Genomic alterations in distal bile duct carcinoma by comparative genomic hybridization and karyotype analysis

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

Comparative Genomic Hybridization for Molecular Cytogenetic Analysis of Solid Tumors

1992 • 3,344 citations

DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1

1996 • 2,320 citations

Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes

1988 • 2,121 citations

Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma

1994 • 1,142 citations

Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA.

1996 • 785 citations

Tumor-suppressive pathways in pancreatic carcinoma.

1997 • 689 citations

K-ras oncogene activation in adenocarcinoma of the human pancreas. A study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and allele-specific oligonucleotide hybridization.

1993 • 656 citations

Periampullary Adenocarcinoma

1998 • 391 citations

Multiple K-ras codon 12 mutations in cholangiocarcinomas demonstrated with a sensitive polymerase chain reaction technique.

1991 • 336 citations

Allelotype of pancreatic adenocarcinoma using xenograft enrichment.

1995 • 308 citations

Alterations in pancreatic, biliary, and breast carcinomas support MKK4 as a genetically targeted tumor suppressor gene.

1998 • 185 citations

Mutations of p16Ink4/CDKN2 and p15Ink4B/MTS2 genes in biliary tract cancers.

1995 • 158 citations

Mutations of the DPC4/Smad4 gene in biliary tract carcinoma.

1998 • 148 citations

Frequent loss of expression of the potential tumor suppressor gene DCC in ductal pancreatic adenocarcinoma.

1992 • 126 citations

Frequent gain of copy number on the long arm of chromosome 20 in human pancreatic adenocarcinoma

1997 • 125 citations

Point mutation of K-ras gene codon 12 in biliary tract tumors

1994 • 123 citations

Consistent chromosome abnormalities in adenocarcinoma of the pancreas.

1995 • 121 citations

Genetic analysis of ovarian germ cell tumors by comparative genomic hybridization.

1998 • 98 citations

Chromosome abnormalities in pancreatic adenocarcinoma

1994 • 66 citations

Chromosomal breakpoints in cholangiocarcinoma cell lines

1990 • 54 citations

Diagnostic and prognostic value of incidence of k-ras codon 12 mutations in resected distal bile duct carcinoma

1998 • 35 citations

Abnormal karyotypes in three carcinomas of the gallbladder

1994 • 8 citations