High versus low reactivity to a novel environment: behavioural, pharmacological and neurochemical assessments

Précis ofThe neuropsychology of anxiety: An enquiry into the functions of the septo-hippocampal system

1982 • 4,511 citations

Factors That Predict Individual Vulnerability to Amphetamine Self-Administration

1989 • 1,354 citations

Functions of the frontal cortex of the rat: A comparative review

1984 • 862 citations

Contribution of human hippocampal region to novelty detection

1996 • 827 citations

The nucleus accumbens as a complex of functionally distinct neuronal ensembles: An integration of behavioural, electrophysiological and anatomical data

1994 • 807 citations

Psychobiology of novelty seeking and drug seeking behavior

1996 • 672 citations

Novelty-Seeking in Rats-Biobehavioral Characteristics and Possible Relationship with the Sensation-Seeking Trait in Man

1996 • 398 citations

Ventral striatum and ventral pallidum

1982 • 388 citations

Dopaminergic activity is reduced in the prefrontal cortex and increased in the nucleus accumbens of rats predisposed to develop amphetamine self-administration

1991 • 335 citations

Conditioned and Unconditioned Stimuli Increase Frontal Cortical and Hippocampal Acetylcholine Release: Effects of Novelty, Habituation, and Fear

1996 • 326 citations

Higher and longer stress-induced increase in dopamine concentrations in the nucleus accumbens of animals predisposed to amphetamine self-administration. A microdialysis study

1993 • 262 citations

Cholinergic activity in the rat hippocampus, cortex and striatum correlates with locomotor activity: An in vivo microdialysis study

1991 • 259 citations

Regional and temporal differences in real-time dopamine efflux in the nucleus accumbens during free-choice novelty

1997 • 237 citations

Trial 2 in the elevated plus-maze: a different form of fear?

1993 • 217 citations

Predisposition to self-administer amphetamine: the contribution of response to novelty and prior exposure to the drug

1997 • 203 citations

Hippocampal acetylcholine and habituation learning

1998 • 200 citations

Individual differences in basal and cocaine-stimulated extracellular dopamine in the nucleus accumbens using quantitative microdialysis

1992 • 196 citations

Individual differences in locomotor activity and sensitization

1991 • 195 citations

The role of mesoaccumbens-pallidal circuitry in novelty-induced behavioral activation

1995 • 184 citations

Activity of dopamine neurons in the behaving primate

1992 • 178 citations

The Psychobiological Model for Impulsive Unsocialized Sensation Seeking: A Comparative Approach

1996 • 173 citations

Habituation of exploratory activity in mice: A screening test for memory enhancing drugs

1982 • 171 citations

Rapid sampling of extracellular dopamine in the rat prefrontal cortex during food consumption, handling and exposure to novelty

1996 • 169 citations

“Free” versus “Forced” Exploration of a Novel Situation by Rats

1957 • 165 citations

Plasma corticosterone concentrations sensitively reflect levels of stimulus intensity in the rat

1979 • 163 citations

Individual locomotor response to novelty predicts selective alterations in D1 and D2 receptors and mRNAs

1994 • 161 citations

P-Impulsive Sensation Seeking and Its Behavioral, Psychophysiological and Biochemical Correlates

1993 • 161 citations

A Theory of the Striatum

1993 • 151 citations

Comparative behavioral and neurochemical activities of cholinergic antagonists in rats.

1993 • 139 citations

Escape, exploratory, and food-seeking responses of rats in a novel situation.

1959 • 127 citations

Interleukin-1β decreases acetylcholine measured by microdialysis in the hippocampus of freely moving rats

1991 • 126 citations

Muscarinic antagonists are anxiogenic in rats tested in the black-white box

1996 • 117 citations

Models of memory dysfunction? A comparison of the effects of scopolamine and lorazepam on memory, psychomotor performance and mood

1991 • 117 citations

Release of [3H]acetylcholine from rat hippocampal slices: Effect of septal lesion and of graded concentrations of muscarinic agonists and antagonists

1977 • 116 citations

Endogenous acetylcholine in the dorsal hippocampus reduces anxiety through actions on nicotinic and muscarinic-sub-1 receptors.

1998 • 104 citations

Effects of anticholinergic drugs on learning and memory

1983 • 103 citations

Endogenous acetylcholine in the dorsal hippocampus reduces anxiety through actions on nicotinic and muscarinic₁ receptors.

1998 • 99 citations

Increased striatal dopamine efflux follows scopolamine administered systemically or to the tegmental pedunculopontine nucleus

1996 • 86 citations

Relationship between anxiety and serotonin in the ventral striatum

1998 • 72 citations

Pharmacological characterization of nicotinic receptor-mediated acetylcholine release in rat brain—an in vivo microdialysis study

1998 • 71 citations

Comparative behavioral effects of several anticholinergic agents in rats

1968 • 71 citations

Locomotion and stereotypy induced by scopolamine: contributions of muscarinic receptors near the pedunculopontine tegmental nucleus

1997 • 66 citations

Behavioral and neuroendocrine reactivity to stress in the WKHA/WKY inbred rat strains: a multifactorial and genetic analysis

1996 • 65 citations

A video image analyzing system for open-field behavior in the rat focusing on behavioral asymmetries

1993 • 53 citations

Mesocorticolimbic dopaminergic systems and emotional states

1990 • 53 citations

Post-trial NMDA receptor allosteric blockade differentially influences habituation of behavioral responses to novelty in the rat

1990 • 52 citations

Behavioural comparisons between individually- and group-housed male rats: Effects of novel environments and diurnal rhythm

1982 • 51 citations

Changes in exploratory activity following stimulation of hippocampal 5‐HT1A and 5‐HT1B receptors in the rat

1995 • 49 citations

Effects of scopolamine and its quaternary analogue in the murine elevated plus-maze test of anxiety

1995 • 49 citations

Microinjections of a nicotinic agonist into dopamine terminal fields: Effects on locomotion

1990 • 49 citations

Hippocampal muscarinic cholinergic mediation of spontaneous alternation and fear in the developing rat

1987 • 44 citations

Short-term effects of ether, equithesin and droperidol/fentanyl on catecholamine and indolamine metabolism in the brain of the rat

1987 • 41 citations

Individual differences in schedule-induced and conditioned behaviors

1994 • 38 citations

Effects of illumination and handling upon rat open field activity

1995 • 35 citations

Dose-response effects of scopolamine on activity in an open field

1975 • 33 citations

Different effects of scopolamine on extracellular acetylcholine levels in neostriatum and nucleus accumbens measured in vivo: possible interaction with aversive stimulation

1994 • 28 citations

Cholinergic influences in habituation of exploratory activity in mice.

1974 • 20 citations

Interactions of cholinergic and glutamatergic neuronal systems in the functional activation of cerebral blood flow response: a PET study in unanesthetized monkeys

1998 • 19 citations

Long-Term Habituation to Novel Environment: Amnesic and Hypermnesic Effects of Various Post-Exposure Treatments

1979 • 16 citations

Involvement of Septal Muscarinic Receptors in Cholinergically Mediated Changes in Rat Rearing Activity

1997 • 12 citations

Long-Term Habituation of θ-Related Activity Components of Albino Rats in the Làt-Maze

1996 • 9 citations

Effects of intrastriatal and intracortical scopolamine on behavior in rats

1984 • 5 citations