDIN SYSTEM AND IMMUNITY. IV. THE HEMOLYSIS OF ERYTHROCYTES FROM PATIENTS WITH PAROXYSMAL NOCTURNAL HEMOGLOBINURIA 1

1956 • 116 citations

Properdin- and nephritic factor-dependent C3 convertases: requirement of native C3 for enzyme formation and the function of bound C3b as properdin receptor.

1975 • 115 citations

Activation of the alternative complement pathway: recognition of surface structures on activators by bound C3b.

1980 • 103 citations

Activation of the Alternative Pathway of the Complement System by Radiographic Contrast Media

1976 • 102 citations

Glomerular and Dermal Deposition of Properdin in Systemic Lupus Erythematosus

1972 • 93 citations

Kinetic Assessment of Alternative Complement Pathway Activity in a Hemolytic System. I. Experimental and Mathematical Analyses

1978 • 83 citations

Cholesterol and atheroma lipids activate complement and stimulate granulocytes. A possible mechanism for amplification of ischemic injury in atherosclerotic states.

1981 • 82 citations

The role of C3 fragments in endocytosis and extracellular cytotoxic reactions by polymorphonuclear leukocytes

1982 • 70 citations

Neutralization of influenza virus by normal human sera: mechanisms involving antibody and complement.

1983 • 68 citations

THE PROPERDIN SYSTEM AND IMMUNITY

1956 • 67 citations

Raji cell injury and subsequent lysis by the purified cytolytic alternative pathway of human complement

1980 • 60 citations

Complement Activation In Bullous Skin Diseases

1975 • 60 citations

Initiation of C3 cleavage in the alternative complement pathway.

1975 • 58 citations

Metabolism of the fifth component of complement, and its relation to metabolism of the third component, in patients with complement activation.

1977 • 56 citations

Studies on chronic membranoproliferative glomerulonephritis with hypocomplementemia.

1971 • 55 citations

Activity of the alternative complement pathway after splenectomy: Comparison to activity in sickle cell disease and hypogammaglobulinemia

1979 • 53 citations

Isolation of Epstein Barr-virus and studies of its neutralization by human IgG and complement.

1981 • 52 citations

Initiation of C3 Cleavage in the Alternative Complement Pathway

1975 • 49 citations

Activation of the alternative complement pathway by enveloped viruses containing limited amounts of sialic acid

1981 • 48 citations

Kinetic Assessment of Alternative Complement Pathway Activity in A Hemolytic System

1978 • 46 citations

Native and activated properdin: interconvertibility and identity of amino- and carboxy-terminal sequences.

1980 • 44 citations

Complement activation in vitro induced by endotoxin and injured tissue

1979 • 43 citations

Serum Factors Activating the Alternative Complement Pathway in Autoimmune Disease: Description of Two Different Factors from Patients with Systemic Lupus Erythematosus

1976 • 43 citations

Multiple sedimenting species of properdin in human serum and interaction of purified properdin with the third component of complement.

1976 • 40 citations

Disorders of the complement system in lipodystrophy

1977 • 37 citations

Humoral Immunity to Viruses

1979 • 34 citations

Activation of Complement by Cells Infected with Respiratory Syncytial Virus

1981 • 33 citations

Metabolism of properdin in normal subjects and patients with renal disease.

1975 • 27 citations

Antibody-independent activation of the alternative complement pathway in human serum by parasitic cells.

1977 • 26 citations

Properdin levels in systemic lupus erythematosus and membranoproleferative glomerulonephritis.

1974 • 25 citations

Schistosoma mansoni: Activation of the alternative pathway of human complement by schistosomula

1980 • 25 citations

Etiology and Pathogenesis of Systemic Lupus Erythematosus

2016 • 24 citations

Reduction in Alternative Complement Pathway Mediated C3 Conversion following Burn Injury

1981 • 24 citations

Deficient Activity of the Alternative Pathway of Complement in β Thalassemia Major

1981 • 24 citations

Activation of the alternative complement pathway by Histoplasma capsulatum

1980 • 22 citations

Decreased opsonic and chemotactic activities in sera of postburn patients and partial opsonic restoration with properdin and properdin convertase

1978 • 19 citations

Activation of the Classic Complement Pathway in Patients with the C3 Nephritic Factor

1980 • 17 citations

Evaluation of alternative pathway and factor B haemolytic activities in patients with systemic lupus erythematosus: correlations with the alternative pathway regulatory proteins.

1980 • 12 citations

Role of complement activation in a model of adult respiratory distress syndrome

1981 • 10 citations

Reversible Activation of Proactivator (Factor B) of the Alternative Pathway Without Cleavage of the Molecule

1976 • 9 citations

Reduction in alternative complement pathway mediated C3 conversion following burn injury

1982 • 2 citations