The promise of anti-angiogenic cancer therapy

Endostatin: An Endogenous Inhibitor of Angiogenesis and Tumor Growth

1997 • 4,504 citations

Thalidomide is an inhibitor of angiogenesis.

1994 • 2,460 citations

Cyclooxygenase Regulates Angiogenesis Induced by Colon Cancer Cells

1998 • 2,282 citations

Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance

1997 • 1,705 citations

Effects of Angiogenesis Inhibitors on Multistage Carcinogenesis in Mice

1999 • 990 citations

The role of αv integrins during angiogenesis: insights into potential mechanisms of action and clinical development

1999 • 651 citations

The microtubule-affecting drug paclitaxel has antiangiogenic activity.

1996 • 643 citations

The anti-angiogenic agent fumagillin covalently binds and inhibits the methionine aminopeptidase, MetAP-2

1997 • 622 citations

Endostatin Induces Endothelial Cell Apoptosis

1999 • 594 citations

Angiostatin binds ATP synthase on the surface of human endothelial cells

1999 • 520 citations

Tumor Infarction in Mice by Antibody-Directed Targeting of Tissue Factor to Tumor Vasculature

1997 • 485 citations

Endostatin: yeast production, mutants, and antitumor effect in renal cell carcinoma.

1999 • 246 citations

Oncogenes as inducers of tumor angiogenesis

1995 • 241 citations

Inhibition of tumor growth by targeting tumor endothelium using a soluble vascular endothelial growth factor receptor.

1998 • 201 citations

Cyclooxygenase Regulates Angiogenesis Induced by Colon Cancer Cells

1998 • 127 citations

Angiostatin: an endogenous inhibitor of angiogenesis and of tumor growth.

1997 • 111 citations

Angiostatin inhibits endothelial and melanoma cellular invasion by blocking matrix-enhanced plasminogen activation

1999 • 110 citations

Experimental and clinical studies on the use of matrix metalloproteinase inhibitors for the treatment of cancer

1996 • 106 citations

Tumour vasculature - a potential therapeutic target

1995 • 94 citations

Efficacy and Concentration-Response of Murine Anti-VEGF Monoclonal Antibody in Tumor-Bearing Mice and Extrapolation to Humans

1999 • 80 citations

Antitumor efficacy of AG3340 associated with maintenance of minimum effective plasma concentrations and not total daily dose, exposure or peak plasma concentrations

1998 • 31 citations

Angiogenesis antagonists: current clinical trials.

1998 • 21 citations

Behind the Headlines of Endostatin's Ups and Downs

1999 • 18 citations

What is all the hullabaloo about endostatin?

1999 • 12 citations

Therapeutic effects of the angiogenesis inhibitor TNP-470 against carcinomatous peritonitis in mice

1995 • 11 citations

Cancer ‘cure’ article stirs up hot debate

1998 • 3 citations

Gristle for the mill

1999 • 2 citations