Pharmacokinetics of calcium-entry blockers

Clinical Pharmacokinetics

1975 • 427 citations

Hemodynamic consequences of combined beta-adrenergic and slow calcium channel blockade in man.

1982 • 331 citations

Clinical Pharmacokinetics

1975 • 298 citations

Pharmacokinetics and metabolism of nifedipine.

1983 • 224 citations

The influence of verapamil on serum digoxin concentration.

1982 • 207 citations

Influence of severity of ventricular dysfunction on hemodynamic responses to intravenously administered verapamil in ischemic heart disease

1981 • 198 citations

Nifedipine Kinetics and Bioavailability After Single Intravenous and Oral Doses in Normal Subjects

1983 • 194 citations

Clinical efficacy of verapamil alone and combined with propranolol in treating patients with chronic stable angina pectoris

1981 • 169 citations

The metabolism of DL-[14C]verapamil in man.

1979 • 167 citations

The effect of diltiazem and propranolol, alone and in combination, on exercise performance and left ventricular function in patients with stable effort angina: a double-blind, randomized, and placebo-controlled study.

1983 • 159 citations

Interaction between digoxin and calcium antagonists and antiarrhythmic drugs

1983 • 157 citations

Electrophysiologic and hemodynamic effects of verapamin. Correlation with plasma drug concentrations.

1978 • 150 citations

Nifedipine and propranolol: A beneficial drug interaction

1981 • 149 citations

Gas chromatographic determination of nifedipine and one of its metabolites using electron capture detection

1979 • 140 citations

The Pharmacology of verapamil. IV. Kinetic and dynamic effects after single intravenous and oral doses

1982 • 140 citations

Pharmacokinetic and pharmacodynamic effects of diltiazem

1983 • 140 citations

Combined therapy with verapamil and propranolol in chronic stable angina

1982 • 132 citations

Reflex chronotropic and inotropic effects of calcium channel-blocking agents in conscious dogs. Diltiazem, verapamil, and nifedipine compared.

1983 • 128 citations

Clinical Pharmacokinetics of Verapamil

1984 • 124 citations

Pharmacokinetics of diltiazem after intravenous and oral administration

1983 • 119 citations

Reduced verapamil clearance during long-term oral administration

1981 • 119 citations

Comparative cardiovascular actions of verapamil and its major metabolites in the anaesthetised dog

1978 • 119 citations

Pharmacokinetics, bioavailability and ECG response of verapamil in patients with liver cirrhosis.

1981 • 118 citations

Verapamil disposition kinetics in chronic atrial fibrillation

1981 • 116 citations

Verapamil kinetics in normal subjects and patients with coronary artery spasm

1981 • 113 citations

Simultaneous determination of the intravenous and oral pharmacokinetic parameters of D,L-verapamil using stable isotope-labelled verapamil

1981 • 105 citations

High-performance liquid chromatography of nifedipine, its metabolites and photochemical degradation products

1981 • 105 citations

Nifedipine and left ventricular function in beta-blocked patients.

1981 • 98 citations

High-performance liquid chromatographic analysis of verapamil. II. Simultaneous quantitation of verapamil and its active metabolite, norverapamil.

1980 • 98 citations

Effects of verapamil on P-R-intervals in relation to verapamil plasma levels following single i.v. and oral administration and during chronic treatment

1980 • 97 citations

Relationship between the antihypertensive effect and steady-state plasma concentration of nifedipine given alone or in combination with a beta-adrenoceptor blocking agent

1980 • 94 citations

High-performance liquid chromatographic analysis of verapamil

1980 • 91 citations

New therapy of ischemic heart disease

1975 • 90 citations

The long-term effect of verapamil on plasma digoxin concentration and renal digoxin clearance in healthy subjects

1982 • 89 citations

Verapamil protein binding in patients and in normal subjects

1981 • 88 citations

Pharmacokinetics of diltiazem in selected animal species and human beings

1982 • 87 citations

Acute and chronic pharmacodynamic interaction of verapamil and digoxin in atrial fibrillation.

1982 • 86 citations

The Pharmacology of Verapamil

1983 • 80 citations

Pharmacokinetic studies of nifedipine tablet. Correlation with antihypertensive effects.

