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Management of Secondary Hyperparathyroidism: The Importance and the Challenge of Controlling Parathyroid Hormone Levels without Elevating Calcium, Phosphorus, and Calcium-Phosphorus Product

Data up to Jan 2025

Published2003
Citations146
References129

Total Citations Per Year

Abstract

References (129)

K/DOQI clinical practice guidelines for bone metabolism and disease in chronic kidney disease

2003 • 2,466 citations

Coronary-Artery Calcification in Young Adults with End-Stage Renal Disease Who Are Undergoing Dialysis

2000 • 2,426 citations

Association of serum phosphorus and calcium x phosphate product with mortality risk in chronic hemodialysis patients: A national study

1998 • 2,334 citations

CORONARY-ARTERY CALCIFICATION IN YOUNG ADULTS WITH END-STAGE RENAL DISEASE WHO ARE UNDERGOING DIALYSIS

2000 • 2,241 citations

Impact of Aortic Stiffness on Survival in End-Stage Renal Disease

1999 • 2,131 citations

The Dialysis Encephalopathy Syndrome

1976 • 1,636 citations

Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling

1992 • 1,514 citations

Sevelamer attenuates the progression of coronary and aortic calcification in hemodialysis patients

2002 • 1,452 citations

Arterial Calcifications, Arterial Stiffness, and Cardiovascular Risk in End-Stage Renal Disease

2001 • 1,391 citations

Association of Elevated Serum PO4, Ca × PO4 Product, and Parathyroid Hormone with Cardiac Mortality Risk in Chronic Hemodialysis Patients

2001 • 1,198 citations

Cardiac calcification in adult hemodialysis patients

2002 • 1,084 citations

Bone morphogenetic protein expression in human atherosclerotic lesions.

1993 • 1,014 citations

Arterial stiffening and vascular calcifications in end‐stage renal disease

2000 • 991 citations

Atherosclerotic cardiovascular disease risks in chronic hemodialysis patients

2000 • 765 citations

The spectrum of bone disease in end-stage renal failure—An evolving disorder

1993 • 737 citations

Extracellular Ca2+ sensing, regulation of parathyroid cell function, and role of Ca2+ and other ions as extracellular (first) messengers

1991 • 690 citations

High expression of genes for calcification-regulating proteins in human atherosclerotic plaques.

1994 • 616 citations

Re-evaluation of risks associated with hyperphosphatemia and hyperparathyroidism in dialysis patients: Recommendations for a change in management

2000 • 598 citations

Increased incidence of hip fractures in dialysis patients with low serum parathyroid hormone

2000 • 587 citations

Regulation by vitamin D metabolites of parathyroid hormone gene transcription in vivo in the rat.

1986 • 530 citations

Phosphorus restriction prevents parathyroid gland growth. High phosphorus directly stimulates PTH secretion in vitro.

1996 • 512 citations

Medial artery calcification in ESRD patients is associated with deposition of bone matrix proteins

2002 • 451 citations

Parathyroid cell proliferation in normal and chronic renal failure rats. The effects of calcium, phosphate, and vitamin D.

1995 • 407 citations

Calcium Carbonate as a Phosphate Binder in Patients with Chronic Renal Failure Undergoing Dialysis

1986 • 389 citations

Paricalcitol versus calcitriol in the treatment of secondary hyperparathyroidism

2003 • 378 citations

FRACTURING DIALYSIS OSTEODYSTROPHY AND DIALYSIS ENCEPHALOPATHY

1979 • 374 citations

Nocturnal hemodialysis

1998 • 365 citations

SYNDROME OF DYSPRAXIA AND MULTIFOCAL SEIZURES ASSOCIATED WITH CHRONIC HEMODIALYSIS

1972 • 359 citations

Diffuse calcification in human coronary arteries. Association of osteopontin with atherosclerosis.

1994 • 357 citations

19-Nor-1-alpha-25-dihydroxyvitamin D2 (Paricalcitol) safely and effectively reduces the levels of intact parathyroid hormone in patients on hemodialysis.

