Vascular endothelial cell killing by combinations of membrane-active agents and hydrogen peroxide

Oxygen radicals mediate endothelial cell damage by complement-stimulated granulocytes. An in vitro model of immune vascular damage.

1978 • 1,117 citations

Mechanisms of oxidant-mediated cell injury. The glycolytic and mitochondrial pathways of ADP phosphorylation are major intracellular targets inactivated by hydrogen peroxide.

1988 • 614 citations

Hepatic Microsomal Ethanol Oxidation

1972 • 603 citations

Role of hydrogen peroxide in neutrophil-mediated destruction of cultured endothelial cells.

1981 • 587 citations

Extracellular cytolysis by activated macrophages and granulocytes. II. Hydrogen peroxide as a mediator of cytotoxicity.

1979 • 538 citations

Evidence for role of hydroxyl radical in complement and neutrophil-dependent tissue injury.

1983 • 338 citations

Neutrophil-mediated tumor cell cytotoxicity: role of the peroxidase system.

1975 • 317 citations

Two monokines, interleukin 1 and tumor necrosis factor, render cultured vascular endothelial cells susceptible to lysis by antibodies circulating during Kawasaki syndrome.

1986 • 275 citations

Alterations in adenosine triphosphate and energy charge in cultured endothelial and P388D1 cells after oxidant injury.

1985 • 268 citations

Streptococcal toxins (streptolysin O, streptolysin S, erythrogenic toxin)

1980 • 266 citations

Isolation and Culture of Pulmonary Artery Endothelial Cells

1978 • 265 citations

Pulmonary endothelial cell killing by human neutrophils. Possible involvement of hydroxyl radical.

1985 • 262 citations

Neutrophils Kill Pulmonary Endothelial Cells by a Hydrogen-Peroxide-Dependent Pathway

1984 • 213 citations

Polymorphonuclear leukocyte-mediated cell and tissue injury: Oxygen metabolites and their relations to human disease

1985 • 197 citations

A Reevaluation of the Roles of the O2-Dependent and O2-Independent Microbicidal Systems of Phagocytes

1983 • 143 citations

Tumor necrosis factor enhances susceptibility of vascular endothelial cells to neutrophil-mediated killing.

1988 • 90 citations

Synergism between eosinophil cationic protein and oxygen metabolites in killing of schistosomula of Schistosoma mansoni.

1987 • 87 citations

Neutrophil Killing of Bacteria by Oxygen-Independent Mechanisms: A Historical Summary

1985 • 73 citations

Synergistic cytolysis mediated by hydrogen peroxide combined with peptide defensins

1988 • 68 citations

Hydrogen peroxide and cytolytic factor can interact synergistically in effecting cytolysis of neoplastic targets.

1981 • 57 citations

Lysophosphatides enhance superoxide responses of stimulated human neutrophils

1989 • 57 citations

Use of microcarriers to isolate and culture pulmonary microvascular endothelium

1982 • 54 citations

Cationic polyelectrolytes: A new look at their possible roles as opsonins, as stimulators of respiratory burst in leukocytes, in bacteriolysis, and as modulators of immune-complex diseases (A review hypothesis)

1987 • 53 citations

Microvascular endothelium isolation with microcarriers: Arterial, venous

1986 • 37 citations

Poly-l-arginine and anN-formylated chemotactic peptide act synergistically with lectins and calcium ionophore to induce intense chemiluminescence and superoxide production in human blood leukocytes

1984 • 32 citations

Polyl-histidine

1987 • 28 citations

Immunofluorescence and immunocytochemistry of endothelial surface antigens

1986 • 23 citations

NADPH and ?cocktails? containing polyarginine reactivate superoxide generation in leukocytes lysed by membrane-damaging agents

1985 • 16 citations

Assay and computation of angiotensin-converting enzyme activity of endothelial cells

1986 • 10 citations