Pharmacodynamic Monitoring of Cyclosporin

Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin

1986 • 2,137 citations

Cyclophilin: A Specific Cytosolic Binding Protein for Cyclosporin A

1984 • 1,670 citations

Biological effects of cyclosporin A: A new antilymphocytic agent

1976 • 1,501 citations

Contingent Genetic Regulatory Events in T Lymphocyte Activation

1989 • 1,108 citations

Effects of the new anti-lymphocytic peptide cyclosporin A in animals.

1977 • 710 citations

Isolation of a membrane-bound cofactor for thrombin-catalyzed activation of protein C.

1982 • 709 citations

Purification to homogeneity and characterization of human B-cell differentiation factor (BCDF or BSFp-2).

1985 • 679 citations

Cyclosporin A inhibits T-cell growth factor gene expression at the level of mRNA transcription.

1984 • 623 citations

Clinical Pharmacokinetics of Cyclosporin

1986 • 488 citations

Induction of Interleukin 2 Messenger RNA Inhibited by Cyclosporin A

1984 • 404 citations

IL-6/BSF-2 functions as a killer helper factor in the in vitro induction of cytotoxic T cells.

1988 • 365 citations

Human B-cell differentiation factor defined by an anti-peptide antibody and its possible role in autoantibody production.

1987 • 363 citations

Thrombomodulin is present in human plasma and urine.

1985 • 295 citations

Lymphokine and nonlymphokine mRNA levels in stimulated human T cells. Kinetics, mitogen requirements, and effects of cyclosporin A.

1986 • 293 citations

Human lymphotoxin. Production by a lymphoblastoid cell line, purification, and initial characterization.

1984 • 284 citations

INDIVIDUALIZATION OF CYCLOSPORINE THERAPY USING PHARMACOKINETIC AND PHARMACODYNAMIC PARAMETERS

1985 • 278 citations

Soluble IL-2 receptor in rheumatoid arthritis. Correlation with disease activity, IL-1 and IL-2 inhibition.

1988 • 274 citations

Interleukin 6 (IL-6) in serum and urine of renal transplant recipients.

1988 • 265 citations

Endothelial Cells and the Biology of Factor VIII

1977 • 252 citations

Effect of cyclosporin A on human lymphocyte responses in vitro. I. CsA allows for the expression of alloantigen-activated suppressor cells while preferentially inhibiting the induction of cytolytic effector lymphocytes in MLR.

1980 • 239 citations

β2-microglobulin: Its significance in the evaluation of renal function

1987 • 239 citations

Critical issues in cyclosporine monitoring: report of the Task Force on Cyclosporine Monitoring.

1987 • 233 citations

Increased Factor VIII/von Willebrand Factor Antigen and von Willebrand Factor Activity in Scleroderma and in Raynaud's Phenomenon

1981 • 220 citations

OPTIMIZATION OF CYCLOSPORINE THERAPY IN RENAL TRANSPLANTATION BY A PHARMACOKINETIC STRATEGY

1988 • 193 citations

Pharmacology of cyclosporine (sandimmune). IV. Pharmacological properties in vivo.

1990 • 174 citations

Effect of cyclosporin A and dexamethasone on interleukin 2 receptor gene expression.

1986 • 171 citations

Consensus document: Hawk's Cay meeting on therapeutic drug monitoring of cyclosporine.

1990 • 149 citations

IMMUNOLOGICAL AND PHARMACOLOGICAL MONITORING IN THE CLINICAL USE OF CYCLOSPORIN A

1981 • 141 citations

Establishment of Enzyme Immunoassay of Human Thrombomodulin in Plasma and Urine Using Monoclonal Antibodies

1990 • 140 citations

Serum Cyclosporine Concentration and Risk of Acute Graft-versus-Host Disease after Allogeneic Marrow Transplantation

1988 • 126 citations

Soluble interleukin 2 receptor molecules in the serum of patients with autoimmune diseases

1989 • 121 citations

Cyclosporin A in Severe, Treatment-Refractory Rheumatoid Arthritis

1988 • 121 citations

THE RELATIONSHIP BETWEEN CYCLOSPORINE PHARMACOKINETIC PARAMETERS AND SUBSEQUENT ACUTE REJECTION IN RENAL TRANSPLANT RECIPIENTS