1998 • 340 citations

Evidence for abnormal calcium homeostasis in patients with adynamic bone disease

1994 • 330 citations

Risk factors for vertebral fractures in renal osteodystrophy

1999 • 324 citations

Intravenous Calcitriol in the Treatment of Refractory Osteitis Fibrosa of Chronic Renal Failure

1989 • 324 citations

A multicenter study on the effects of lanthanum carbonate (Fosrenol™) and calcium carbonate on renal bone disease in dialysis patients

2003 • 322 citations

Development of adynamic bone in patients with secondary hyperparathyroidism after intermittent calcitriol therapy

1994 • 316 citations

Bone mineral density and biochemical markers of bone turnover in patients with predialysis chronic renal failure

1999 • 301 citations

RenaGel®, a nonabsorbed calcium- and aluminum-free phosphate binder, lowers serum phosphorus and parathyroid hormone

1999 • 300 citations

Aplastic osteodystrophy without aluminum: The role of “suppressed” parathyroid function

1993 • 288 citations

A comparison of the calcium-free phosphate binder sevelamer hydrochloride with calcium acetate in the treatment of hyperphosphatemia in hemodialysis patients

1999 • 279 citations

Calcification of Human Vascular Cells In Vitro Is Correlated With High Levels of Matrix Gla Protein and Low Levels of Osteopontin Expression

1998 • 264 citations

Action of 1,25-Dihydroxycholecalciferol, a Potent, Kidney-Produced Metabolite of Vitamin D3, in Uremic Man

1972 • 260 citations

Prospective trial of pulse oral versus intravenous calcitriol treatment of hyperparathyroidism in ESRD

1994 • 255 citations

The Calcimimetic AMG 073 as a Potential Treatment for Secondary Hyperparathyroidism of End-Stage Renal Disease

2003 • 254 citations

Poly[allylamine hydrochloride] (RenaGel): A noncalcemic phosphate binder for the treatment of hyperphosphatemia in chronic renal failure

1997 • 250 citations

Hyperphosphatemia: Its Consequences and Treatment in Patients With Chronic Renal Disease

1992 • 242 citations

Reduction of dietary phosphorus absorption by phosphorus binders. A theoretical, in vitro, and in vivo study.

1989 • 241 citations

Composition of the domestic water supply and the incidence of fractures and encephalopathy in patients on home dialysis.

1977 • 241 citations

The noncalcemic analogue of vitamin D, 22-oxacalcitriol, suppresses parathyroid hormone synthesis and secretion.

1989 • 237 citations

The calcimimetic AMG 073 reduces parathyroid hormone and calcium x phosphorus in secondary hyperparathyroidism

2003 • 235 citations

Cardiovascular Mortality in End-Stage Renal Disease

2003 • 232 citations

The role of phosphorus restriction in the prevention of secondary hyperparathyroidism in chronic renal disease

1973 • 230 citations

Calciphylaxis is associated with hyperphosphatemia and increased osteopontin expression by vascular smooth muscle cells

2001 • 226 citations

Arterial structure and function in end-stage renal disease

2002 • 223 citations

Cardiovascular disease in patients with chronic kidney disease: Getting to the heart of the matter

2001 • 222 citations

An Epidemiological Survey

1950 • 219 citations

Biochemical markers of renal osteodystrophy in pediatric patients undergoing CAPD/CCPD

1994 • 211 citations

Management of disturbances of calcium and phosphate metabolism in chronic renal insufficiency, with emphasis on the control of hyperphosphataemia

2002 • 205 citations

Control of phosphate excretion in uremic man

1968 • 200 citations

Influence of Biochemical Alterations on Arterial Stiffness in Patients With End-stage Renal Disease

1998 • 196 citations

High phosphate level directly stimulates parathyroid hormone secretion and synthesis by human parathyroid tissue in vitro.

1998 • 189 citations

5'-flanking region of the parathyroid hormone gene mediates negative regulation by 1,25-(OH)2 vitamin D3.

1988 • 165 citations

Decreased calcium-sensing receptor expression in hyperplastic parathyroid glands of uremic rats: Role of dietary phosphate

1999 • 162 citations

Inhibition of rat vascular smooth muscle proliferation in vitro and in vivo by bone morphogenetic protein-2.

