Endothelial Chemokines Destabilize L-selectin-mediated Lymphocyte Rolling without Inducing Selectin Shedding

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Leukocytes roll on a selectin at physiologic flow rates: Distinction from and prerequisite for adhesion through integrins

1991 • 2,195 citations

Selectins and their ligands: current concepts and controversies

1996 • 1,446 citations

Neutrophil Mac-1 and MEL-14 Adhesion Proteins Inversely Regulated by Chemotactic Factors

1989 • 1,135 citations

The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes

1997 • 1,124 citations

α4 integrins mediate lymphocyte attachment and rolling under physiologic flow

1995 • 1,018 citations

Chemokines and the Arrest of Lymphocytes Rolling Under Flow Conditions

1998 • 1,013 citations

Chemokines: immunology's high impact factors

2001 • 845 citations

Single-step separation of red blood cells, granulocytes and mononuclear leukocytes on discontinuous density gradients of Ficoll-Hypaque

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Transcytosis and Surface Presentation of IL-8 by Venular Endothelial Cells

1997 • 731 citations

Solution structure and basis for functional activity of stromal cell-derived factor-1; dissociation of CXCR4 activation from binding and inhibition of HIV-1

1997 • 724 citations

The α(1,3)Fucosyltransferase Fuc-TVII Controls Leukocyte Trafficking through an Essential Role in L-, E-, and P-selectin Ligand Biosynthesis

1996 • 723 citations

Lifetime of the P-selectin-carbohydrate bond and its response to tensile force in hydrodynamic flow

1995 • 705 citations

Insights into the Molecular Basis of Leukocyte Tethering and Rolling Revealed by Structures of P- and E-Selectin Bound to SLeX and PSGL-1

2000 • 704 citations

An endothelial ligand for L-Selectin is a novel mucin-like molecule

1992 • 660 citations

Chemokines in tissue-specific and microenvironment-specific lymphocyte homing

2000 • 643 citations

The neutrophil selectin LECAM-1 presents carbohydrate ligands to the vascular selectins ELAM-1 and GMP-140

1991 • 592 citations

Chemokines Trigger Immediate β2 Integrin Affinity and Mobility Changes

2000 • 517 citations

The chemokine SDF‐lα triggers CXCR4 receptor dimerization and activates the JAK/STAT pathway

1999 • 510 citations

Molecular Mechanisms of Lymphocyte Homing to Peripheral Lymph Nodes

1998 • 469 citations

Identification of a human peripheral lymph node homing receptor: a rapidly down-regulated adhesion molecule.

1990 • 447 citations

Chemotactic factors regulate lectin adhesion molecule 1 (LECAM-1)-dependent neutrophil adhesion to cytokine-stimulated endothelial cells in vitro.

1991 • 439 citations

The Cc Chemokine Thymus-Derived Chemotactic Agent 4 (Tca-4, Secondary Lymphoid Tissue Chemokine, 6ckine, Exodus-2) Triggers Lymphocyte Function–Associated Antigen 1–Mediated Arrest of Rolling T Lymphocytes in Peripheral Lymph Node High Endothelial Venules

2000 • 420 citations

A central role for microvillous receptor presentation in leukocyte adhesion under flow

1995 • 380 citations

The Kinetics of L-selectin Tethers and the Mechanics of Selectin-mediated Rolling

1997 • 355 citations

Characterization of the cell surface heterodimer VLA-4 and related peptides.

1987 • 340 citations

Subsecond Induction of α4 Integrin Clustering by Immobilized Chemokines Stimulates Leukocyte Tethering and Rolling on Endothelial Vascular Cell Adhesion Molecule 1 under Flow Conditions

2000 • 327 citations

The human peripheral lymph node vascular addressin is a ligand for LECAM-1, the peripheral lymph node homing receptor.

1991 • 307 citations

Neutrophil rolling altered by inhibition of L-selectin shedding in vitro

1996 • 285 citations

An Automatic Braking System That Stabilizes Leukocyte Rolling by an Increase in Selectin Bond Number with Shear

1999 • 229 citations

L-Selectin Shedding Regulates Leukocyte Recruitment

2001 • 221 citations

Metalloproteinase-mediated Regulation of L-selectin Levels on Leucocytes

1996 • 212 citations

Regulation of leukocyte rolling and adhesion to high endothelial venules through the cytoplasmic domain of L-selectin.

