Sample size requirements for indirect association studies of gene–environment interactions (G × E)

Mutation in blood coagulation factor V associated with resistance to activated protein C

1994 • 3,871 citations

The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes

2000 • 1,770 citations

Gene–environment interactions in human diseases

2005 • 1,074 citations

Sample size requirements for matched case‐control studies of gene–environment interaction

2001 • 616 citations

QUANTO 1.1: A computer program for power and sample size calculations for genetic-epidemiology studies

2006 • 609 citations

The complex interplay among factors that influence allelic association

2004 • 571 citations

Exploiting Gene-Environment Interaction to Detect Genetic Associations

2007 • 434 citations

Implications of Small Effect Sizes of Individual Genetic Variants on the Design and Interpretation of Genetic Association Studies of Complex Diseases

2006 • 244 citations

Gene–environment interaction and aetiology of cancer: what does it mean and how can we measure it?

2002 • 225 citations

Nutrigenomics and nutrigenetics

2004 • 200 citations

An epidemiologic approach to gene‐environment interaction

1990 • 197 citations

An utter refutation of the ‘Fundamental Theorem of the HapMap’

2006 • 180 citations

Minimum Sample Size Estimation to Detect Gene-Environment Interaction in Case-Control Designs

1994 • 123 citations

Haplotypic analysis of the TNF locus by association efficiency and entropy

2003 • 75 citations

Genetic epidemiology with a capital ?E?

2000 • 48 citations

Does accounting for gene‐environment (G×E) interaction increase the power to detect the effect of a gene in a multifactorial disease?

2003 • 26 citations