Heavy metal toxicities

Metallothionein: a Cadmium- and Zinc-containing Protein from Equine Renal Cortex

1960 • 965 citations

Biological Methylation of Mercury in Aquatic Organisms

1969 • 940 citations

Metallothionein: a Cadmium and Zinc-containing Protein from Equine Renal Cortex

1961 • 685 citations

The Possible Significance of the Ferrous Oxidase Activity of Ceruloplasmin in Normal Human Serum

1966 • 672 citations

Selenium: Relation to Decreased Toxicity of Methylmercury Added to Diets Containing Tuna

1972 • 623 citations

Synthesis of Methyl-mercury Compounds by Extracts of a Methanogenic Bacterium

1968 • 541 citations

Trace element metabolism in animals.

1970 • 470 citations

Newer trace elements in nutrition.

1971 • 403 citations

THE DESTRUCTIVE EFFECT OF CADMIUM ION ON TESTICULAR TISSUE AND ITS PREVENTION BY ZINC

1957 • 393 citations

Copper homeostasis in the mammalian system.

1973 • 342 citations

Isolation and Some Properties of Human Metallothionein^*

1966 • 326 citations

The Human Body Burden of Lead

1968 • 321 citations

Cadmium as a factor in hypertension

1965 • 306 citations

Experimental enhancement of lead toxicity by low dietary calcium.

1970 • 275 citations

Accumulation and Retention of Mercury in the Mouse

1963 • 265 citations

Binding of cadmium ions by rat liver and kidney

1972 • 261 citations

Iron metabolism in copper-deficient swine

1968 • 258 citations

The influence of iron deficiency on tissue content and toxicity of ingested lead in the rat.

1972 • 249 citations

Separation of two forms of rabbit metallothionein by isoelectric focusing

1972 • 247 citations

Chemical parameters in the study of in vivo and in vitro interactions of transition elements.

1970 • 242 citations

FACTORS AFFECTING PROTEIN SYNTHESIS IN VITRO IN RABBIT RETICULOCYTES

1957 • 222 citations

Metallocarboxypeptidases: Stability Constants and Enzymatic Characteristics

1961 • 222 citations

Protection by zinc against cadmium toxicity

1972 • 211 citations

Proteinuria in Chronic Cadmium Poisoning

1966 • 211 citations

Changes in the distribution of hepatic copper in relation to the progression of Wilson's disease (hepatolenticular degeneration).

1968 • 189 citations

Chemical Methylation of Inorganic Mercury with Methylcobalamin, a Vitamin B ₁₂ Analog

1971 • 186 citations

Renal Damage After Prolonged Exposure to Cadmium

1966 • 173 citations

Purification and some properties of Cd-binding protein from rat liver

1972 • 167 citations

Zinc Interference with Copper Absorption in Rats

1967 • 166 citations

Environmental mercury contamination

1973 • 166 citations

In vivo Interactions of Cadmium with Copper, Zinc and Iron

1963 • 166 citations

Hemolytic Anemia in Wilson's Disease

1970 • 162 citations

Cadmium hypertension in rats

1964 • 161 citations

Studies on Growth, Copper Metabolism and Iron Metabolism of Rats Fed High Levels of Zinc

1960 • 160 citations

Studies on the Mechanism of Copper Absorption in the Chick

1969 • 156 citations

Mechanism for cadmium and zinc antagonism of copper metabolism

1970 • 155 citations

Effects of methylmercury on prenatal development in mice

1972 • 148 citations

Lead Absorption from the Intestine in Newborn Rats

1971 • 146 citations

Teratogenic Effect of Cadmium and its Inhibition by Zinc

1967 • 145 citations

Lead and protein content of isolated intranuclear inclusion bodies from kidneys of lead-poisoned rats.

1970 • 143 citations

Hemolytic Anemia in Wilson's Disease

1967 • 139 citations

Control of reticulocyte polyribosome content and hemoglobin synthesis by heme

1966 • 136 citations

The Anaemia of Lead Poisoning: A Review

1966 • 134 citations

Biotransformation of methylmercury salts in the rat studied by specific determination of inorganic mercury

1970 • 134 citations

In vivo Interactions of Cadmium, Copper, Zinc and Iron in the Mouse and Rat

1966 • 129 citations

Copper and Zinc Status of Ewes and Lambs receiving Increased Dietary Concentrations of Cadmium

1972 • 129 citations

Studies of the toxicity of copper to pigs

1966 • 128 citations

The Effect of Zinc and Other Metals on the Stability of Lysosomes

1972 • 126 citations

Studies on the assimilation and storage of copper in crossbred sheep.

