The Interferons and Their Inducers: Molecular and Therapeutic Considerations

Virus interference. I. The interferon

1957 • 3,331 citations

On the Regulation of Gene Activity

1961 • 866 citations

Interferon-Like Virus-Inhibitor Induced in Human Leukocytes by Phytohemagglutinin

1965 • 710 citations

Inducers of interferon and host resistance. II. Multistranded synthetic polynucleotide complexes.

1967 • 699 citations

Control of Specific Gene Expression in Higher Organisms

1969 • 544 citations

Effect of Virus Infections on the Function of the Immune System

1970 • 333 citations

Immune Specific Induction of Interferon Production in Cultures of Human Blood Lymphocytes

1969 • 307 citations

Inducers of interferon and host resistance. I. Double-stranded RNA from extracts of Penicillium funiculosum.

1967 • 269 citations

FOREIGN NUCLEIC ACIDS AS THE STIMULUS TO MAKE INTERFERON

1963 • 207 citations

Glycoproteins: Their Biochemistry, Biology and Role in Human Disease

1969 • 193 citations

Double-stranded RNA in Vaccinia Virus Infected Cells

1969 • 191 citations

Tilorone Hydrochloride: An Orally Active Antiviral Agent

1970 • 189 citations

Patterns of Interferon Appearance in Mice injected with Bacteria or Bacterial Endotoxin

1964 • 182 citations

INHIBITION OF TUMOR GROWTH BY POLYINOSINIC-POLYCYTIDYLIC ACID

1969 • 182 citations

INCREASED SURVIVAL IN MICE INOCULATED WITH TUMOR CELLS AND TREATED WITH INTERFERON PREPARATIONS

1969 • 176 citations

Effect of Lithium on Human Aggression

1971 • 174 citations

Molecular basis of interferon action: Inhibition of viral RNA translation

1966 • 171 citations

Regulation of Cellular Interferon Production: Enhancement by Antimetabolites

1970 • 158 citations

The interaction of human macrophages and lymphocytes in the phytohemagglutinin-stimulated production of interferon

1971 • 148 citations

Interferon Appearance Stimulated by Endotoxin, Bacteria, or Viruses in Mice Pre-Treated with Escherichia coli Endotoxin or Infected with Mycobacterium tuberculosis

1965 • 145 citations

Enhancement of Chikungunya virus replication and inhibition of interferon production by actinomycin D

1963 • 144 citations

Interferon-Like Viral Inhibitor in Rabbits after Intravenous Administration of Endotoxin

1964 • 138 citations

Tilorone Hydrochloride: Mode of Action

1970 • 137 citations

THE SPECIFICITY OF INTERFERON INDUCTION IN CHICK EMBRYO CELLS BY HELICAL RNA

1969 • 136 citations

Interferon Production by Inactivated Newcastle Disease Virus in Cell Cultures and in Mice

1966 • 130 citations

Viruses in Fungi and Interferon Stimulation

1968 • 128 citations

Induction of Circulating Interferon by Synthetic Anionic Polymers of Known Composition

1967 • 125 citations

RABBIT MACROPHAGE INTERFERONS

1967 • 124 citations

Interferon Induction Increased through Chemical Modification of a Synthetic Polyribonucleotide

1969 • 123 citations

Interferon-stimulating and in vivo antiviral effects of various synthetic anionic polymers

1968 • 121 citations

Reconstitution of a functional membrane enzyme system in a monomolecular film

1970 • 120 citations

Post-Transcriptional Control of Interferon Synthesis

1971 • 120 citations

Interferon Induction in Man by a Synthetic Polyanion of Defined Composition

1967 • 113 citations

Interferon: Protection of Cells Infected with an Intracellular Protozoan ( Toxoplasma gondii )

1968 • 113 citations

STUDIES ON PERSISTENT INFECTIONS OF TISSUE CULTURES

1959 • 113 citations

Inducers of interferon and host resistance, V. In vitro studies.