1983 • 74 citations

Simple, sensitive and specific gas chromatographic method for the quantification of diltiazem in human body fluids

1977 • 74 citations

Calcium Antagonists Pharmacokinetic Properties

1983 • 72 citations

Rapid high-pressure liquid chromatographic analysis of verapamil in blood and plasma

1979 • 72 citations

Measurement of nifedipine in plasma by gas--liquid chromatography and electron-capture detection.

1983 • 70 citations

Occurrence and measurement of nifedipine and its nitropyridine derivative in human blood plasma

1982 • 66 citations

Rapid high-performance liquid chromatographic method for the measurement of verapamil and norverapamil in blood plasma or serum

1981 • 66 citations

High-performance liquid chromatographic analysis of diltiazem and its metabolite in plasma

1983 • 66 citations

Quantitative determination of nifedipine in human plasma by selected ion monitoring

1978 • 62 citations

Pharmacokinetics in Clinical Practice

1976 • 60 citations

Acute and long-term hypotensive effects and plasma concentrations of nifedipine in patients with essential hypertension

1982 • 59 citations

Verapamil plasma binding: Relationship to α1-acid glycoprotein and drug efficacy

1983 • 56 citations

Digoxin-diltiazem interaction

1984 • 55 citations

Verapamil and digoxin: Their respective effects on atrial fibrillation and their interaction

1982 • 55 citations

Acute antihypertensive effect and pharmacokinetics of a tablet preparation of nifedipine

1983 • 51 citations

Pharmacokinetics of diltiazem in severe renal failure

1983 • 50 citations

The Pharmacokinetics and Pharmacology of Oral Diltiazem in Normal Volunteers

1981 • 49 citations

Effect of nifedipine on digoxin kinetics in healthy subjects

1982 • 48 citations

Effect of Hypothermia on Drug Metabolism

1980 • 46 citations

Pharmacokinetics in clinical practice

1985 • 45 citations

Pharmacokinetics in Clinical Practice

1976 • 44 citations

Epinephrine-induced Arrhythmias and Cardiovascular Function after Verapamil during Halothane Anesthesia in the Dog

1981 • 44 citations

Pharmacokinetics and bioavailability of diltiazem (CRD-401) in dog.

1977 • 43 citations

Calcium-entry blockade, beta-adrenergic blockade and the reflex control of circulation.

1982 • 43 citations

Serum Binding of Diltiazem in Humans

1982 • 39 citations

Analysis of verapamil in plasma by liquid chromatography

1980 • 39 citations

Hemodynamic Interactions of Verapamil and Isoflurane

1983 • 39 citations

Clinical Pharmacokinetics of Calcium Channel Antagonists

1982 • 37 citations

Clinical pharmacokinetics of verapamil in patients with atrial fibrillation

1982 • 31 citations

Factors affecting the plasma protein binding of verapamil and norverapamil in man.

1980 • 26 citations

Hemodynamic Responses to Nifedipine in Dogs Anesthetized with Halothane

1983 • 23 citations

Measurement of Verapamil Concentrations in Plasma by Gas Chromatography and High Pressure Liquid Chromatography

1980 • 22 citations

Gas-chromatographic determination of verapamil and norverapamil, with a nitrogen-selective detector.

1982 • 21 citations

Investigations on the Metabolism and Protein Binding of Nifedipine

1975 • 20 citations

Relationship Between Plasma Diltiazem and Cardiovascular Responses in Conscious Dogs

1983 • 20 citations

Interaction Between Negative Inotropic Effects of Halothane and Nifedipine in the Isolated Rat Heart

1983 • 18 citations

Plasma Concentrations and Hemodynamic Effects of Nifedipine

1983 • 17 citations

Effects of Phenobarbital and SKF-525A on in vitro Hepatic Metabolism of Verapamil and Nifedipine

1985 • 12 citations

Mass spectrometric identification of DL-verapamil metabolites.

1980 • 10 citations

Lack of Correlation of Verapamil Plasma Level with Cumulative Protective Effects Against Halothane—Epinephrine Ventricular Arrhythmias

1982 • 7 citations

Pharmacodynamic Comparison of Verapamil and Nifedipine in Anesthetized Dogs

1985 • 5 citations

Effects of Verapamil on the Arrhythmogenic Action of Acetylstrophanthidin

1984 • 4 citations