1954 • 120 citations

Dose-response to lead ingestion in rats fed low dietary calcium.

1973 • 120 citations

On the Distribution of Cadmium in Blood

1971 • 118 citations

Experimental Chronic Copper Toxicity in Sheep

1971 • 116 citations

Effect of Ascorbic Acid on Cadmium Toxicity in the Young Coturnix

1971 • 115 citations

Effects of Zinc, Cadmium, Silver and Mercury on the Absorption and Distribution of Copper-64 in Rats

1966 • 114 citations

LEAD AND METHYL MERCURY: EFFECTS OF ACUTE EXPOSURE ON CYTOCHROME P-450 AND THE MIXED FUNCTION OXIDASE SYSTEM IN THE LIVER

1972 • 114 citations

Lead toxicity: a problem in environmental pathology.

1971 • 113 citations

CHANGES IN BLOOD FLOW AND VASCULAR PERMEABILITY OF THE TESTIS, EPIDIDYMIS AND ACCESSORY REPRODUCTIVE ORGANS OF THE RAT AFTER THE ADMINISTRATION OF CADMIUM CHLORIDE

1966 • 112 citations

CAUSATION OF OUCH-OUCH DISEASE (Itai-Itai Byo)-An Introductory Review

1969 • 112 citations

Binding of mercury in the rat kidney by metallothionein

1970 • 108 citations

Effect of cadmium on skeletal tissue in normal and calcium-deficient rats.

1971 • 107 citations

Effect of Excess Dietary Zinc on Iron and Copper in the Rat

1960 • 106 citations

Copper Interference with the Intestinal Absorption of Zinc-65 by Rats

1969 • 105 citations

Lead Poisoning: Rapid Formation of Intranuclear Inclusions

1972 • 104 citations

Metallic contaminants and human health

1973 • 100 citations

Effect of Zinc on Lipid Peroxidation in Liver Microsomes and Mitochondria

1972 • 98 citations

PREVENTIVE EFFECT OF PRETREATMENT WITH LOW DOSE OF METALS ON THE ACUTE TOXICITY OF METALS IN MICE

1970 • 96 citations

DNA, RNA, and protein synthesis in brain, liver, and kidneys of asymptomatic methylmercury treated rats

1973 • 93 citations

Chronic copper toxicity of ruminants

1969 • 89 citations

The Transport of Elemental Mercury into Fetal Tissues

1972 • 87 citations

Deficient Red Cell Membrane /Na⁺+ K⁺/-ATPase in Lead Poisoning

1967 • 87 citations

Selectivity of organ response to cadmium injury and various protective measures

1968 • 86 citations

PLACENTAL TRANSFER OF MERCURIC CHLORIDE, PHENYL MERCURY ACETATE AND METHYL MERCURY ACETATE IN MICE

1967 • 85 citations

Binding of mercury in the rat: Studies using 203HgCl2 and gel filtration

1970 • 81 citations

Copper and Zinc Interrelationships in the Pig

1963 • 80 citations

Certain Biological Effects of Lead Upon the Animal Organism

1971 • 80 citations

THE BIOCHEMICAL BEHAVIOR OF LEAD

1940 • 78 citations

Effects of selected chelating agents and metals on the stability of liver lysosomes

1972 • 78 citations

Wilson's disease or chronic copper poisoning?

1973 • 78 citations

Cell proliferation in rat kidney induced by lead acetate and effects of uninephrectomy on the proliferation.

1972 • 74 citations

Embryotoxicity of methyl mercuric chloride in golden hamsters

1972 • 73 citations

Maximum Daily Intake of Lead Without Excessive Body Lead-Burden in Children

1971 • 72 citations

Copper Sulfate-Induced Hemolytic Anemia

1967 • 71 citations

Studies on the pathogenesis of hepatolenticular degeneration. 3. The effect of copper on rat liver lysosomes.