1988 • 113 citations

Use of β2 microglobulin to diagnose tubulo-interstitial renal lesions in children

1986 • 107 citations

Altered Factor VIII in Acute Respiratory Failure

1982 • 105 citations

Cyclosporine Nephrotoxicity: Pathogenesis, Prophylaxis, Therapy, and Prognosis

1986 • 100 citations

B-cell stimulatory factors (BSFs): Molecular structure, biological function, and regulation of expression

1987 • 100 citations

URINE i-TXB2 IN RENAL ALLOGRAFT REJECTION

1981 • 99 citations

IMMUNOPHARMACOLOGICAL MONITORING OF CYCLOSPORIN A-TREATED RECIPIENTS OF CADAVERIC KIDNEY ALLOGRAFTS

1982 • 98 citations

Inhibition of Interferon-Gamma May Suppress Allograft Reactivity by T Lymphocytes in Vitro and in Vivo

1985 • 94 citations

CYCLOPHILIN, A PRIMARY MOLECULAR TARGET FOR CYCLOSPORINE

1988 • 90 citations

Biotransformation and distribution in blood of cyclosporine and its metabolites.

1986 • 89 citations

In situ hybridization for interleukin 2 and interleukin 2 receptor mRNA in T cells activated in the presence or absence of cyclosporin A.

1988 • 86 citations

Subcellular localization of renal kallikrein by ultrastructural immunocytochemistry

1985 • 84 citations

INCREASED FACTOR VIII AS AN INDEX OF VASCULAR INJURY IN CYCLOSPORINE NEPHROTOXICITY

1986 • 83 citations

Effects of cyclosporin A on the immune system of the mouse. I. Evidence for a direct selective effect of cyclosporin A on B cells responding to anti‐immunoglobulin antibodies

1982 • 77 citations

Advances in cyclosporine pharmacology, measurement, and therapeutic monitoring.

1989 • 74 citations

Selective inhibition of immunoregulatory cell functions by cyclosporin A.

1982 • 74 citations

Pharmacology of cyclosporine (sandimmune). V. Pharmacological effects on immune function: in vitro studies.

1990 • 73 citations

Renal side-effects of cyclosporin A

1990 • 73 citations

SEQUENTIAL DETERMINATIONS OF URINARY CYTOLOGY AND PLASMA AND URINARY LYMPHOKINES IN THE MANAGEMENT OF RENAL ALLOGRAFT RECIPIENTS

1989 • 71 citations

SOLUBLE INTERLEUKIN-2 RECEPTOR LEVEL AS AN INDICATOR OF LIVER ALLOGRAFT REJECTION

1989 • 68 citations

Pharmacology and pharmacokinetics of cyclosporine

1991 • 65 citations

Adverse Reactions and Interactions of Cyclosporin

1988 • 61 citations

Cyclosporine: Structure, Pharmacokinetics, and Therapeutic Drug Monitoring

1987 • 59 citations

Therapeutic Drug Monitoring of Cyclosporin

1989 • 57 citations

Chronic Renal Tubular Effects in Relation to Urine Cadmium Levels

1989 • 56 citations

THE EFFECT OF ANTI-INTERLEUKIN-2 RECEPTOR MONOCLONAL ANTIBODY ON ALLOGRAFT REJECTION

1985 • 49 citations

Interleukin-6 serum levels correlate with footpad swelling in adjuvant-induced arthritic lewis rats treated with cyclosporin A or indomethacin

1990 • 46 citations

The role of interleukin 2 in inducing Ig production in a pokeweed mitogen-stimulated mononuclear cell system.

1987 • 45 citations

PHARMACODYNAMIC ASSESSMENT OF THE IN VIVO CYCLOSPORINE EFFECT ON INTERLEUKIN-2 PRODUCTION BY LYMPHOCYTES IN KIDNEY TRANSPLANT RECIPIENTS

1985 • 43 citations

Comparative study of serum amyloid-related protein SAA, C-reactive protein, and beta 2-microglobulin as markers of renal allograft rejection.