1968 • 111 citations

Inhibition of Biologic Activity of Poly I: Poly C by Human Plasma

1970 • 107 citations

Requirement of a Stable Secondary Structure for the Antiviral Activity of Polynucleotides

1969 • 107 citations

Induction of interferon synthesis by synthetic double-stranded polynucleotides

1968 • 106 citations

Leukocytes and Interferon in the Host Response to Viral Infections II. Enhanced Interferon Response of Leukocytes from Immune Animals

1966 • 104 citations

Influence of inhibitors of protein synthesis on interferon formation in mice

1965 • 104 citations

Enhanced interferon production from chick embryo cells aged in in vitro

1967 • 100 citations

Interferon Inducers Protect Mice against Plasmodium berghei Malaria

1968 • 94 citations

A PLAQUE ASSAY FOR ENUMERATING ANTIGEN-SENSITIVE CELLS IN DELAYED-TYPE HYPERSENSITIVITY

1970 • 92 citations

Virus Replication and High-Titered Interferon Production in Human Leukocyte Cultures Inoculated with Newcastle Disease Virus

1966 • 89 citations

THE ROLE OF INTERFERON IN VACCINIA VIRUS INFECTION OF MOUSE EMBRYO TISSUE CULTURE

1962 • 87 citations

Physical properties of human interferon prepared in vitro and in vivo

1966 • 83 citations

Effect of DEAE-Dextran on Production of Interferon Induced by Synthetic Double-Stranded RNA in L Cell Cultures

1968 • 83 citations

Interferon and Transcription of Early Virus-Specific RNA in Cells Infected with Simian Virus 40

1971 • 83 citations

Interferon and Cytomegalovirus in vivo and in vitro.

1967 • 83 citations

Cellular Immunity in Host Resistance to Viral Infections

1970 • 83 citations

Resistance to Virus Challenge in Mice Infected with Protozoa or Bacteria

1969 • 81 citations

Current Concepts of Interferon and Interferon Induction

1970 • 75 citations

Inhibition of RNA and interferon synthesis in Krebs-2 cells infected with vesicular stomatitis virus

1966 • 72 citations

Antiviral Activity of Polyacrylic and Polymethacrylic Acids

1968 • 71 citations

Interferon Stimulation by a Double Stranded RNA of a Mycophage in Statolon Preparations

1968 • 69 citations

Exogenous Interferon and Inducers of Interferon in the Treatment of Balb/c Mice inoculated with RC19 Tumour Cells

1969 • 69 citations

Interferon production in mice by double-stranded synthetic polynucleotides: Induction or release?

1968 • 69 citations

The results of controlled observations on the prophylaxis of influenza with interferon.

1969 • 69 citations

Interferon Inducers in vitro: Difference in Sensitivity to Inhibitors of RNA and Protein Synthesis

1968 • 68 citations

A Comparison of the Efficacy of Endogenous, Exogenous, and Combined Endogenous-Exogenous Interferon in the Treatment of Mice Infected with Encephalomyocarditis Virus

1969 • 68 citations

THE RETICULOENDOTHELIAL EFFECTS OF INTERFERON INDUCERS: POLYANIONIC AND NON‐POLYANIONIC PHYLAXIS AGAINST MICROORGANISMS *

1970 • 66 citations

Interferon and cyclic-3′5′-adenosine monophosphate: Potentiation of antiviral activity

1969 • 66 citations

Interferon Induced by Plasmodium berghei

1968 • 65 citations

Interferon and Cell Division. II. Influence of Various Experimental Conditions on the Inhibition of L1210 Cell Multiplication <italic>In Vitro</italic> by Interferon Preparations<xref ref-type="fn" rid="FN2">2</xref>

1970 • 65 citations

Effect of Interferon Treatment on Interferon Production

1966 • 65 citations

In vitro and in vivo Antiviral Action of an Interferon-Like Substance Induced by Toxoplasma gondii

1966 • 65 citations

Effect of Interferon, Polyacrylic Acid, and Polymethacrylic Acid on Tail Lesions in Mice Infected with Vaccinia Virus

1968 • 64 citations

Stimulation of Interferon Production in Human Lymphocytes by Mitogens

1967 • 63 citations

Interferon

1964 • 63 citations

Antiviral Activity of Double Stranded RNA from a Virus isolated from Aspergillus foetidus

1970 • 62 citations

Molecular aspects of endotoxic reactions.