1968 • 70 citations

Bone Changes in Experimental Chronic Cadmium Poisoning

1973 • 69 citations

INTRACELLULAR DISTRIBUTION OF COPPER IN THE LIVER OF THE RAT

1967 • 68 citations

Cadmium Toxicity Decreased by Dietary Ascorbic Acid Supplements

1970 • 68 citations

Subcellular distribution of lead in the rat.

1971 • 67 citations

Absorption, distribution and excretion of phenylmercuric acetate

1960 • 66 citations

ZINC TOXICITY IN THE RAT AND ITS INTERRELATION WITH COPPER

1958 • 66 citations

Ion transport by heart mitochondria

1971 • 65 citations

The renal tubule in lead poisoning. II. In vitro studies of mitochondrial structure and function.

1968 • 64 citations

Accelerated Uptake of Mercury by Brain caused by 2,3‐ Dimercaptopropanol (BAL) After Injection into the Mouse of a Methylmercuric Compound

1965 • 62 citations

Experimental Chronic Copper Toxicity in Sheep: Biochemical and Haematological Studies during the Development of Lesions in the Liver

1972 • 62 citations

Summary of recent studies in Japan on methyl mercury poisoning

1973 • 61 citations

Renal excretory mechanisms of heavy metals

1968 • 60 citations

Dietary Cadmium, Iron, and Zinc Interactions in the Growing Rat

1969 • 60 citations

Metallic contaminants and human health

1973 • 60 citations

Zinc Toxicity in Ruminants. IV. Physiological Changes in Tissues of Beef Cattle

1966 • 60 citations

Purification and properties of α-<scp>d</scp>-mannosidase from rat epididymis

1969 • 60 citations

In vivo Interference of Zinc with Ferritin Iron in the Rat

1967 • 59 citations

RESTRICTED CALCIUM FEEDING VERSUS ZINC SUPPLEMENTATION FOR THE CONTROL OF PARAKERATOSIS IN SWINE

1957 • 59 citations

Another look at lead inclusion bodies.

1968 • 57 citations

Age-dependent alterations in hepatic subcellular copper distribution and plasma ceruloplasmin

1970 • 57 citations

The Effect of Calcium and Phosphorus on the Metabolism of Lead

1941 • 56 citations

Effect of mercurial compounds on structure-linked latency of lysosomal hydrolases

1967 • 56 citations

The intracellular distribution of mercury in rat liver after a single injection of mercuric chloride

1968 • 55 citations

HISTOCHEMICAL STUDIES OF NEPHROTOXICITY WITH SUBLETHAL DOSES OF MERCURY IN RATS.

1965 • 54 citations

Zinc Toxicity in Ruminants. II. Effect of High Levels of Dietary Zinc on Gains, Feed Consumption and Feed Efficiency of Beef Cattle

1966 • 54 citations

EFFECT OF CALCIUM AND PHOSPHORUS ON RETENTION OF LEAD BY GROWING ORGANISM

1940 • 53 citations

The Effect of ACTH on the Agglutination with Sensitized Red Sheep Cells in Rheumatoid Arthritis

1950 • 53 citations

Distribution of inorganic, aryl, and alkyl mercury compounds in rats

1968 • 52 citations

Deposition of Mercury in Fetal and Maternal Brain

1972 • 51 citations

The Effect of Zinc Deficiency and Food Restriction on Hepatic Zinc Proteins in the Rat

1973 • 51 citations

Intestinal absorption of metal ions, trace elements and radionuclides

1973 • 49 citations

Effects of dietary cadmium and zinc on rats maintained on diets low in copper.

1974 • 49 citations

STUDIES IN LEAD POISONING: Comparison between different Laboratory Tests

1965 • 48 citations

Methylmercury accumulation in brains of pregnant, non-pregnant and fetal rats

1973 • 48 citations

The effect of copper on the erythrocyte hexose monophosphate shunt pathway.

1972 • 48 citations

Specificity of zinc pathway through the body: homeostatic considerations

1964 • 48 citations

Lead and zinc poisoning and the interaction between Pb and Zn poisoning in the foal.

1972 • 47 citations

Reproductive capability of male rats and mice treated with methyl mercury

1973 • 47 citations

Copper in Hepatocyte Lysosomes of the Toad, Bufo marinus L.

