Replication Protein A Physically Interacts with the Bloom's Syndrome Protein and Stimulates Its Helicase Activity

Positional Cloning of the Werner's Syndrome Gene

1996 • 1,696 citations

REPLICATION PROTEIN A: A Heterotrimeric, Single-Stranded DNA-Binding Protein Required for Eukaryotic DNA Metabolism

1997 • 1,417 citations

The Bloom's syndrome gene product is homologous to RecQ helicases

1995 • 1,371 citations

The yeast type I topoisomerase Top3 interacts with Sgs1, a DNA helicase homolog: a potential eukaryotic reverse gyrase.

1994 • 686 citations

Mutations in RECQL4 cause a subset of cases of Rothmund-Thomson syndrome

1999 • 657 citations

ESCHERICHIA COLI SINGLE-STRANDED DNA-BINDING PROTEIN: Multiple DNA-Binding Modes and Cooperativities

1994 • 604 citations

Bloom Syndrome

1993 • 529 citations

The Bloom's Syndrome Helicase Unwinds G4 DNA

1998 • 524 citations

Sgs1: A eukaryotic homolog of E. coil RecQ that interacts with topoisomerase II in vivo and is required for faithful chromosome segregation

1995 • 402 citations

SGS1, a Homologue of the Bloom's and Werner's Syndrome Genes, Is Required for Maintenance of Genome Stability in Saccharomyces cerevisiae

1996 • 380 citations

The Bloom's Syndrome Gene Product Is a 3′-5′ DNA Helicase

1997 • 378 citations

rqh1+, a fission yeast gene related to the Bloom's and Werner's syndrome genes, is required for reversible S phase arrest

1997 • 354 citations

The Bloom's Syndrome Gene Product Interacts with Topoisomerase III

2000 • 313 citations

Functional and Physical Interaction between WRN Helicase and Human Replication Protein A

1999 • 302 citations

DNA helicases: Enzymes with essential roles in all aspects of DNA metabolism

1994 • 294 citations

The role of human single-stranded DNA binding protein and its individual subunits in simian virus 40 DNA replication.

1990 • 254 citations

Cloning of Two New Human Helicase Genes of the RecQ Family: Biological Significance of Multiple Species in Higher Eukaryotes

1998 • 252 citations

RecQ DNA helicase is a suppressor of illegitimate recombination in Escherichia coli

1997 • 246 citations

Cytogenetics of Werner’s syndrome cultured skin fibroblasts: variegated translocation mosaicism

1981 • 241 citations

Defending genome integrity during DNA replication: a proposed role for RecQ family helicases

1999 • 212 citations

Evidence for increased in vivo mutation and somatic recombination in Bloom's syndrome.

1989 • 200 citations

Molecular genetics of Bloom's syndrome

1996 • 193 citations

Ultraviolet light sensitivity and delayed DNA-chain maturation in Bloom's syndrome fibroblasts

1977 • 162 citations

DNA-dependent nucleoside 5'-triphosphatase activity of the gene 4 protein of bacteriophage T7.

1983 • 151 citations

Molecular cloning of cDNA encoding human DNA helicase Q1 Which has homology toEscherichia coliRec Q helicase and localization of the gene at chromosome 12p12

1994 • 146 citations

The DNA Helicase Activity of BLM Is Necessary for the Correction of the Genomic Instability of Bloom Syndrome Cells

1999 • 135 citations

The recQ gene of Escherichia coli K12: molecular cloning and isolation of insertion mutants

1985 • 132 citations

Oligomeric ring structure of the Bloom's syndrome helicase

1999 • 129 citations

DNA helicase II of Escherichia coli. Characterization of the single-stranded DNA-dependent NTPase and helicase activities.

1987 • 117 citations

A preformed, topologically stable replication fork. Characterization of leading strand DNA synthesis catalyzed by T7 DNA polymerase and T7 gene 4 protein.

1983 • 113 citations

An abnormal profile of DNA replication intermediates in Bloom's syndrome.

1990 • 107 citations

Bloom’s syndrome protein, BLM, colocalizes with replication protein A in meiotic prophase nuclei of mammalian spermatocytes

1999 • 103 citations

Rothmund‐Thomson syndrome in siblings: evidence for acquired in vivo mosaicism

1996 • 85 citations

Isolation of a DNA helicase from HeLa cells requiring the multisubunit human single-stranded DNA-binding protein for activity

1991 • 80 citations

The 32- and 14-Kilodalton Subunits of Replication Protein A Are Responsible for Species-Specific Interactions with Single-Stranded DNA

1998 • 74 citations

Point mutations causing Bloom's syndrome abolish ATPase and DNA helicase activities of the BLM protein

1998 • 69 citations

Growth Characteristics of Werner Syndrome Cells in Vitro

1985 • 66 citations

Homologous recombination is elevated in some Werner-like syndromes but not during normal in vitro or in vivo senescence of mammalian cells

1990 • 58 citations

Autoradiographic Studies of DNA Replication in Werner’s Syndrome Cells

1985 • 53 citations