1969 • 62 citations

RABBIT MACROPHAGE INTERFERONS

1967 • 62 citations

Exogenous Interferon protects Mice against Plasmodium berghei Malaria

1970 • 62 citations

METABOLIC DETERMINANTS OF THE INDUCTION OF INTERFERON BY A SYNTHETIC DOUBLE‐STRANDED POLYNUCLEOTIDE IN RABBIT KIDNEY CELLS

1970 • 61 citations

Induction of Interferon in Mice Infected with Toxoplasma gondii.

1966 • 59 citations

Ribosomes: Effect of Interferon on Their Interaction with Rapidly Labeled Cellular and Viral RNA's

1967 • 58 citations

Cytochemical Assay of Interferon Produced by Duck Hepatitis Virus

1963 • 58 citations

Tolerance to the Induction of Interferons by Endotoxin and Virus: Role of a Humoral Factor.

1965 • 57 citations

Suppression of Interferon and Antibody and Multiplication of Newcastle Disease Virus in Gytomegalovirus Infected Mice.

1967 • 57 citations

FACTORS INFLUENCING THE EVOLUTION OF VIRAL DISEASES AT THE CELLULAR LEVEL AND IN THE ORGANISM1

1959 • 56 citations

Role of interferon during viremia. II. Protective action of circulating interferon.

1966 • 56 citations

FOOT-AND-MOUTH DISEASE VIRUS INHIBITION INDUCED IN MICE BY SYNTHETIC DOUBLE-STRANDED RNA (POLYRIBOINOSINIC AND POLYRIBOCYTIDYLIC ACIDS)

1969 • 55 citations

STRUCTURAL REQUIREMENTS FOR SYNTHETIC POLYANIONS TO ACT AS INTERFERON INDUCERS *

1970 • 53 citations

Efficacy of Interferon in the Treatment of Mice with Established Friend Virus Leukemia

1968 • 53 citations

Induction of Resistance to Bacterial Infections of Mice with Poly I·poly C

1970 • 52 citations

Mechanism of Recovery from Viral Infection in the Chick Embryo

1961 • 51 citations

Bis-DEAE-Fluorenone: Mechanism of Antiviral Protection and Stimulation of Interferon Production in the Mouse

1971 • 51 citations

Interferon and Murine Leukemia. V. Effect of Interferon Preparations on the Evolution of Rauscher Disease in Mice

1968 • 49 citations

Local and Systemic Protection by Synthetic Polyanionic Interferon Inducers in mice against Intranasal Vesicular Stomatitis Virus

1969 • 49 citations

Penicillium cyaneo-fulvum Virus and Interferon Stimulation

1969 • 48 citations

Inhibitory Effect of Interferon on Murine Sarcoma and Leukaemia Virus Infection in vitro

1969 • 48 citations

Interferon

1965 • 48 citations

Age-related Cellular Resistance of the Chicken Embryo to Viral Infections. I. Interferon and Natural Resistance to Myxoviruses and Vesicular Stomatitis Virus

1970 • 47 citations

Interferons

1962 • 47 citations

PRODUCTION OF AN INTERFERON BY L CELLS INFECTED WITH WESTERN EQUINE ENCEPHALOMYELITIS VIRUS

1963 • 47 citations

Effect of DEAE-Dextran on Interferon Production and Protective Effect in Mice Treated with the Double-Stranded Polynucleotide Complex Polyinosinic-Polycytidylic Acid

1969 • 45 citations

Interferon Response of Human Leukocytes during Intrauterine and Postnatal Life

1968 • 45 citations

The mechanism of stimulation of interferon production by a complexed polyribonucleotide

1970 • 45 citations

Studies of adenovirus-SV40 hybrid viruses, VI. Differential effects of interferon on SV40 and adenovirus T antigen formation in cells infected with SV40 virus, adenoviruses, and adenovirus-SV40 hybrid viruses.

1967 • 44 citations

Virus-induced alterations of lymphoid tissues

1970 • 44 citations

New Method for measuring Density of Seawater

1971 • 43 citations

PRODUCTION OF INTERFERON FOLLOWING AN IMMUNE RESPONSE

1970 • 42 citations

Immunology of interferons. II. Heterospecific activities of human interferons and their neutralization by antibody.

