Enhancement of moxidectin bioavailability in lamb by a natural flavonoid: quercetin

Pharmacokinetics

1982 • 3,815 citations

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

1994 • 2,255 citations

Flavonoids: A class of modulators with bifunctional interactions at vicinal ATP- and steroid-binding sites on mouse P-glycoprotein

1998 • 376 citations

Ivermectin resistance in nematodes may be caused by alteration of P-glycoprotein homolog1Note: Nucleotide sequence data reported in this paper have been submitted to the GenBank data base with the accession number AF 003908.1

1998 • 290 citations

Avermectins: novel insecticides, acaricides and nematicides from a soil microorganism

1981 • 254 citations

A method for the simultaneous evaluation of the activities of seven major human drug-metabolizing cytochrome P450s using an in vitro cocktail of probe substrates and fast gradient liquid chromatography tandem mass spectrometry.

2001 • 232 citations

Avermectins. Structure determination

1981 • 229 citations

Reversal of P-glycoprotein-associated multidrug resistance by ivermectin

1997 • 174 citations

Lactic Dehydrogenase

1965 • 141 citations

Effects of intestinal CYP3A4 and P-glycoprotein on oral drug absorption--theoretical approach.

1999 • 126 citations

Identification of cytochrome P4503A4 as the major enzyme responsible for the metabolism of ivermectin by human liver microsomes

1998 • 114 citations

Milbemycins, a new family of macrolide antibiotics. Structure determination of milbemycins D,E,F,G,H,J and K.

1983 • 105 citations

Intestinal Secretion Is a Major Route for Parent Ivermectin Elimination in the Rat

2002 • 104 citations

Effects of the multidrug-resistance-reversing agents verapamil and CL 347,099 on the efficacy of ivermectin or moxidectin against unselected and drug-selected strains of Haemonchus contortus in jirds ( Meriones unguiculatus )

1999 • 104 citations

Haemonchus contortus: Sequence Heterogeneity of Internucleotide Binding Domains from P-Glycoproteinsand an Association with Avermectin/Milbemycin Resistance

1999 • 102 citations

Determination of moxidectin in plasma by high-performance liquid chromatography with automated solid-phase extraction and fluorescence detection

1995 • 92 citations

Absorption, Tissue Distribution, Metabolism, and Excretion of Moxidectin in Cattle

1994 • 90 citations

Ketoconazole Effectively Reverses Multidrug Resistance in Highly Resistant KB Cells

1994 • 85 citations

N-Deacetyl ketoconazole-induced hepatotoxicity in a primary culture system of rat hepatocytes

1997 • 83 citations

Effects of flavonols on P-glycoprotein activity in cultured rat hepatocytes

1995 • 77 citations

The effect of level of feed intake on the pharmacokinetic disposition and efficacy of ivermectin in sheep

1996 • 72 citations

Moxidectin in cattle: correlation between plasma and target tissues disposition

1999 • 69 citations

ChemInform Abstract: AVERMECTINS. STRUCTURE DETERMINATION

1981 • 60 citations

Effects of ketoconazole on the intestinal metabolism, transport and oral bioavailability of K02, a novel vinylsulfone peptidomimetic cysteine protease inhibitor and a P450 3A, P-glycoprotein dual substrate, in male Sprague-Dawley rats.

1998 • 59 citations

Loperamide‐induced enhancement of moxidectin availability in cattle

2002 • 49 citations

The behaviour of doramectin in the gastrointestinal tract, its secretion in bile and pharmacokinetic disposition in the peripheral circulation after oral and intravenous administration to sheep

2000 • 46 citations

Role of Cytochrome P450 Isoforms in the Metabolism of Abamectin and Ivermectin in Rats

1996 • 41 citations

Moxidectin: Absorption, Tissue Distribution, Excretion, and Biotransformation of 14C-Labeled Moxidectin in Sheep

1994 • 41 citations

Enhanced absorption of pour-on ivermectin formulation in rats by co-administration of the multidrug-resistant-reversing agent verapamil

1999 • 38 citations

Inhibitors of mdr1-dependent transport activity delay accumulation of the mdr1 substrate rhodamine 123 in primary rat hepatocyte cultures

2001 • 31 citations

In vitro metabolism of 14C-moxidectin by hepatic microsomes from various species.

2001 • 29 citations

Influence of verapamil on the efflux and metabolism of ¹⁴C moxidectin in cultured rat hepatocytes

2001 • 22 citations

Enhanced plasma availability of moxidectin in fasted horses

2000 • 18 citations

Moxidectin: Characterization of Cattle, Sheep, and Rat in vitro and in vivo Metabolites by Liquid Chromatography/Tandem Mass Spectrometry

1994 • 17 citations