The gap junction family: structure, function and chemistry

JUNCTIONAL COMPLEXES IN VARIOUS EPITHELIA

1963 • 3,559 citations

Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia.

1986 • 1,588 citations

HEXAGONAL ARRAY OF SUBUNITS IN INTERCELLULAR JUNCTIONS OF THE MOUSE HEART AND LIVER

1967 • 1,482 citations

Junctional intercellular communication: the cell-to-cell membrane channel.

1981 • 1,268 citations

Connexin43: a protein from rat heart homologous to a gap junction protein from liver.

1987 • 1,111 citations

Surface Modulation in Cell Recognition and Cell Growth

1976 • 1,062 citations

CELL JUNCTIONS IN AMPHIBIAN SKIN

1965 • 1,001 citations

Transmission at the giant motor synapses of the crayfish

1959 • 843 citations

Molecular cloning of cDNA for rat liver gap junction protein.

1986 • 715 citations

Structure of the junction between communicating cells

1980 • 697 citations

PERMEABILITY OF MEMBRANE JUNCTIONS*

1966 • 654 citations

Hepatocyte gap junctions are permeable to the second messenger, inositol 1,4,5-trisphosphate, and to calcium ions.

1989 • 596 citations

Differential expression of three gap junction proteins in developing and mature brain tissues.

1989 • 537 citations

Antisera directed against connexin43 peptides react with a 43-kD protein localized to gap junctions in myocardium and other tissues.

1989 • 516 citations

Gap junction structures: Analysis of the x-ray diffraction data

1977 • 501 citations

Gap Junctional Conductance Is a Simple and Sensitive Function of Intracellular p H

1981 • 481 citations

Physiology and Pharmacology of Gap Junctions

1985 • 452 citations

Cloning and characterization of human and rat liver cDNAs coding for a gap junction protein.

1986 • 443 citations

Antibodies to gap-junctional protein selectively disrupt junctional communication in the early amphibian embryo

1984 • 434 citations

Segmental differentiations of cell junctions in the vascular endothelium. The microvasculature.

1975 • 430 citations

Sequence and tissue distribution of a second protein of hepatic gap junctions, Cx26, as deduced from its cDNA.

1989 • 427 citations

Size Limit of Molecules Permeating the Junctional Membrane Channels

1977 • 421 citations

Cellular basis of behavior: An introduction to behavioral neurobiology.

1976 • 379 citations

cAMP increases junctional conductance and stimulates phosphorylation of the 27-kDa principal gap junction polypeptide.

1986 • 374 citations

Two configurations of a channel-forming membrane protein

1984 • 368 citations

THE ULTRASTRUCTURE OF MAUTHNER CELL SYNAPSES AND NODES IN GOLDFISH BRAINS

1963 • 354 citations

Pogonophora in the Western Atlantic Ocean

1962 • 349 citations

Single-channel currents of an intercellular junction

1985 • 345 citations

Gap junction structures. I. Correlated electron microscopy and x-ray diffraction.

1977 • 341 citations

Comparative characterization of the 21-kD and 26-kD gap junction proteins in murine liver and cultured hepatocytes.

1989 • 341 citations

Topology of the 32-kd liver gap junction protein determined by site-directed antibody localizations.

1988 • 327 citations

Carbon dioxide reversibly abolishes ionic communication between cells of early amphibian embryo

1977 • 323 citations

Formation of gap junctions by expression of connexins in Xenopus oocyte pairs

1989 • 317 citations

Two homologous protein components of hepatic gap junctions

1987 • 284 citations

Gap junctions, electrotonic coupling, and intercellular communication.

1978 • 267 citations

Kinetic properties of a voltage-dependent junctional conductance.

1981 • 265 citations

Proteoglycans and glycosaminoglycans induce gap junction synthesis and function in primary liver cultures.

1987 • 230 citations

Structure and biochemistry of mouse hepatic gap junctions

1979 • 228 citations

Selective Disruption of Gap Junctional Communication Interferes with a Patterning Process in Hydra

1987 • 227 citations

Cell junction and cyclic AMP: I. Upregulation of junctional membrane permeability and junctional membrane particles by administration of cyclic nucleotide or phosphodiesterase inhibitor

1981 • 206 citations

Topological analysis of the major protein in isolated intact rat liver gap junctions and gap junction-derived single membrane structures.