1970 • 42 citations

Effective antiviral therapy of two murine leukemias with an interferon‐inducing synthetic carboxylate copolymer

1969 • 40 citations

Protein Synthesis in Cell-Free Systems: an Effect of Interferon

1971 • 39 citations

Interferon production by the spleen of rats after intravenous injection of Sindbis virus or heat-killed Escherichia coli

1966 • 38 citations

VIRAL INTERFERENCE. SOME CONSIDERATIONS OF BASIC MECHANISMS AND THEIR POTENTIAL RELATIONSHIP TO HOST RESISTANCE1

1960 • 38 citations

INDUCTION OF INTERFERON BY PREPARATIONS OF SYNTHETIC SINGLE-STRANDED RNA

1969 • 37 citations

Double-Stranded RNAs (Poly I:C) in the Prevention of Viral Infections

1970 • 37 citations

Characteristics of Interferon Induced in vitro and in vivo by a TRIC Agent.

1966 • 36 citations

Transfer of Interferon-Producing Macrophages: New Approach to Viral Chemotherapy

1970 • 36 citations

The Growth-Regulating Activity of Polyanions: A Theoretical Discussion of Their Place in the Intercellular Environment and their role in Cell Physiology

1969 • 36 citations

Absence of Circulating Interferon in Patients with Infectious and Serum Hepatitis

1968 • 35 citations

Interferon Production by T4 Coliphage

1970 • 35 citations

Interferon: Evidence for Subunit Structure

1970 • 35 citations

Interferon Synthesis in X-Irradiated Animals III. The High Radiosensitivity of Myxovirus-Induced Circulating Interferon Production

1969 • 35 citations

SENSITIVITY OF COMMON RESPIRATORY VIRUSES TO AN INTERFERON INDUCER IN HUMAN CELLS

1969 • 35 citations

Stimulating interaction between viruses (stimulons).

1967 • 34 citations

Inhibitory Effect of Interferon Preparations on the Development of Foci of Altered Cells Induced in vitro by Mouse Sarcoma Virus

1968 • 34 citations

A MUSHROOM EXTRACT AS AN INTERFERON INDUCER

1970 • 33 citations

Fetal Response to Viral Infection: Interferon Production in Sheep

1970 • 33 citations

The Interferon Refractory State: in Vivo and in Vitro Studies of Its Mechanism

1971 • 33 citations

Rapid Sensitive Assay for Interferons Based on the Inhibition of MM Virus Nucleic Acid Synthesis

1970 • 32 citations

Comparison of the Antitumor Effect of Interferon and Interferon Inducers

1971 • 32 citations

A factor capable of enhancing virus replication appearing in parainfluenza virus type 1 (HVJ1)-infected allantoic fluid

1965 • 31 citations

Repression of Interferon Action: Induced Dedifferentiation of Embryonic Cells

1971 • 30 citations

“Species Specificity” of Interferons: a Misnomer?

1967 • 30 citations

Synthetic Double-stranded RNA: Inhibitory Effect on Murine Leukaemia and Sarcoma Viruses in Cell Cultures

1969 • 29 citations

Failure to demonstrate a Relationship between Scrapie and Production of Interferon in Mice

1968 • 29 citations

Interférons humains induits in vitro par des polynucléotides synthétiques

1969 • 28 citations

Additional studies of interferon production by human leukemic leukocytes in vitro.