1993 • 206 citations

A Direct Comparison of Selectin-Mediated Transient, Adhesive Events Using High Temporal Resolution

1999 • 194 citations

The C–C Chemokine MCP-1 Differentially Modulates the Avidity of β1 and β2 Integrins on T Lymphocytes

1996 • 193 citations

Granulocyte-endothelium initial adhesion. Analysis of transient binding events mediated by E-selectin in a laminar shear flow

1993 • 190 citations

GlyCAM-1, a physiologic ligand for L-selectin, activates beta 2 integrins on naive peripheral lymphocytes.

1996 • 184 citations

The cytoplasmic domain of L-selectin interacts with cytoskeletal proteins via alpha-actinin: receptor positioning in microvilli does not require interaction with alpha-actinin.

1995 • 177 citations

Sulfation of L-Selectin Ligands by an HEV-Restricted Sulfotransferase Regulates Lymphocyte Homing to Lymph Nodes

2001 • 161 citations

CCR5, CXCR4, and CD4 Are Clustered and Closely Apposed on Microvilli of Human Macrophages and T Cells

2001 • 157 citations

Relevance of L-selectin Shedding for Leukocyte Rolling In Vivo

1999 • 149 citations

Ligation of L-selectin through conserved regions within the lectin domain activates signal transduction pathways and integrin function in human, mouse, and rat leukocytes.

1997 • 137 citations

Dimerization of a selectin and its ligand stabilizes cell rolling and enhances tether strength in shear flow

2001 • 126 citations

Reconstitution of functional L-selectin ligands on a cultured human endothelial cell line by cotransfection of α1→3 fucosyltransferase VII and newly cloned GlcNAcβ:6-sulfotransferase cDNA

1999 • 120 citations

Negative Regulation of T Cell Homing by CD43

1998 • 117 citations

Leukocyte activation induces surface redistribution of P-selectin glycoprotein ligand-1

1997 • 115 citations

Recombinant NeutraLite Avidin: a non‐glycosylated, acidic mutant of chicken avidin that exhibits high affinity for biotin and low non‐specific binding properties

2000 • 107 citations

Signaling Functions of L-Selectin in Neutrophils: Alterations in the Cytoskeleton and Colocalization with CD18

1999 • 103 citations

Cytoplasmic anchorage of L-selectin controls leukocyte capture and rolling by increasing the mechanical stability of the selectin tether

2001 • 102 citations

EBI1-ligand chemokine (ELC) attracts a broad spectrum of lymphocytes: activated T cells strongly up-regulate CCR7 and efficiently migrate toward ELC

1998 • 100 citations

The faster kinetics of L-selectin than of E-selectin and P-selectin rolling at comparable binding strength.

1997 • 91 citations

Autocrine Secretion of Interferon γ Negatively Regulates Homing of Immature B Cells

2000 • 85 citations

A differential role for cell shape in neutrophil tethering and rolling on endothelial selectins under flow.

1996 • 82 citations

Regulation of L-Selectin–mediated Rolling through Receptor Dimerization

1998 • 66 citations

Interactions of the Cytoplasmic Domain of P-Selectin with Clathrin-coated Pits Enhance Leukocyte Adhesion under Flow

1998 • 53 citations

Chemoattractant Receptor-induced Phosphorylation of L-selectin

1997 • 49 citations

An Activated L-selectin Mutant with Conserved Equilibrium Binding Properties but Enhanced Ligand Recognition under Shear Flow

2000 • 45 citations

Effects of selective protein kinase C inhibitors on the proteolytic down-regulation of L-selectin from chemoattractant-activated neutrophils

2000 • 45 citations

GIyCAM-1 supports leukocyte rolling in flow: Evidence for a greater dynamic stability of L-selectin rolling of lymphocytes than of neutrophils

1998 • 28 citations