1987 • 205 citations

THE ISOLATION OF MOUSE HEPATOCYTE GAP JUNCTIONS

1972 • 200 citations

Single-channel events and gating behavior of the cardiac gap junction channel.

1988 • 200 citations

Topological distribution of two connexin32 antigenic sites in intact and split rodent hepatocyte gap junctions.

1988 • 199 citations

Voltage Dependence of Junctional Conductance in Early Amphibian Embryos

1979 • 186 citations

A detergent-independent procedure for the isolation of gap junctions from rat liver.

1984 • 179 citations

Expression of Functional Cell-Cell Channels from Cloned Rat Liver Gap Junction Complementary DNA

1987 • 166 citations

The Gap Junction

1986 • 164 citations

Cloning and Expression of a Xenopus Embryonic Gap Junction Protein

1989 • 161 citations

Cyclic adenosine monophosphate stimulates biosynthesis and phosphorylation of the 26 kDa gap junction protein in cultured mouse hepatocytes.

1987 • 152 citations

Junctional membrane permeability

1971 • 152 citations

A protein homologous to the 27,000 dalton liver gap junction protein is present in a wide variety of species and tissues

1984 • 150 citations

Expression of gap junction channels in communication-incompetent cells after stable transfection with cDNA encoding connexin 32.

1990 • 142 citations

cAMP delays disappearance of gap junctions between pairs of rat hepatocytes in primary culture

1989 • 137 citations

Cell-to-cell channels with two independently regulated gates in series: Analysis of junctional conductance modulation by membrane potential, calcium, and pH

1983 • 134 citations

Functional assembly of gap junction conductance in lipid bilayers: Demonstration that the major 27 kd protein forms the junctional channel

1987 • 131 citations

Gating of gap junction channels

1984 • 127 citations

Gap junctions in several tissues share antigenic determinants with liver gap junctions.

1984 • 121 citations

Topology of the Mr 27,000 liver gap junction protein. Cytoplasmic localization of amino- and carboxyl termini and a hydrophilic domain which is protease-hypersensitive.

1988 • 119 citations

In vitro formation of gap junction vesicles

1976 • 115 citations

Cell junction and cyclic AMP: III. Promotion of junctional membrane permeability and junctional membrane particles in a junction-deficient cell type

1981 • 104 citations

Sequence and developmental expression of mRNA coding for a gap junction protein in Xenopus.

1988 • 103 citations

Rat liver gap junction protein: properties and partial sequence.

1981 • 98 citations

Isolation of mouse myocardial gap junctions.

1980 • 91 citations

The inside and outside of gap-junction membranes visualized by deep etching

1982 • 91 citations

Gap Junctional Conductance and Permeability Are Linearly Related

1986 • 85 citations

Isolated liver gap junctions: gating of transjunctional currents is similar to that in intact pairs of rat hepatocytes.

1986 • 81 citations

The Mr 28,000 gap junction proteins from rat heart and liver are different but related.

1985 • 76 citations

Comparative analysis of the gap junction protein from rat heart and liver: Is there a tissue specificity of gap junctions?

1983 • 69 citations

Isolation and characterisation of arthropod gap junctions

1984 • 67 citations

Immunological properties of gap junction protein from mouse liver

1982 • 52 citations

The role of junctional communication in animal tissues

1980 • 50 citations

The cardiac gap junction protein (Mr 47,000) has a tissue-specific cytoplasmic domain of Mr 17,000 at its carboxy-terminus

1987 • 50 citations

Isolation and protein composition of gap junctions from rabbit hearts

1982 • 40 citations

Identification of a rat liver cDNA and mRNA coding for the 28 kDa gap junction protein

1986 • 39 citations

Organization of connexons in isolated rat liver gap junctions

1988 • 28 citations

Three-dimensional structure of gap junctions in fragmented plasma membranes from rat liver

1988 • 20 citations

Cytoplasmic and cell surface structure of purified liver gap junctions revealed by freeze-drying.

1984 • 5 citations

Structure-activity relations of the cardiac gap junction channel: Some testable hypotheses

1990 • 2 citations