Using mouse models to dissect the genetics of obesity

Positional cloning of the mouse obese gene and its human homologue

1994 • 12,975 citations

Central nervous system control of food intake

2000 • 6,305 citations

Obesity as a medical problem

2000 • 4,948 citations

Identification and expression cloning of a leptin receptor, OB-R

1995 • 3,498 citations

Congenital leptin deficiency is associated with severe early-onset obesity in humans

1997 • 2,900 citations

Role of Brain Insulin Receptor in Control of Body Weight and Reproduction

2000 • 2,178 citations

Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of Ikkβ

2001 • 1,849 citations

A Transgenic Model of Visceral Obesity and the Metabolic Syndrome

2001 • 1,743 citations

Towards a molecular understanding of adaptive thermogenesis

2000 • 1,560 citations

Genetic Ablation of Orexin Neurons in Mice Results in Narcolepsy, Hypophagia, and Obesity

2001 • 1,387 citations

Increased Energy Expenditure, Decreased Adiposity, and Tissue-Specific Insulin Sensitivity in Protein-Tyrosine Phosphatase 1B-Deficient Mice

2000 • 1,218 citations

Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat

2000 • 885 citations

A Twin Study of Human Obesity

1986 • 872 citations

Genome-wide, large-scale production of mutant mice by ENU mutagenesis

2000 • 681 citations

Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity

1995 • 669 citations

A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse

2000 • 661 citations

Quantitative trait loci on chromosomes 3 and 17 influence phenotypes of the metabolic syndrome

2000 • 638 citations

Melanin-concentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance

2001 • 617 citations

Advanced intercross lines, an experimental population for fine genetic mapping.

1995 • 586 citations

Absence of perilipin results in leanness and reverses obesity in Leprdb/db mice

2000 • 577 citations

Experimental strategies for the genetic dissection of complex traits in animal models

1998 • 553 citations

Targeted disruption of inducible nitric oxide synthase protects against obesity-linked insulin resistance in muscle

2001 • 536 citations

An Autosomal Genomic Scan for Loci Linked to Type II Diabetes Mellitus and Body-Mass Index in Pima Indians

1998 • 484 citations

Analysing complex genetic traits with chromosome substitution strains

2000 • 467 citations

Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation.

1993 • 428 citations

Quantitative trait loci in Drosophila

2001 • 427 citations

Profound obesity associated with a balanced translocation that disrupts the SIM1 gene

2000 • 396 citations

A genome-wide scan for human obesity genes reveals a major susceptibility locus on chromosome 10

1998 • 385 citations

Identification and Characterization of the Mouse Obesity Gene tubby: A Member of a Novel Gene Family

1996 • 366 citations

Quantitative Trait Loci for Murine Growth

1996 • 326 citations

Improved Glucose and Lipid Metabolism in Genetically Obese Mice Lacking aP2

2000 • 304 citations

Identification of an obesity quantitative trait locus on mouse chromosome 2 and evidence of linkage to body fat and insulin on the human homologous region 20q.

1997 • 232 citations

Rodent obesity models: An overview

2001 • 220 citations

The mouse mahogany locus encodes a transmembrane form of human attractin

1999 • 205 citations

Mapping quantitative trait loci for murine growth: a closer look at genetic architecture

1999 • 190 citations

Identification of four chromosomal loci determining obesity in a multifactorial mouse model.

1995 • 182 citations

Disruption of the plasminogen activator inhibitor‐1 gene reduces the adiposity and improves the metabolic profile of genetically obese and diabetic ob/ob mice

2001 • 170 citations

A Genome-Wide Scan for Abdominal Fat Assessed by Computed Tomography in the Québec Family Study

2001 • 156 citations

Genetic architecture of adiposity in the cross of LG/J and SM/J inbred mice

2001 • 154 citations

Dietary obesity linked to genetic loci on chromosomes 9 and 15 in a polygenic mouse model.

1994 • 151 citations

THE AETIOLOGY OF OBESITY IN CHILDREN A Study of 101 Twin Pairs

1976 • 138 citations

Fine mapping of trypanosomiasis resistance loci in murine advanced intercross lines

2000 • 138 citations

Recent advances: Recent advances in the genetics of severe childhood obesity

2000 • 137 citations

Genetic loci controlling body fat, lipoprotein metabolism, and insulin levels in a multifactorial mouse model.

