Growth Retardation, Duodenal Lesions, and Aberrant Ileum Architecture in Triple Null Mice Lacking EGF, Amphiregulin, and TGF-α

Clinicopathologic study of dextran sulfate sodium experimental acute colitis

1998 • 1,955 citations

Targeted Disruption of Mouse EGF receptor: Effect of Genetic Background on Mutant Phenotype

1995 • 1,457 citations

Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor

1995 • 1,035 citations

Strain-Dependent Epithelial Defects in Mice Lacking the EGF Receptor

1995 • 1,016 citations

Specificity within the EGF family/ErbB receptor family signaling network

1998 • 804 citations

Overexpression of TGFα in transgenic mice: Induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast

1990 • 753 citations

TGFα deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice

1993 • 659 citations

Structure and Function of Human Amphiregulin: A Member of the Epidermal Growth Factor Family

1989 • 586 citations

Mice with a null mutation of the TGFα gene have abnormal skin architecture, wavy hair, and curly whiskers and often develop corneal inflammation

1993 • 578 citations

Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development

1999 • 551 citations

The mouse waved-2 phenotype results from a point mutation in the EGF receptor tyrosine kinase.

1994 • 441 citations

Differential susceptibility of inbred mouse strains to dextran sulfate sodium-induced colitis

1998 • 389 citations

Epidermal growth factor-related peptides and their relevance to gastrointestinal pathophysiology

1995 • 329 citations

Epidermal Growth Factor Is a Major Growth-Promoting Agent in Human Milk

1980 • 315 citations

Epidermal Growth Factor-related Peptides Activate Distinct Subsets of ErbB Receptors and Differ in Their Biological Activities

1996 • 311 citations

Identification and characterization of rat intestinal trefoil factor: tissue- and cell-specific member of the trefoil protein family.

1991 • 272 citations

Differentiation and self-renewal in the mouse gastrointestinal epithelium

1994 • 256 citations

Epidermal growth factor and transforming growth factor-alpha: differential intracellular routing and processing of ligand-receptor complexes.

1991 • 247 citations

Development of the newborn GI tract and its relation to colostrum/milk intake: a review

1996 • 219 citations

Gastrointestinal mucosal regeneration role of growth factors

1999 • 210 citations

Coordinated localisation of mucins and trefoil peptides in the ulcer associated cell lineage and the gastrointestinal mucosa

2000 • 190 citations

Dynamic expression and activation of ERBB receptors in the developing mouse mammary gland.

1998 • 166 citations

Transforming growth factor alpha: expression, regulation, and biological activities.

1995 • 166 citations

The trefoil gene family are coordinately expressed immediate-early genes: EGF receptor– and MAP kinase–dependent interregulation

1999 • 151 citations

Enhancement of intestinal growth in neonatal rats by epidermal growth factor in milk

1987 • 128 citations

Mice lacking transforming growth factor alpha have an increased susceptibility to dextran sulfate-induced colitis

1997 • 127 citations

Transforming growth factor alpha protection against drug-induced injury to the rat gastric mucosa in vivo.

1992 • 107 citations

Epidermal Growth Factor Inhibits Cysteamine-Induced Duodenal Ulcers

1983 • 100 citations

A Defective EGF-Receptor inWaved-2Mice Attenuates Intestinal Adaptation

1997 • 98 citations

Coordinate expression of lactase-phlorizin hydrolase mRNA and enzyme levels in rat intestine during development.

1990 • 96 citations

Mechanisms of regulatory peptide action in the gastrointestinal tract: trefoil peptides.

2000 • 91 citations

Nonmitogenic actions of growth factors: an integrated view of their role in intestinal physiology and pathophysiology.

1997 • 87 citations

Mice Harboring a Defective Epidermal Growth Factor Receptor-(Waved-2) Have an Increased Susceptibility to Acute Dextran-Sulfate-induced Colitis

2000 • 59 citations

Expression of sucrase-isomaltase mRNA along the villus-crypt axis in the rat small intestine.

1992 • 55 citations

Expression of Human Intestinal mRNA Transcripts during Development: Analysis by a Semiquantitative RNA Polymerase Chain Reaction Method

1994 • 51 citations

Temporal expression of trefoil peptides in the TGF-alpha knockout mouse after gastric ulceration

1997 • 45 citations

A comparison of in vivo cell proliferation measurements in the intestine of mouse and man.

1992 • 39 citations

Ontogeny of EGF Receptors During Postnatal Development of Mouse Small Intestine

1987 • 32 citations

Role of Epidermal Growth Factor in Gastroduodenal Mucosal Protection

1988 • 28 citations

Epidermal Growth Factor Receptors during Postnatal Development of the Mouse Colon*

1987 • 26 citations

Absorption of epidermal growth factor occurs through the gastrointestinal tract and oral cavity in adult rats

1995 • 26 citations

Inhibition of epidermal growth factor receptor tyrosine kinase fails to suppress adenoma formation in ApcMin mice but induces duodenal injury.

2000 • 17 citations

Ontogenic regulation of phospholipase C-γ1 activity and expression in the rat small intestine

1994 • 16 citations

The Rat Intrinsic Factor Gene: Its 5′-Upstream Region and Chief Cell-Specific Transcription1

1995 • 15 citations

Lessons from genetically engineered animal models X. Trefoil peptide and EGF receptor/ligand transgenic mice.

2000 • 9 citations