1970 • 46 citations

Studies on Zinc

1937 • 45 citations

RESTRICTED CALCIUM FEEDING VERSUS ZINC SUPPLEMENTATION FOR THE CONTROL OF PARAKERATOSIS IN SWINE

1957 • 44 citations

High Level Copper for Growing-Finishing Swine

1960 • 44 citations

The Diagnosis, Prevention and Treatment of Chronic Copper Poisoning in Housed Lambs

1966 • 44 citations

Zinc Toxicity in Ruminants. I. Effect of High Levels of Dietary Zinc on Gains, Feed Consumption and Feed Efficiency of Lambs

1966 • 43 citations

Reduction of lead absorption from the intestine in newborn rats

1971 • 43 citations

Distribution and Excretion of Various Mercury Compounds after Single Injections in Poultry

1968 • 43 citations

Studies of the toxicity of copper to pigs

1966 • 41 citations

BIOCHEMICAL EFFECTS OF Cd2+-INJURY IN THE RAT AND MOUSE TESTIS

1972 • 41 citations

Placental transmission of mercury to the fetal rat*1

1972 • 40 citations

Absorption, distribution, and excretion of ethylmercuric chloride

1961 • 40 citations

Influence of Vitamin D in Experimental Lead Poisoning

1938 • 39 citations

ABSORPTION OF IRON AND CHEMICALLY RELATED METALS IN VITRO AND IN VIVO: SPECIFICITY OF THE IRON BINDING SYSTEM IN THE MUCOSA OF THE JEJUNUM

1971 • 38 citations

Intracellular distribution of copper in the liver during chronic administration of copper sulfate to the rat

1971 • 38 citations

Antagonistic Relationship between Dietary Cadmium and Zinc

1963 • 37 citations

In vivo Effect of Zinc on Iron Turnover in Rats and Life Span of the Erythrocyte

1967 • 37 citations

Cytochrome content of kidney mitochondria in experimental lead poisoning

1971 • 35 citations

Studies on the Induction of a Low-Molecular-Weight Zinc-Binding Protein in Rat Liver

1973 • 34 citations

Untersuchungen �ber den Kaliumverlust bleivergifteter Menschenerythrocyten

1955 • 33 citations

Elimination, tissue accumulation, and cellular incorporation of mercury in rats receiving an oral dose of 203Hg-labeled phenylmercuric acetate and mercuric acetate*1

1967 • 33 citations

Study on the Mechanism of Lysosome Labilization by Inorganic Mercury in vitro

1972 • 32 citations

The metabolism of methoxyethylmercury salts

1971 • 32 citations

Glucose-6-phosphate and 6-Phosphogluconic Dehydrogenase Activities in the Red Blood Cells of Several Animal Species

1963 • 32 citations

Tissue Copper Proteins in Wilson's Disease

1964 • 32 citations

The effect of copper loading on the distribution of copper in rat liver cytosol

1973 • 31 citations

Subcellular distribution and enzyme changes following subacute copper intoxication.

1967 • 31 citations

Electron Probe Microanalyser Localization of Lead in Kidney Tissue of Poisoned Rats

1970 • 31 citations

In vivo effect of zinc on iron-induced ferritin synthesis in rat liver

1969 • 31 citations

CADMIUM TOXICOLOGY

1969 • 31 citations

The intracellular distribution of copper in immature liver

1961 • 31 citations

Acute toxicity of methyl mercury on glycolytic intermediates and adenine nucleotides of rat brain

1971 • 30 citations

Maternal Dietary Zinc, and Development and Zinc, Iron, and Copper Content of the Rat Fetus

1968 • 29 citations

Interference with Fecal Excretion of Zn65 by Cadmium.

1962 • 29 citations

Isolation and partial characterization of a mercury-binding nonhistone protein component from rat kidney nuclei

1973 • 29 citations

Studies on the Appearance of a Copper-Binding Protein in Rat Liver

1974 • 27 citations

Effects of protein intake on the storage of copper in the liver of sheep

1965 • 26 citations

Effects of methylmercury on microsomal mixed-function oxidase components of rodents.

1973 • 26 citations

“Swayback” Studies in North Derbyshire

1939 • 25 citations

I Distribution and excretion of various mercury compounds after single injections in poultry

1968 • 24 citations

Studies on the pathogenesis of hepatolenticular degeneration. I. Acid phosphatase activity in copper-loaded rat livers.