1998 • 134 citations

Single QTL Effects, Epistasis, and Pleiotropy Account for Two-thirds of the Phenotypic F2 Variance of Growth and Obesity in DU6i x DBA/2 Mice

2000 • 134 citations

Quantitative Trait Loci Affecting Body Weight and Fatness From a Mouse Line Selected for Extreme High Growth

1998 • 133 citations

Protection From Obesity in Mice Lacking the VLDL Receptor

2001 • 131 citations

Dietary obesity in the mouse: interaction of strain with diet composition

1995 • 121 citations

Genetics of dietary obesity in AKR/JxSWR/J mice: segregation of the trait and identification of a linked locus on Chromosome 4

1994 • 110 citations

Capitalizing on large-scale mouse mutagenesis screens

2000 • 102 citations

Susceptibility to testicular germ-cell tumours in a 129.MOLF-Chr 19 chromosome substitution strain

1999 • 100 citations

Identification of Quantitative Trait Loci Influencing Traits Related to Energy Balance in Selection and Inbred Lines of Mice

1999 • 94 citations

A genetic analysis of weight and overweight in 4-year-old twin pairs

2001 • 89 citations

Multiple obesity QTLs identified in an intercross between the NZO (New Zealand obese) and the SM (small) mouse strains

2001 • 88 citations

Mapping of obesity QTLs in a cross between mouse lines divergently selected on fat content

2000 • 85 citations

Genetic dissection of obesity in polygenic animal models.

1997 • 84 citations

Genetic variation in body weight gain and composition in the intercross of Large (LG/J) and Small (SM/J) inbred strains of mice

1998 • 82 citations

Synergistic Gene Interactions Control the Induction of the Mitochondrial Uncoupling Protein (Ucp1) Gene in White Fat Tissue

2000 • 77 citations

Gender-influenced obesity QTLs identified in a cross involving the KK type II diabetes-prone mouse strain

1999 • 70 citations

Inbred lines of mice derived from long-term growth selected lines: unique resources for mapping growth genes

2001 • 65 citations

Sensitivity to dietary obesity linked to a locus on Chromosome 15 in a CAST/Ei × C57BL/6J F2 intercross

1996 • 62 citations

A Genome-Wide Scan for Obesity in African-Americans

2002 • 61 citations

Knockout models resulting in the development of obesity

2001 • 58 citations

Quantitative trait loci for growth traits in C57BL/6J × DBA/2J mice

1999 • 52 citations

Inbred lines of mice derived from long-term divergent selection on fat content and body weight

1999 • 47 citations

Inherited non-autosomal effects on body fat in F 2 mice derived from an AKR/J × SWR/J cross

1997 • 44 citations

Distribution of Body Weight, Blood Insulin and Lipid Levels in the SMXA Recombinant Inbred Strains and the QTL Analysis.

2000 • 44 citations

Altering Developmental Trajectories in Mice by Restricted Index Selection

1997 • 43 citations

Mapping quantitative trait loci for body weight on the X chromosome in mice. I. Analysis of a reciprocal F₂ population

1997 • 40 citations

Gene-environment interaction: a significant diet-dependent obesity locus demonstrated in a congenic segment on mouse Chromosome 7 Mus castaneus. -->

1999 • 34 citations

Quantitative Trait Loci for Body Weight in the Intercross between SM/J and A/J Mice.

2001 • 28 citations

High-resolution quantitative trait locus mapping for body weight in mice by recombinant progeny testing

2001 • 25 citations

Mapping quantitative trait loci for body weight on the X chromosome in mice. II. Analysis of congenic backcrosses

1997 • 24 citations

Segregation Analysis of Body Mass Index in a Large Sample Selected for Obesity: The Swedish Obese Subjects Study

1999 • 24 citations

Transgenic mice overexpressing γ-aminobutyric acid transporter subtype I develop obesity

2000 • 23 citations

Genetics and physiology of dietary obesity in the mouse.

1996 • 7 citations