1997 • 160 citations

Pathogenesis of Secondary Hyperparathyroidism

1994 • 147 citations

Calcium acetate, an effective phosphorus binder in patients with renal failure

1989 • 146 citations

Effective suppression of parathyroid hormone by 1α-hydroxy-vitamin D2 in hemodialysis patients with moderate to severe secondary hyperparathyroidism

1997 • 137 citations

Calcimimetic NPS R-568 prevents parathyroid hyperplasia in rats with severe secondary hyperparathyroidism

2000 • 134 citations

Cardiovascular calcification in patients with end-stage renal disease: A century-old phenomenon

2002 • 129 citations

Paricalcitol in dialysis patients with calcitriol-resistant secondary hyperparathyroidism

2001 • 129 citations

A randomized trial of sevelamer hydrochloride (RenaGel) with and without supplemental calcium. Strategies for the control of hyperphosphatemia and hyperparathyroidism in hemodialysis patients.

1999 • 126 citations

Association of hyperphosphataemia with haemodynamic disturbances in end-stage renal disease

1999 • 115 citations

Effect of RenaGel(R), a non-absorbed, calcium- and aluminium-free phosphate binder, on serum phosphorus, calcium, and intact parathyroid hormone in end-stage renal disease patients

1998 • 110 citations

Efficacy and side effects of intermittent intravenous and oral doxercalciferol (1alpha-hydroxyvitamin D(2)) in dialysis patients with secondary hyperparathyroidism: a sequential comparison.

2001 • 110 citations

The effect of long-term intravenous calcitriol administration on parathyroid function in hemodialysis patients.

1991 • 105 citations

Vitamin D analogues for secondary hyperparathyroidism

2002 • 103 citations

The natural course of dialysis osteomalacia.

1986 • 103 citations

Suppression of parathyroid hormone secretion in hemodialysis patients: Comparison of paricalcitol with calcitriol

2001 • 101 citations

Hemodiafiltration--a new treatment option for hyperphosphatemia in hemodialysis patients.

1999 • 98 citations

Calcium Acetate Control of Serum Phosphorus in Hemodialysis Patients

1991 • 96 citations

The Noncalcemic Analogue of Vitamin D, 22-Oxacalcitriol, Suppresses Parathyroid Hormone Synthesis and Secretion

2015 • 95 citations

1-ALPHA-HYDROXYCHOLECALCIFEROL AS A SUBSTITUTE FOR THE KIDNEY HORMONE 1,25-DIHYDROXYCHOLECALCIFEROL IN CHRONIC RENAL FAILURE

1973 • 93 citations

Factors associated with calcification of the abdominal aorta in hemodialysis patients

1999 • 93 citations

Magnesium carbonate as a phosphorus binder: A prospective, controlled, crossover study

1996 • 87 citations

Renal bone disease in pediatric and young adult patients on hemodialysis in a children's hospital.

1993 • 83 citations

Human parathyroid cell proliferation in response to calcium, NPS R‐467, calcitriol and phosphate

2001 • 80 citations

Influence of calcium acetate or calcium citrate on intestinal aluminum absorption

1990 • 71 citations

Stabilized polynuclear iron hydroxide is an efficient oral phosphate binder in uraemic patients

1999 • 68 citations

The Effects of Calcium, Phosphate, and Vitamin D

1995 • 67 citations

Pharmacological Regulation of Parathyroid Hormone Secretion

2002 • 67 citations

New Phosphate Binding Agents

1999 • 64 citations

Update on vitamin D and its newer analogues: Actions and rationale for treatment in chronic renal failure

2002 • 63 citations

Negative regulatory elements in the human parathyroid hormone gene.

1991 • 60 citations

Aluminum and Renal Osteodystrophy

1986 • 60 citations

An open‐label, crossover study of a new phosphate‐binding agent in haemodialysis patients: ferric citrate

2002 • 60 citations

High prevalence of adynamic bone disease diagnosed by biochemical markers in a wide sample of the European CAPD population

1997 • 57 citations

Calcium acetate as a phosphorus binder in hemodialysis patients.