1967 • 23 citations

Copper, molybdenum and sulphur contents of oats and barley in relation to chronic copper poisoning in housed sheep

1972 • 23 citations

Accumulation of Cadmium in Organs of Mice Fed on Cadmium-Polluted Rice

1971 • 23 citations

Neonatal hepatic mitochondrocuprein

1971 • 22 citations

Chronic copper poisoning presenting as pink disease.

1971 • 22 citations

Transfer of metallic mercury into the foetus

1972 • 22 citations

Specific response of mesenchymal tissue to cancerigenesis by cadmium.

1967 • 22 citations

Effect of Dietary Protein and Zinc on the Absorption and Liver Deposition of Radioactive and Total Copper

1961 • 22 citations

Biliary Excretion of Mercury Enhanced by Spironolactone

1972 • 21 citations

Mammary Transfer of 203Hg from Mothers to Brains of Nursing Rats

1973 • 20 citations

Effect of Supplementary Zinc on the Intracellular Distribution of Hepatic Copper in Rats

1971 • 20 citations

TOXAEMIC JAUNDICE OF SHEEP: PHYTOGENOUS CHRONIC COPPER POISONING, HELIOTROPE POISONING, AND HEPATOGENOUS CHRONIC COPPER POISONING

1956 • 20 citations

Behavioural effects of lead and other heavy metal pollutants.

1972 • 20 citations

The autoxidation of haemoglobin. Effect of copper.

1969 • 19 citations

Swayback Studies in North Derbyshire

1940 • 18 citations

Iron and Copper Effects on Serum Ceruloplasmin Activity of Rats with Zinc-Induced Copper Deficiency

1969 • 17 citations

PERSISTENCE OF STORED Cd2+ IN THE LIVERS AND KIDNEYS OF FEMALE RATS DURING PREGNANCY

1972 • 17 citations

Autoradiographische Befunde an den « direkten » Kerneinschlüssen im Hauptstückepithel der Rattenniere nach experimenteller Bleivergiftung

1964 • 17 citations

Increased Stool Mercury Excretion in the Rat: The Effect of Spironolactone

1972 • 15 citations

Erythrocyte Copper and Porphyrins in Lead Poisoning

1958 • 15 citations

The nature and origin of the minialbumin found in cadmium-poisoned animals.

1966 • 14 citations

Inductive Effects of Methyl Mercury on the Hepatic Microsomes of Mice

1973 • 13 citations

The in vivo binding of mercury to soluble proteins of the rat kidney

1971 • 13 citations

Inhibition of heterolysosome formation and function in mouse kidneys by injection of mercuric chloride

1973 • 12 citations

Inhibition by Zinc Ions of Ferritin Formation in vitro

1973 • 10 citations

Zinc, iron, copper, calcium, cytochrome oxidase, and phospholipid in rats of lactating mothers fed excess zinc.

1972 • 8 citations

Attempts to quantitate the protective effect of selenium against mercury toxicity using Japanese quail

1973 • 8 citations

Effects of dietary copper loading on livers of rats. I. Changes in subcellular acid phosphatases and detection of an additional acid p-nitrophenylphosphatase in the cellular supernatant during copper loading.

1971 • 7 citations

Changes in activity of serum enzymes and in the LDH isoenzyme pattern in chronic Cu poisoning of sheep.

1965 • 7 citations

Nutritional Aspects of the Development of Bone and Connective Tissue

1969 • 6 citations

The effect of experimental methyl mercury poisoning on the activity of the TPNH-specific glutathione reductase of rat brain and liver.

1972 • 6 citations

Ultrastructure and Microsomal Protein Content of Mouse Liver Treated with Methyl Mercury *

1972 • 6 citations

The metabolism of lead in man in health and disease. 3. Present hygienic problems relating to the absorption of lead.

1961 • 5 citations

Studies on Microdetermination of Total Mercury and the Dynamic Aspects of Methyl Mercury Compound in Vivo

1971 • 5 citations

The Aetiology of Conditioned Copper Deficiency

1972 • 4 citations

Trace Metals and the Crosslinking System of the Protein Fibres of Connective Tissue

1969 • 3 citations

Excess dietary zinc and sub-cellular changes in hepatic zinc, iron, and copper in maternal and fetal rats.

1972 • 3 citations