Spin‐exchange NMR spectroscopy in studies of the kinetics of enzymes and membrane transport

The Advanced Theory of Statistics.

1978 • 6,960 citations

The Fourier Transform and Its Applications

1965 • 5,607 citations

Investigation of exchange processes by two-dimensional NMR spectroscopy

1979 • 4,720 citations

Red Cell Metabolism: A Manual of Biochemical Methods.

1971 • 2,377 citations

Reaction Rates by Nuclear Magnetic Resonance

1958 • 1,561 citations

Elucidation of cross relaxation in liquids by two-dimensional N.M.R. spectroscopy

1980 • 1,490 citations

The Fourier Transform and its Applications

1965 • 1,223 citations

Study of Moderately Rapid Chemical Exchange Reactions by Means of Nuclear Magnetic Double Resonance

1963 • 1,199 citations

Two-dimensional chemical exchange and cross-relaxation spectroscopy of coupled nuclear spins

1981 • 754 citations

Observation of tissue metabolites using 31P nuclear magnetic resonance

1974 • 616 citations

The Advanced Theory of Statistics.

1944 • 464 citations

A theoretical study of distance determinations from NMR. Two-dimensional nuclear overhauser effect spectra

1984 • 445 citations

Biological Applications of Magnetic Resonance

1979 • 437 citations

Nuclear magnetic resonance and its applications to living systems

1982 • 384 citations

Nmr studies of the rates of proline cis–trans isomerization in oligopeptides

1981 • 368 citations

Selective excitation in Fourier transform nuclear magnetic resonance

1978 • 367 citations

Nuclear magnetic resonance and its applications to living systems

1983 • 357 citations

Direct determination of rate constants of slow dynamic processes by two-dimensional "accordion" spectroscopy in nuclear magnetic resonance

1982 • 293 citations

Reaction rates of creatine kinase and ATP synthesis in the isolated rat heart. A 31P NMR magnetization transfer study.

1985 • 286 citations

Exchange Rates by Nuclear Magnetic Multiple Resonance. III. Exchange Reactions in Systems with Several Nonequivalent Sites

1964 • 259 citations

Nuclear Transfer Effects in Nuclear Magnetic Resonance Pulse Experiments

1961 • 229 citations

Fourier transform NMR spectroscopy

1977 • 216 citations

NMR Studies of Tissue Metabolism

1981 • 212 citations

³¹P NMR saturation transfer measurements of the steady state rates of creatine kinase and ATP synthetase in the rat brain

1982 • 203 citations

NMR studies of enzymatic ratesin vitroandin vivoby magnetization transfer

1984 • 201 citations

Two-dimensional NMR exchange spectroscopy. Quantitative treatment of multisite exchanging systems

1986 • 177 citations

A 31P-NMR saturation transfer study of the regulation of creatine kinase in the rat heart

1982 • 164 citations

NMR Spectroscopy — An Introduction

1981 • 151 citations

31P nuclear magnetic resonance measurements of ATPase kinetics in aerobic Escherichia coli cells.

1977 • 150 citations

Accounting for spin diffusion in the analysis of 2D NOE data

1986 • 149 citations

The accordion experiment, a simple approach to three-dimensional NMR spectroscopy

1981 • 145 citations

A New Method for the Study of Moderately Rapid Chemical Exchange Rates Employing Nuclear Magnetic Double Resonance.

1963 • 133 citations

The steady-state rate of ATP synthesis in the perfused rat heart measured by 31P NMR saturation transfer

1981 • 130 citations

Fourier transform NMR pulse methods for the measurement of slow-exchange rates

1978 • 128 citations

Multisite kinetics by quantitative two-dimensional NMR

1984 • 126 citations

APPLICATIONS OF NMR TO STUDIES OF TISSUE METABOLISM

1986 • 108 citations

A 31P-nuclear magnetic resonance study of skeletal muscle metabolism in rats depleted of creatine with the analogue β-guanidinopropionic acid

1984 • 106 citations

The applicability of the magnetization-transfer NMR technique to determine chemical exchange rates in extreme cases. The importance of complementary experiments

1982 • 103 citations

Pulsed NMR methods for the observation and assignment of exchangeable hydrogens: Application to bacitracin

1974 • 101 citations

In vivo flux between phosphocreatine and adenosine triphosphate determined by two-dimensional phosphorous NMR.

1983 • 97 citations

Kinetics of creatine kinase in heart: a phosphorus-31 NMR saturation- and inversion-transfer study

1985 • 90 citations

Double Nuclear Magnetic Resonance Observation of Electron Exchange between Ferri- and Ferrocytochrome c

1970 • 88 citations

Magnetization-transfer measurements of individual rate constants in the presence of multiple reactions

1985 • 82 citations

Water transport red blood cell membranes

1988 • 80 citations

³¹P magnetization transfer studies of creatine kinase kinetics in living rabbit brain

1987 • 74 citations

31P nuclear magnetic resonance kinetic measurements on adenylatekinase.