1969 • 28 citations

Interferon in Mice: Protection against Small Doses of Virus

1967 • 28 citations

Protein-Synthetic Activity of Ribosomes from Interferon-Treated Cells

1970 • 28 citations

Circulating Interferon-like Viral Inhibitor in Patients with Meningitis Due toHaemophilus influenzae

1965 • 28 citations

An interferon antagonist: Its effect on interferon action in mengo-infected ehrlich ascites tumor cells

1967 • 27 citations

Sparing Effect of Serum from Mice treated with Endotoxin upon Certain Murine Virus Diseases

1959 • 27 citations

Effect of Interferon on Tric Agents and Induction of Interferon by Tric Agents

1967 • 27 citations

Factors Influencing the Interferon Response

1970 • 26 citations

Effects of Interferon Inducers on the Intracellular Growth of the Protozoan Parasite, Leishmania donovani

1970 • 26 citations

Characterization of Virus- and Endotoxin-induced Interferons Obtained from the Serum and Urine of Rabbits

1967 • 26 citations

INTERFERON PRODUCTION IN MICE BY CELL WALL MUTANTS OF SALMONELLA TYPHIMURIUM. III. ROLE OF LIPID MOIETY OF BACTERIAL LIPOPOLYSACCHARIDE IN INTERFERON PRODUCTION IN ANIMALS *

1970 • 26 citations

Failure of Interferon to Modify Scrapie in the Mouse

1969 • 26 citations

Non-Production of Interfering Substances by Serum from Patients with Infectious Hepatitis

1968 • 26 citations

Double Stranded RNA from Rat Liver induces Interferon in Rat Cells

1971 • 26 citations

Relationship Between Dose Size and Dose Interval of Polyinosinic-Polycytidylic Acid and Interferon Hyporesponsiveness in Mice

1970 • 25 citations

DEPRESSION OF INTERFERON PRODUCTION IN MICE AFTER TREATMENT WITH ANTI-LYMPHOCYTE SERUM

1969 • 25 citations

Role of the Spleen in Interferon Production in Mice.

1966 • 25 citations

Induction of Interferon by the Bour Strain of Trachoma in Hela 229 Cells

1967 • 25 citations

Relationship of Molecular Size of rIn:rCn (Poly I:C) to Induction of Interferon and Host Resistance

1970 • 25 citations

Interferon and Interferon Inducers in the Treatment of Malignancies

1970 • 23 citations

Inhibition of polyoma-virus oncogenesis in rats by polyriboinosinic-ribocytidylic acid

1970 • 22 citations

Enhancement of Interferon Titers by Poly-L-Ornithine.

1967 • 22 citations

Antiviral Activity of an Interferon-Inducing Synthetic Polymer

1969 • 21 citations

Investigations on a Tissue Antagonist of Interferon (TAI)

1969 • 21 citations

Exogenous interferon in animals and its clinical implications.

1970 • 20 citations

Latent Infection in Marine Fish Cell Tissue Cultures.

1966 • 20 citations

Interferon stimulated by Double Stranded RNA

1970 • 20 citations

Effect of Cyclophosphamide on the Production of Interferon

1968 • 20 citations

Induction of an Interferon-Like Inhibitor by Trypanosoma Cruzi Infection in Mice *

1970 • 20 citations

Induction of Ocular Resistance to Vaccinia Virus by Typhoid Vaccine: Role of Interferon

1969 • 19 citations

Effectiveness of an Interferon Stimulator in Immunosuppressed Mice

1971 • 18 citations

Effect of the Interferon Stimulator Polyinosinic-Polycytidylic Acid on Experimental Trypanosoma cruzi Infection1,2

1971 • 17 citations

Interferon Induction and Resistance to Virus Infection in Mice Infected with Brucella abortus

1970 • 17 citations

Quantitative Assay of Interferon by the Immunofluorescent Cell-counting Technique

1969 • 16 citations

IN OVO INHIBITION OF THE GROWTH OF TRIC AGENTS BY PURIFIED SPECIES‐SPECIFIC INTERFERON

1967 • 15 citations

Interferon production in mice by vesicular stomatitis virus

1968 • 15 citations

Purified Rabbit Interferon: Attempts to Demonstrate Interferon-Specific 3 H-Protein

1970 • 15 citations

Effect of Statolon on Acute and Persistent Murine Leukemia and Sarcoma Virus Infections

1969 • 15 citations

Age-related Cellular Resistance of the Chicken Embryo to Viral Infections. II. Inducible Resistance Produced by Influenza Virus and Escherichia coli

