Frequent detection of aberrant RNA transcripts of theCDKN2 gene in human gastric adenocarcinoma

Basic local alignment search tool

1990 • 87,358 citations

THE TWO HISTOLOGICAL MAIN TYPES OF GASTRIC CARCINOMA: DIFFUSE AND SO‐CALLED INTESTINAL‐TYPE CARCINOMA

1965 • 5,842 citations

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

1993 • 3,680 citations

A Cell Cycle Regulator Potentially Involved in Genesis of Many Tumor Types

1994 • 2,821 citations

5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

1995 • 2,000 citations

Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers

1994 • 1,806 citations

Molecular themes in oncogenesis

1991 • 1,663 citations

A human model of gastric carcinogenesis.

1988 • 1,428 citations

Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers.

1995 • 1,353 citations

Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma

1994 • 1,142 citations

The FHIT Gene, Spanning the Chromosome 3p14.2 Fragile Site and Renal Carcinoma–Associated t(3;8) Breakpoint, Is Abnormal in Digestive Tract Cancers

1996 • 1,008 citations

Frequency of homozygous deletion at p16/CDKN2 in primary human tumours

1995 • 653 citations

Gastric carcinoma:A pathobiological classification

1977 • 538 citations

Deletion of p16 and p15 genes in brain tumors.

1994 • 416 citations

Role of the cyclin-dependent kinase inhibitors in the development of cancer

1995 • 404 citations

Frequent somatic mutation of the MTS1/CDK4I (multiple tumor suppressor/cyclin-dependent kinase 4 inhibitor) gene in esophageal squamous cell carcinoma.

1994 • 345 citations

Role of the cyclin-dependent kinase inhibitors in the development of cancer

1995 • 321 citations

Association of CDKN2A/p16INK4A with human head and neck keratinocyte replicative senescence: relationship of dysfunction to immortality and neoplasia.

1996 • 146 citations

Mutation frequency of the p16/CDKN2 gene in primary cancers in the upper digestive tract.

1995 • 81 citations

Loss of Heterozygosity on the Short Arm of Chromosome 9 without p16 Gene Mutation in Gastric Carcinomas

1995 • 29 citations