The dynamics of myosin and actin in solution are compatible with the mechanical features of the cross-bridge hypothesis

Muscle Structure and Theories of Contraction

1957 • 3,392 citations

Proposed Mechanism of Force Generation in Striated Muscle

1971 • 2,256 citations

The Mechanism of Muscular Contraction

1969 • 1,928 citations

Changes in the Cross-Striations of Muscle during Contraction and Stretch and their Structural Interpretation

1954 • 1,655 citations

Structural Changes in Muscle During Contraction: Interference Microscopy of Living Muscle Fibres

1954 • 1,532 citations

Electron microscope studies on the structure of natural and synthetic protein filaments from striated muscle

1963 • 1,452 citations

Mechanism of adenosine triphosphate hydrolysis by actomyosin

1971 • 1,289 citations

Studies on the chymotryptic digestion of myosin. Effects of divalent cations on proteolytic susceptibility

1977 • 632 citations

Induced Changes in Orientation of the Cross-Bridges of Glycerinated Insect Flight Muscle

1965 • 471 citations

Shape and flexibility of the myosin molecule

1978 • 329 citations

A cross-bridge model of muscle contraction

1979 • 317 citations

Subunits in biological systems

1971 • 299 citations

Segmental flexibility of the S-1 moiety of myosin

1973 • 233 citations

OPTICAL ROTATION AND HELICAL POLYPEPTIDE CHAIN CONFIGURATION IN α-PROTEINS

1957 • 222 citations

Dynamic study of F-actin by quasielastic scattering of laser light

1971 • 175 citations

Rotational dynamics of spin-labeled F-actin in the sub-millisecond time range

1979 • 141 citations

Submillisecond rotational dynamics of spin-labeled myosin heads in myofibrils

1980 • 131 citations

Electronmicroscopic investigation of the flexibility of f-actin

1977 • 100 citations

Hinge region of myosin

1973 • 100 citations

Internal motions in myosin

1979 • 96 citations

X-ray Diffraction from Living Striated Muscle during Contraction

1965 • 95 citations

Isolation and physico-chemical properties of a high molecular weight subfragment-2 of myosin

1978 • 92 citations

Topography of the Myosin Molecule as Visualized by an Improved Negative Staining Method

1978 • 78 citations

Defining the “fast-reacting” thiols of myosin by reaction with 1,5 IAEDANS

1976 • 72 citations

Dynamics of F-actin and F-actin complexes

1974 • 71 citations

Cross-linking of myosin thick filaments under activating and rigor conditions. A study of the radial disposition of cross-bridges

1977 • 71 citations

The effects of temperature and salts on myosin subfragment-1 and F-actin association

1977 • 69 citations

Study of Actin and Its Interactions with Heavy Meromyosin and the Regulatory Proteins by the Pulse Fluorimetry in Polarized Light of a Fluorescent Probe Attached to an Actin Cysteine

1978 • 66 citations

The molecular dimensions and the monomer-dimer transformation of actin

1953 • 66 citations

A fluorimetric method for continuously assaying ATPase: Application to small specimens of glycerol-extracted muscle fibers

1979 • 59 citations

Fluorescence depolarization studies on the flexibility of myosin rod

1977 • 59 citations

Actin–actin bond strength and the conformational change of F-actin1

1977 • 59 citations

Diffusion coefficients for segmentally flexible macromolecules: General formalism and application to rotational behavior of a body with two segments

1980 • 54 citations

Anisotropy Decay of Labelled Actin

1979 • 52 citations

A general method for evaluation of diffusion constants, dilute‐solution viscoelasticity, and the dielectric property of a rigid macromolecule with an arbitrary configuration. I

1977 • 51 citations

The G-actin → F-actin transformation as studied by the fluorescence of bound dansyl cystine

1971 • 50 citations

Nanosecond pulsefluorometry in polarized light of G‐actin‐ϵ‐ATP and F‐actin‐ϵ‐ADP

1975 • 45 citations

Conformation of myosin in dilute solution as estimated from hydrodynamic properties

1980 • 45 citations

Transport properties of particles with segmental flexibility. II. Decay of fluorescence polarization anisotropy from hinged macromolecules

1980 • 41 citations

Electro-optical property of extremely stretched skinned muscle fibers

1975 • 36 citations

Fluctuations in tension during contraction of single muscle fibers

1977 • 35 citations

Binding of 1,N6-ethanoadenosine triphosphate to actin

1974 • 34 citations

Intrinsic segmental flexibility of the S-1 moiety of myosin using single-headed myosin

1978 • 33 citations

Thermal transitions of myosin and its helical fragments. Regions of structural instability in the myosin molecule

1976 • 33 citations

Cross-bridge movement in glycerinated rabbit psoas muscle fibers

1979 • 31 citations

Fluorescence study of N-(3-pyrene)maleimide conjugated to rabbit skeletal F-actin and plasmodium actin polymers

1976 • 29 citations

Infinite-Dilution Viscoelastic Properties of Myosin

1978 • 28 citations

Electric birefringence of myosin subfragments

1975 • 25 citations

G‐actin binding quenches internal motions in myosin subfragment‐1

1980 • 20 citations

Nanosecond pulse fluorometry in polarized light of dansyl‐L‐cysteine linked to a unique SH group of F‐actin; The influence of regulatory proteins and myosin moiety

1975 • 20 citations

Internal motions in myosin. 2

1981 • 19 citations

Birefringence changes in vertebrate striated muscle

1975 • 19 citations

Nanosecond fluorescence depolarization studies on actin labeled with 1,5‐IAEDANS and dansyl chloride

1978 • 15 citations

Structure and Function of the Two Heads of the Myosin Molecule

1976 • 13 citations

Segmental flexibility in the myosin molecule: Evidence from binding studies of myosin fragments with actin

1975 • 10 citations

A guide to the muscle papers

1975 • 9 citations

Electron-microscopic mapping of the hinge region of myosin

1976 • 5 citations