1970 • 15 citations

Influence of Basic Substances on the Induction of the Interferon Mechanism

1970 • 14 citations

Two Mechanisms of Cell Resistance to Repeated Stimulation of Interferon

1970 • 14 citations

INTERFERON SYNTHESIS IN X-IRRADIATED ANIMALS, IV. DONOR-TYPE SERUM INTERFERONS IN RAT-TO-MOUSE RADIATION CHIMERAS INJECTED WITH NEW CASTLE DISEASE VIRUS

1969 • 14 citations

Induction of Interference and Interferon Synthesis by Non-Replicating Molluscum Contagiosum Virus

1967 • 14 citations

Role of Interferon-Like Viral Inhibitor in Endotoxin-Induced Corneal Resistance to Newcastle Disease Virus

1966 • 14 citations

Variations in the Abilities of Several Lines of L Cells to Produce and to Be Affected by Interferon

1965 • 13 citations

SENSITIVITY OF RABBIT CELLS TO PRIMATE INTERFERONS *

1970 • 13 citations

Induction of Interferon and Viral Resistance i n Animals by Polynucleotides

1970 • 13 citations

Interferons: Purification and Physicochemical Aspects

1970 • 13 citations

Patterns of Cycloheximide and Puromycin Effect on Interferon Production Stimulated by Virus or Polyribonucleotide in Different Tissues

1971 • 13 citations

Interferon induction by and ribonuclease sensitivity of thiophosphate-substituted polyribonucleotides.

1969 • 12 citations

Stimulation of Interferon Production by Mannans

1970 • 12 citations

Role of Liver in the Inactivation of Interferon

1968 • 12 citations

Interferon Action in Heterokaryons

1969 • 12 citations

Mechanism of Action of 2-Mercapto-1(β-4-pyridethyl)benzimidazole: A Reversible Inhibitor of Interferon Activity

1970 • 12 citations

IN VITRO AND IN VIVO STUDIES WITH STATOLON AGAINST INFLUENZA VIRUS

1970 • 11 citations

Role of Adrenal Cortical Function in Toxicity of Polyriboinosinic·Polyribocytidylic Acid and Its Component Homopolymers

1970 • 10 citations

EFFECT OF POLY I: C IN MICE INJECTED WITH JAPANESE B ENCEPHALITIS VIRUS *

1970 • 10 citations

Interferon Induction by Heat-Inactivated Semliki Forest Virus

1970 • 10 citations

Comparative studies with the Zilber (Carr) strain of Rous sarcoma virus (Z-RSV)

1967 • 10 citations

Statolon-Induced Resistance of Mice to Lethal Aerosols of Columbia-SK Virus

1968 • 9 citations

Maternal and fetal interferon production in the rat

1970 • 9 citations

Applied and induced interferon in the prophylaxis and treatment of leukemia.

1970 • 9 citations

Effect of polyacrylic acid on experimental malaria and trypanosomiasis in mice

1970 • 9 citations

Induction of Interferon in Chick Cells by Adenoviruses of Different Origin

1970 • 9 citations

A virus inhibitor circulating in the blood of chickens, induced byFrancisella tularensis andListeria monocytogenes

1967 • 8 citations

TRITIUM‐LABELLED L CELL INTERFERON: FURTHER CHARACTERIZATION AND PURIFICATION BY ELECTROPHORESIS IN POLYACRYLAMIDE GELS

1970 • 7 citations

Molecular Aspects of Interferon Induction by Viruses

1970 • 6 citations

Induction of Interferon by Coxiella burneti in Cell Cultures

1968 • 5 citations

ORDER SPECIFICITY OF CERTAIN AVIAN INTERFERONS

1970 • 5 citations

Production of Interferon in Primary Chick Embryonic Cells Infected with Rickettsia Mooseri

1970 • 4 citations

Interferon as a Metabolic Agent of Host Resistance

1962 • 4 citations

Age-Related Cellular Resistance of the Chicken Embryo to Viral Infections III. Escherichia coli resistance-inducing protein

1970 • 4 citations

INTERFERON PRODUCTION IN LEUKOCYTES AND THE ANTIVIRAL PROTECTION OF MICE TREATED WITH ENDOTOXIN

1970 • 3 citations

[Enzymatic and morphologic modifications in Brucella suis treated with interferon].

1967 • 2 citations