Effects of inducers and inhibitors on the metabolism of aflatoxin B, by rat and mouse

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Toxicity associated with Certain Samples of Groundnuts

1961 • 503 citations

Liver microsomal metabolism of aflatoxin B 1 to a reactive derivative toxic to Salmonella typhimurium TA 1530.

1972 • 415 citations

Aryl hydrocarbon (benzo[a]pyrene) hydroxylase in microsomes from rat tissues: Differential inhibition and stimulation by benzoflavones and organic solvents

1971 • 374 citations

Separation and purification of multiple forms of microsomal cytochrome P-450. Activities of different forms of cytochrome P-450 towards several compounds of environmental interest.

1977 • 367 citations

Studies on the induction of CO-binding pigments in liver microsomes by phenobarbital and 3-methylcholanthrene

1967 • 334 citations

Multiple forms of rat liver cytochrome P-450. Immunochemical evidence with antibody against cytochrome P-448.

1976 • 262 citations

2,3-Dihydro-2-(guan-7-yl)-3-hydroxy-aflatoxin B1, a major acid hydrolysis product of aflatoxin B1-DNA or -ribosomal RNA adducts formed in hepatic microsome-mediated reactions and in rat liver in vivo.

1977 • 260 citations

Genetic expression of aryl hydrocarbon hydroxylase activity in the mouse

1975 • 245 citations

Induction of multiple forms of mouse liver cytochrome P-450. Evidence for genetically controlled de novo protein synthesis in response to treatment with beta-naphthoflavone or phenobarbital.

1976 • 229 citations

Aflatoxin B1-2,3-oxide: Evidence for its formation in rat liver in vivo and by human liver microsomes in vitro

1974 • 213 citations

HISTOCHEMICAL DEMONSTRATION OF REDUCED PYRIDINE NUCLEOTIDE DEPENDENT POLYCYCLIC HYDROCARBON METABOLIZING SYSTEMS

1962 • 210 citations

Cigarette Smoking: Stimulatory Effect on Metabolism of 3,4-Benzpyrene by Enzymes in Human Placenta

1968 • 194 citations

HEPATITIS-ASSOCIATED ANTIGEN IN UGANDAN PATIENTS WITH HEPATOCELLULAR CARCINOMA

1970 • 193 citations

Aflatoxin B ₁ : Binding to DNA in vitro and Alteration of RNA Metabolism in vivo

1966 • 184 citations

Structure-activity relationships in toxicity and carcinogenicity of aflatoxins and analogs.

1971 • 172 citations

Separation, purification, and properties of multiple forms of cytochrome P-450 from the liver microsomes of phenobarbital-treated mice.

1976 • 159 citations

Aryl Hydrocarbon (Benzopyrene) Hydroxylase Is Stimulated in Human Lymphocytes by Mitogens and Benz[a]anthracene

1972 • 139 citations

Gel electrophoresis of partially purified cytochromes P450 from liver microsomes of variously-treated rats

1973 • 136 citations

2,3-Dihydro-2,3-dihydroxy-aflatoxin B1: An acid hydrolysis product of an RNA-aflatoxin B1 adduct formed by hamster and rat liver microsomes in vitro

1973 • 128 citations

Hepatic cirrhosis: A clinico-pathological review of 520 cases

1973 • 126 citations

Dependence of specific metabolism of benzo(a)pyrene on the inducer of hydroxylase activity.

1974 • 105 citations

Differences in the kinetics of benzpyrene hydroxylation by hepatic drug-metabolizing enzymes from phenobarbital and 3-methylcholanthrene-treated rats

1968 • 105 citations

Immunochemical studies on two electrophoretically homogeneous forms of rabbit liver microsomal cytochrome P-450: P-450LM2 and P-450LM4.

1977 • 90 citations

Induction of Benzo[α]pyrene Hydroxylase in Human Skin

1972 • 88 citations

Dietary aflatoxins and human liver cancer. I. Toxigenic moulds in foods and foodstuffs of tropical south-east asia

1972 • 79 citations

In vitro metabolic conversion of aflatoxins and benzo(alpha)pyrene to nucleic acid-binding metabolites.

1975 • 72 citations

Partial purification and properties of cytochromes P-450 and P-448 from rat liver microsomes

1972 • 72 citations

Species comparison of in vitro metabolism of aflatoxin B1.

1977 • 65 citations

Hepatic microsomal mixed function oxygenase: Enzyme multiplicity for the metabolism of carcinogens to DNA-binding metabolites

1974 • 61 citations

Reduced nicotinamide adenine dinucleotide phosphate-dependent formation of 2,3-dihydro-2,3-dihydroxyaflatoxin B1 from aflatoxin B1 by hepatic microsomes.

1978 • 58 citations

Characterization of benzo(a)pyrene hydroxylase of trout liver.

1977 • 58 citations

Mapping the adrenal lipid depletion gene of the AKR/J mouse strain

1975 • 54 citations

Metabolic activation of aflatoxins related to their mutagenicity

1978 • 52 citations

Further Studies on Genetically Mediated Differences in Monooxygenase Activities and Spin State of Cytochrome P450 Iron from Rabbit, Rat, and Mouse Liver

1973 • 47 citations

Hepatitis-associated antigen in liver disease in Kenya.

1971 • 46 citations

INDUCIBLE MONOOXYGENASE ACTIVITIES AND 3-METHYLCHOLANTHRENE-INITIATED TUMORIGENESIS IN MOUSE RECOMBINANT INBRED SUBLINES

1976 • 40 citations

Interactions of Aflatoxin with Histones and DNA

1967 • 40 citations

Association and dissociation of the Ah locus with the metabolism of aflatoxin B1 by mouse liver. Co-segregation of aflatoxin B1 hydroxylase induction with aryl hydrocarbon (benzo(a)pyrene) hydroxylase induction.

1978 • 38 citations

Effect of 17-β-estradiol and testosterone on aryl hydrocarbon hydroxylase activity in mouse tissuesin vivo and in cell culture

1970 • 33 citations

A kinetic approach to a study of the induction of rat liver microsomal hydroxylase after pretreatment with 3,4-benzpyrene and aflatoxin B1

1970 • 29 citations

Differences in the effect of phenobarbital treatment on the in vitro metabolism of aflatoxin and aniline by duck and rat livers

1971 • 25 citations

Multiplicity of Liver Microsomal Cytochrome P-450: Separation, Purification and Characterization

1976 • 24 citations

Microsome-dependent binding of benzo(alpha)pyrene and aflatoxin B1 to DNA, and benzo(alpha)pyrene binding to aflatoxin-conjugated DNA.

1974 • 17 citations

Genetics of aryl hydrocarbon hydroxylase induction in mice: Response of the lung to cigarette smoke and 3-methylcholanthrene

1977 • 8 citations

Simple vs. complex inheritance of inducible aryl hydrocarbon hydroxylase in mouse tissues

1975 • 7 citations