Demonstration of a change in the rate-determining step in papain- and ficin-catalyzed acyl-transfer reactions

Structure of Papain

1968 • 473 citations

Mapping the active site of papain with the aid of peptide substrates and inhibitors

1970 • 410 citations

Kinetics of Papain-Catalyzed Hydrolysis of α-N-Benzoyl-L-arginine Ethyl Ester and α-N-Benzoyl-L-argininamide¹

1965 • 204 citations

A computer program for fitting data to the Michaelis-Menten equation

1967 • 148 citations

Ficin. I. Its isolation and characterization

1968 • 123 citations

The Preparation and Properties of trans-Cinnamoyl-Papain¹

1966 • 119 citations

DIRECT EVIDENCE FOR AN ACYLATED THIOL AS AN INTERMEDIATE IN PAPAIN- AND FICIN-CATALYSED HYDROLYSES

1965 • 106 citations

The Kinetics of the Papain-Catalyzed Hydrolysis of Esters of Carbobenzoxyglycine. Evidence for an Acyl-Enzyme Intermediate^*

1966 • 105 citations

PAPAIN-CATALYSED HYDROLYSIS OF SOME HIPPURIC ESTERS. A NEW MECHANISM FOR PAPAIN-CATALYSED HYDROLYSIS

1965 • 78 citations

The structure and mechanism of action of papain

1970 • 77 citations

Binding sites for substrate leaving groups and added nucleophiles in papain-catalyzed hydrolyses

1969 • 60 citations

pH dependencies of individual rate constants in papain-catalyzed reactions

1969 • 55 citations

Evidence for conformational restrictions within the active site of acyl papains which influence the rates of hydrolysis

1970 • 47 citations

The Activation of Papain and the Inhibition of the Active Enzyme by Carbonyl Reagents

1969 • 38 citations

KINETICS OF PAPAIN ACTION

1958 • 30 citations

The kinetic analysis of hydrolytic enzyme catalyses: Consequences of non‐productive binding

1968 • 28 citations

The reaction of trans-cinnamoyl-papain with a series of polyglycinamides of varying chain length

1967 • 27 citations

Ficin- and papain-catalyzed reactions. Changes in reactivity of the essential sulfhydryl group in the presence of substrates and competitive inhibitors

1969 • 27 citations

Papain-Catalyzed Reactions of Esters with Alcohols. The Nature of the Rate-Determining Step^*

1967 • 27 citations

The presteady-state kinetics of the papain-catalyzed hydrolysis of isomeric nitrophenyl esters of carbobenzoxyglycine

1968 • 13 citations

The ficin‐catalysed hydrolysis of p‐nitrophenyl hippurate. Detailed kinetics including the measurement of the apparent dissociation constant for the enzyme‐substrate complex

1969 • 13 citations

The Three-Dimensional Structure of Papain

1970 • 10 citations