1977 • 67 citations

Fourier transform proton NMR in H2O. A method for measuring exchange and relaxation rates

1977 • 67 citations

Quantitative 2D exchange spectroscopy using time-proportional phase incrementation

1986 • 64 citations

Skewed exchange spectroscopy. Two-dimensional method for the measurement of cross relaxation in proton NMR spectroscopy

1984 • 63 citations

In vivo phosphorus-31 NMR saturation transfer studies of ATPase kinetics in Saccharomyces cerevisiae

1982 • 62 citations

Measurement of Mitochondrial ATPase Activity in Maize Root Tips by Saturation Transfer ³¹P Nuclear Magnetic Resonance

1984 • 61 citations

Proton magnetic double-resonance study of angiotensin II (Asn¹Val⁵) in aqueous solution employing correlation spectroscopy. Assignment of peptide NH resonances and transfer of saturation from water.

1974 • 61 citations

A simple procedure for selective inversion of NMR resonances for spin transfer enzyme kinetic measurements

1985 • 56 citations

31P-NMR saturation transfer measurements of exchange between Pi and ATP in the reactions catalysed by glyceraldehyde-3-phosphate dehydrogenase and phosphoglycerate kinase in vitro

1987 • 53 citations

Quantitative analysis of nuclear overhauser effects

1985 • 52 citations

NMR studies of kinetics in cells and tissues

1987 • 52 citations

Alkaline phosphatase. 31P NMR probes of the mechanism.

1985 • 52 citations

Phosphorus-31 NMR saturation-transfer measurements in Saccharomyces cerevisiae: characterization of phosphate exchange reactions by iodoacetate and antimycin A inhibition

1987 • 47 citations

Red cell volume changes monitored using a new 31P NMR procedure

1985 • 47 citations

Magnetization transfer in the rotating frame: A new simple kinetic tool for the determination of rate constants in the slow chemical exchange range

1982 • 46 citations

³¹P NMR spin‐transfer in the phosphoglyceromutase reaction

1984 • 46 citations

Hypophosphite ion as a 31P nuclear magnetic resonance probe of membrane potential in erythrocyte suspensions

1988 • 46 citations

Saturation transfer in living systems

1980 • 45 citations

Physical basis of the effect of hemoglobin on the phosphorus-31 NMR chemical shifts of various phosphoryl compounds

1988 • 45 citations

Determination of membrane potential and cell volume by fluorine-19 NMR using trifluoroacetate and trifluoroacetamide probes

1989 • 45 citations

Nuclear magnetic resonance study of acetic acid permeation of large unilamellar vesicle membranes

1979 • 44 citations

31P-NMR saturation transfer measurements of phosphate consumption in Saccharomyces cerevisiae

1985 • 43 citations

Molecular Transfer of Nonequilibrium Nuclear Spin Magnetization

1957 • 41 citations

Application of 31P-NMR saturation transfer techniques to investigate phospholipid motion and organization in model and biological membranes

1980 • 41 citations

Contributions of nuclear magnetic resonance to renal biochemistry

1986 • 39 citations

The contribution of magnetic susceptibility effects to transmembrane chemical shift differences in the 31P NMR spectra of oxygenated erythrocyte suspensions.

1988 • 39 citations

Fourier Transform NMR Spectroscopy

1985 • 37 citations

Determination of molecular structure in solution via two-dimensional nuclear Overhauser effect experiments: proflavine as a rigid molecule test case

1984 • 36 citations

Rates of enzyme-catalyzed exchange determined by two-dimensional NMR: a study of glucose 6-phosphate anomerization and isomerization.

1983 • 36 citations

Exchange of fluorinated glucose across the red-cell membrane measured by 19F-n.m.r. magnetization transfer.

1990 • 35 citations

Ethylene glycol as a thermometer for X-nucleus spectroscopy in biological samples

1988 • 35 citations

Equilibrium exchange of dimethyl methylphosphonate across the human red cell membrane measured using NMR spin transfer

1986 • 34 citations

Direct NMR evidence that prolidase is specific for the trans isomer of imidodipeptide substrates

1986 • 33 citations

Molecular Transfer of Nonequilibrium Nuclear Spin Magnetization

1959 • 33 citations

Quantitative interpretation of a single NOESY spectrum

1988 • 33 citations

Direct quantitative analysis of enzyme-catalyzed reactions by two-dimensional nuclear magnetic resonance spectroscopy: adenylate kinase and phosphoglyceromutase