1992 • 56 citations

22-Oxacalcitriol suppresses secondary hyperparathyroidism without inducing low bone turnover in dogs with renal failure

1999 • 54 citations

Strategies to minimize bone disease in renal failure

2001 • 51 citations

Cardiac Disease in Chronic Uremia: Epidemiology

1997 • 49 citations

Paricalcitol dosing according to body weight or severity of hyperparathyroidism: A double-blind, multicenter, randomized study

2001 • 49 citations

New analogs of vitamin D3

1999 • 48 citations

Vascular calcification in the uremic patient: A cardiovascular risk?

2003 • 47 citations

Hyperphosphataemia as a cardiovascular risk factor - how to manage the problem

2002 • 44 citations

The relationship between serum calcium and phosphate levels and cardiac valvular procedures in the hemodialysis population

2003 • 43 citations

Renal osteodystrophy and secondary hyperparathyroidism

2002 • 42 citations

Calcium carbonate (CaCO3): an efficient and safe phosphate binder in haemodialysis patients? A 3-year study

1993 • 40 citations

Evidence that parathyroid hormone is not required for phosphate homeostasis in renal failure

1975 • 40 citations

Renal handling of calcium, magnesium and inorganic phosphate in chronic renal failure.

1967 • 40 citations

Parathyroidectomy in Chronic Renal Failure: Has Medical Care Reduced the Need for Surgery?

2001 • 39 citations

Subtotal Parathyroidectomy in Renal Failure: Still Needed after All These Years

2001 • 37 citations

Dialysis encephalopathy: precipitating factors and improvement in prognosis.

1981 • 36 citations

Pathophysiology of renal osteodystrophy

2000 • 33 citations

A Theoretical, In Vitro, and In Vivo Study

1989 • 29 citations

Analysis of renal bone disease treatment in dialysis patients

2002 • 27 citations

Drug and hormone effects on calcium release from bone

1983 • 26 citations

Parathyroid hormone‐independent osteoclastic resorptive bone disease: a new variant of adynamic bone disease in haemodialysis patients

2002 • 25 citations

Suppressive effect of calcium on parathyroid hormone release in adynamic renal osteodystrophy and secondary hyperparathyroidism

1997 • 24 citations

Reduction of dietary phosphorus absorption by phosphorus binders. A theoretical in vitro and in vivo study by MS Sheikh, JA Maguire, M Emmett, CA Santa Ana, MJ Nicar, LR Schiller, and JS Fordtran.

1989 • 23 citations

A possible non-aluminum oral phosphate binder? A comparative study on dietary phosphorus absorption.

1995 • 22 citations

Imaging of cardiovascular calcifications with electron beam tomography in hemodialysis patients

2001 • 21 citations

Evolution of serum phosphate in long intermittent hemodialysis

2003 • 19 citations

Current Issues in the Management of Secondary Hyperparathyroidism and Bone Disease

2001 • 16 citations

Alternative phosphate binders in dialysis patients: calcium carbonate.

1986 • 16 citations

Calcium Balance in Chronic Renal Failure<subtitle>A STUDY USING <italic>in vivo</italic> NEUTRON ACTIVATION ANALYSIS</subtitle>

1973 • 14 citations

Calcium acetate versus calcium carbonate in the control of hyperphosphatemia in hemodialysis patients

2000 • 14 citations

Control of Hyperphosphatemia in Renal Failure: Role of Aluminum

1996 • 13 citations

Calcium Acetate, an Effective Phosphorus Binder in Patients with Renal Failure MARTIN L. MAI, MICHAEL EMMETT, MUDASSIR S. SHEIKH, CAROL A. SANTA ANA, LAWRENCE SCHILLER, JOHN S. FORDTRAN Baylor University Medical Center, Dallas, TX

1991 • 11 citations

Calcium ketovaline as new therapy for uremic hyperphosphatemia.

1990 • 9 citations

Calcium salts of keto-amino acids, a phosphate binder alternative for patients on CAPD.

1997 • 7 citations

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