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A Neurohypophyseal Hormone Analog with Selective Oxytocin-Like Activities and Resistance to Enzymatic Inactivation: An Approach to the Design of Peptide Drugs

Data up to Jan 2025

Published1974
Citations25
References21

Total Citations Per Year

Abstract

References (21)

Cumulative dose-response curves. II. Technique for the making of dose-response curves in isolated organs and the evaluation of drug parameters.

1963 • 1,214 citations

EFFECT OF MAGNESIUM ION ON THE RESPONSE OF THE RAT UTERUS TO NEUROHYPOPHYSIAL HORMONES AND ANALOGUES1

1960 • 301 citations

A Highly Potent Analogue of Oxytocin, Desamino-oxytocin

1962 • 287 citations

Methods in investigative and diagnostic endocrinology

1975 • 242 citations

Proposed Conformation of Oxytocin in Solution

1971 • 145 citations

DIFFERENCES IN THE ANTIDIURETIC RESPONSES OF RATS TO THE INTRAVENOUS ADMINISTRATIONOF LYSINE AND ARGININE VASOPRESSINS1

1958 • 120 citations

Structure-Activity Relationships of Protein and Polypeptide Hormones

1973 • 108 citations

Comparison of the Pharmacologic Properties of Oxytocin and Its Highly Potent Analogue, Desamino-oxytocin

1962 • 75 citations

Relation of the Conformation of Oxytocin to the Biology of Neurohypophyseal Hormones

1971 • 66 citations

Evolution of antidiuretic hormones and their functions

1967 • 58 citations

Conformation of Lysine Vasopressin: A Comparison with Oxytocin

1972 • 46 citations

Selective microvascular constrictor actions of some neurohypophyseal peptides

1973 • 42 citations

1,6-Aminosuberic acid analogs of lysine- and arginine-vasopressin and -vasotocin. Synthesis and biological properties

1972 • 41 citations

A pharmacologic analysis of the significance of the chemical functional groups of oxytocin to its oxytocic activity and on the effect of magnesium on the in vitro and in vivo oxytocic activity of neurohypophysial hormones.

1967 • 39 citations

MECHANISM OF EPINEPHRINE INHIBITION OF THE MILK EJECTING RESPONSE TO OXYTOCIN.

1965 • 27 citations

Biological Significance of the Amino Acid Residue in Position 3 of Neurohypophyseal Hormones and the Effect of Magnesium on Their Uterotonic Action

1968 • 21 citations

Effect of Progesterone upon the in vivo Response of the Human Myometrium to Oxytocin and Vasopressin: Non Pregnant State

1970 • 21 citations

Inactivation of Neurohypophyseal Peptides by a Uterine Enzyme. Characterization of the Hydrolytic Cleavage

1970 • 20 citations

Control of human fertility.

1970 • 18 citations

Thiol–Protein Disulfide Oxidoreductase Activity in Human Placental Tissue Homogenates

1972 • 9 citations

[Identification of 2 new neurohypophyseal hormones, valitocin (val 8 -oxytocin) and aspartocin (asn 4 -oxytocin) in a selachian fish, the spiny dog-fish (Squalus acanthias)].

1972 • 3 citations

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A Neurohypophyseal Hormone Analog with Selective Oxytocin-Like Activities and Resistance… (1974) – Proceedings of the National Academy of Sciences | Metascience Observatory Explorer