1986 • 32 citations

Glucose transport in human erythrocytes measured using ¹³C NMR spin transfer

1987 • 32 citations

CREATINE KINASE ACTIVITIES IN SKELETAL AND CARDIAC MUSCLE MEASURED BY SATURATION TRANSFER NMR

1978 • 32 citations

Dynamic parameters from nonselectively generated 1D exchange spectra

1988 • 32 citations

Nuclear Magnetic Resonance of Biological Samples

1981 • 32 citations

Water permeability of chloroplast envelope membranes

1985 • 31 citations

31P imaging of in Vivo creatine kinase reaction rates

1987 • 29 citations

Characterization of transmembrane chemical shift differences in the phosphorus-31 NMR spectra of various phosphoryl compounds added to erythrocyte suspensions

1988 • 29 citations

A comparison of 31P-NMR saturation transfer and isotope-exchange measurements of creatine kinase kinetics in vitro

1984 • 29 citations

Measurements of exchange in the reaction catalysed by creatine kinase using 14C and 15N isotope labels and the NMR technique of saturation transfer

1985 • 28 citations

Optimum mixing time for chemical kinetics by 2D NMR

1989 • 28 citations

In vivo ³¹P nuclear magnetic resonance saturation transfer measurements of phosphate exchange reactions in the yeast Saccharomyces cerevisiae

1985 • 28 citations

NMR spin exchange kinetics at equilibrium in membrane transport and enzyme systems

1983 • 27 citations

Optimizing the multisite magnetization-transfer experiment

1986 • 26 citations

Saturation transfer 31P NMR studies of the intact human red blood cell

1979 • 26 citations

31P nuclear magnetic resonance studies of crayfish (Orconectes virilis). The use of inversion spin transfer to monitor enzyme kinetics in vivo

1985 • 24 citations

A saturation transfer phosphorus nuclear magnetic resonance study of arginine phosphokinase in the muscle of a marine mollusc

1986 • 23 citations

13C NMR measurement of flux through alanine aminotransferase by inversion- and saturation-transfer methods

1985 • 23 citations

Application of 1D and 2D 23Na magnetization-transfer NMR to the study of ionophore-mediated transmembrane cation transport

1988 • 23 citations

“Overdetermined” one-dimensional NMR exchange analysis. A 1D counterpart of the 2D EXSY experiment

1989 • 22 citations

Variances of rate constants estimated from 2D NMR exchange spectra

1988 • 21 citations

Further investigation of the use of dimethyl methylphosphonate as a 31P-NMR probe of red cell volume

1988 • 21 citations

Nuclear Magnetic Resonance of Biological Samples

1981 • 20 citations

Characterization of the transport of the nonelectrolyte dimethyl methylphosphonate across the red cell membrane

1989 • 20 citations

The use of transmembrane differences in saturation transfer for measuring fast membrane transport; application to H13C03− exchange across the human erythrocyte

1987 • 20 citations

Solution conformation of lactate dehydrogenase as studied by saturation transfer ESR spectroscopy

1979 • 20 citations

Spin-lattice relaxation rates of coupled spins from 2D accordion spectroscopy

1988 • 20 citations

The distribution of tracer substrate in an enzyme-substrate system at equilibrium

1962 • 20 citations

Kinetics of creatine phosphokinase and adenylate kinase

1984 • 18 citations

Time-dependent phosphorus-31 saturation transfer in the phosphoglucomutase reaction. Characterization of the spin system for the cadmium(II) enzyme and evaluation of rate constants for the transfer process

1989 • 17 citations

Phospholipid exchange between restricted and nonrestricted domains in sarcoplasmic reticulum vesicles

1985 • 17 citations

Comparison of rate constants determined by two‐dimensional NMR spectroscopy with rate constants determined by other NMR techniques

1986 • 16 citations

A comparison of one-dimensional and two-dimensional NMR methods for measuring enzyme-catalyzed exchange

1984 • 16 citations

Mutarotase equilibrium exchange kinetics studied by 13C-NMR

1988 • 15 citations

Magnetization-transfer NMR determination of rates of exchange of solvent in and out of gel polymer beads

1985 • 14 citations

Influence of off resonance irradiation upon T1 in in Vivo saturation transfer

1986 • 12 citations

Regulation of heart creatine kinase

1987 • 12 citations

Hypophosphite transport in human erythrocytes studied by overdetermined one‐dimensional NMR exchange analysis

1990 • 11 citations

Kinetic Analysis of Multienzyme Systems in Homogeneous Solution

1985 • 9 citations

Computer simulation of the P31 NMR equations governing the creatine kinase reaction

1985 • 7 citations

Steady-state parameters of an enzyme from n.m.r. spin transfer with thermal variation

1987 • 7 citations

In Vivo Determination of ATP in Tumors Using³¹P Inversion Spin Transfer

1988 • 6 citations

31P Magnetization transfer in the phosphoglyceromutase-enolase coupled enzyme system

1988 • 6 citations

Fast transmembrane exchange in red cells studied with NMR.

1987 • 5 citations

The measurement of enzyme catalysed rates of reaction by 2D NMR spectroscopy

1984 • 2 citations