A rapid assay for the brevetoxin group of sodium channel activators based on fluorescence monitoring of synaptoneurosomal membrane potential

A simplification of the protein assay method of Lowry et al. which is more generally applicable

1977 • 8,485 citations

Toxic phytoplankton blooms in the sea

1993 • 1,403 citations

Brevetoxins, unique activators of voltage-sensitive sodium channels, bind to specific sites in rat brain synaptosomes.

1986 • 313 citations

Brevetoxins: unique polyether dinoflagellate toxins

1989 • 309 citations

Ciguatoxin and brevetoxins share a common receptor site on the neuronal voltage‐dependent Na⁺ channel

1987 • 304 citations

Functional Coupling of γ-Aminobutyric Acid Receptors to Chloride Channels in Brain Membranes

1985 • 270 citations

Detection of Sodium Channel Toxins: Directed Cytotoxicity Assays of Purified Ciguatoxins, Brevetoxins, Saxitoxins, and Seafood Extracts

1995 • 234 citations

The occurrence of a ciguatera-like poison in oysters, clams, and Gymnodinium breve cultures

1965 • 170 citations

Brevetoxin-3 (PbTx-3) and its derivatives modulate single tetrodotoxin-sensitive sodium channels in rat sensory neurons.

1998 • 122 citations

Development of rapid and sensitive high throughput pharmacologic assays for marine phycotoxins

1994 • 102 citations

Toxin T4(6) from Ptychodiscus brevis (formerly Gymnodinium breve) enhances activation of voltage-sensitive sodium channels by veratridine.

1981 • 101 citations

Confirmation of brevetoxin metabolism in the Eastern oyster (Crassostrea virginica) by controlled exposures to pure toxins and to Karenia brevis cultures

2002 • 101 citations

Monitoring brevetoxins during a Gymnodinium breve red tide: comparison of sodium channel specific cytotoxicity assay and mouse bioassay for determination of neurotoxic shellfish toxins in shellfish extracts

1999 • 100 citations

Ionic Dependence of Membrane Potential and Glutamate Receptor‐Linked Responses in Synaptoneurosomes as Measured with a Cyanine Dye, DiS‐C₂‐(5)

1987 • 97 citations

Brevetoxin B1, a new polyether marine toxin from the New Zealand shellfish, Austrovenus stutchburyi

1995 • 94 citations

Clinical and epidemiological features of neurotoxic shellfish poisoning in North Carolina.

1991 • 94 citations

Monitoring brevetoxins during a Gymnodinium breve red tide: comparison of sodium channel specific cytotoxicity assay and mouse bioassay for determination of neurotoxic shellfish toxins in shellfish extracts

1999 • 90 citations

Red tide (Ptychodiscus brevis) toxin aerosols: A review

1986 • 77 citations

Distribution and elimination of ingested brevetoxin (PbTx-3) in rats

1993 • 70 citations

Photoaffinity labeling of the brevetoxin receptor on sodium channels in rat brain synaptosomes.

1991 • 64 citations

Red tide. Its public health implications.

1973 • 55 citations

Fluorescence changes of rhodamine 6G associated with changes in membrane potential in synaptosomes

1982 • 55 citations

Atrial Natriuretic Factors Stimulate Accumulation and Efflux of Cyclic GMP in C6–2B Rat Glioma and PC12 Rat Pheochromocytoma Cell Cultures

1987 • 54 citations

Nerve membrane sodium channels as the target site of brevetoxins at neuromuscular junctions

1986 • 51 citations

Stereoselective modulatory actions of oleamide on GABA_A receptors and voltage‐gated Na⁺ channels in vitro: a putative endogenous ligand for depressant drug sites in CNS

2000 • 50 citations

Allosteric modulation of neurotoxin binding to voltage-sensitive sodium channels by Ptychodiscus brevis toxin 2.

1987 • 50 citations

An enzyme immunoassay for the detection of Florida red tide brevetoxins

1991 • 41 citations

Radioimmunoassay for PbTx-2-Type Brevetoxins: Epitope Specificity of Two Anti-PbTx Sera

1995 • 40 citations

Detection, Metabolism, and Pathophysiology of Brevetoxins

1990 • 32 citations

A rapid and sensitive assay for paralytic shellfish poison (PSP) toxins using mouse brain synaptoneurosomes

2002 • 29 citations

Cardiorespiratory effects of brevetoxin (PbTx-2) in conscious, tethered rats

1989 • 28 citations

Prophylactic and therapeutic use of an anti-brevetoxin (PbTx-2) antibody in conscious rats

1989 • 26 citations

Neurological analysis of respiratory, cardiovascular and neuromuscular effects of brevetoxin in cats

1985 • 23 citations

Introduction to symposium — Brevetoxins: Chemistry and pharmacology of ‘red tide’ toxins from Ptychodiscus brevis (formerly Gymnodinium breve)

1985 • 22 citations

Health Effects Associated With Algal Toxins From Seafood

1997 • 18 citations

Actions of Ptychodiscus brevis Red Tide Toxin on Metabolic and Transmitter‐Releasing Properties of Synaptosomes

1982 • 16 citations

Cardiovascular and respiratory changes following exposure to a synthetic toxin of Ptychodiscus brevis

1995 • 12 citations

Electrophysiological and biochemical characteristics of Gymnodinium breve toxins

1978 • 9 citations