1984 • 43 citations

EFFECTS OF CYCLOSPORINE ON THE IMMUNE SYSTEM OF THE MOUSE II. CYCLOSPORINE INHIBITS THE EFFECTOR FUNCTION OF PRIMARY T HELPER CELLS, BUT NOT HELPER CELL PRIMING

1983 • 43 citations

Cyclosporine A: a clinical evaluation of drug interactions.

1986 • 43 citations

The value of serial serum trough cyclosporine levels in human renal transplantation.

1984 • 42 citations

SEQUENTIAL DETERMINATIONS OF SERUM INTERLEUKIN 6 LEVELS AS AN IMMUNODIAGNOSTIC TOOL TO DIFFERENTIATE REJECTION FROM NEPHROTOXICITY IN RENAL ALLOGRAFT RECIPIENTS

1991 • 41 citations

The Fluid Phase of Coagulation and the Accelerated Atherosclerosis of Diabetes Mellitus

1981 • 40 citations

Morphologic diagnosis of cyclosporine nephrotoxicity.

1988 • 39 citations

MOLECULAR CHARACTERISTICS OF CYCLOPHILIN-CYCLOSPORINE INTERACTION

1988 • 38 citations

Diagnostic significance of some urinary enzymes for detecting acute rejection crises in renal-transplant recipients: alanine aminopeptidase, alkaline phosphatase, gamma-glutamyltransferase, N-acetyl-beta-D-glucosaminidase, and lysozyme.

1986 • 32 citations

INFLUENCE OF IN VIVO IMMUNOSUPPRESSIVE DRUGS ON PRODUCTION OF LYMPHOKINES

1985 • 32 citations

IMMUNOPHARMACODYNAMIC EVALUATION OF CYCLOSPORINE-TREATED RENAL ALLOGRAFT RECIPIENTS

1984 • 28 citations

DIAGNOSIS OF TUBULAR INJURY IN RENAL TRANSPLANT PATIENTS BY A URINARY ASSAY FOR A PROXIMAL TUBLAR ANTIGEN, THE ADENOSINE-DEAMINASE-BINDING PROTEIN

1986 • 28 citations

A study of the correlation between cyclophilin binding and in vitro immunosuppressive activity of cyclosporine A and analogues.

1988 • 27 citations

Renal effects of cyclosporine

1990 • 27 citations

Pharmacokinetics and pharmacodynamics of cyclosporine.

1989 • 25 citations

Urine immunoreactive thromboxane B2 in rat cardiac allograft rejection.

1985 • 25 citations

Renal side-effects of cyclosporine.

1990 • 25 citations

Cyclosporine--mechanism of action.

1988 • 25 citations

Immunologic parameters of response in patients with rheumatoid arthritis treated with cyclosporin a

1990 • 24 citations

The cellular target of cyclosporin A action in humans.

1982 • 24 citations

INTERLEUKIN 2, INTERFERON, AND LYMPHOTOXIN IN RENAL TRANSPLANT RECIPIENTS1 Pressented at the 6th Annual Meeting of the American Society of Transplant Physicians, May 1987, Chicago, IL

1988 • 23 citations

EVIDENCE THAT THE SOLUBLE INTERLEUKIN 2 RECEPTOR LEVEL MAY DETERMINE THE OPTIMAL TIME FOR CYSTOSCOPICALLY-DIRECTED BIOPSY IN PANCREATICODUODENAL ALLOGRAFT RECIPIENTS

1990 • 22 citations

Pharmacology of cyclosporine (sandimmune). III. Immunochemistry and monitoring.

1990 • 21 citations

IMMUNE MECHANISMS IN ORGAN ALLOGRAFT REJECTION: VI. DELAYED-TYPE HYPERSENSITIVITY AND LYMPHOTOXIN IN EXPERIMENTAL RENAL ALLOGRAFT REJECTION

1985 • 21 citations

Significance of cyclosporine pharmacokinetics.

1988 • 19 citations

Urinary and aminopeptidase N in the diagnosis of graft rejection after live donor renal transplantation

1985 • 18 citations

Plasma thrombomodulin levels as an indicator of vascular injury caused by cyclosporine nephrotoxicity.

1990 • 18 citations

Prediction of acute graft rejection in renal transplantation: the utility of cyclosporine blood concentrations.

1991 • 18 citations

Indicators of acute renal-transplant rejection in patients treated with cyclosporine

1990 • 18 citations

Cyclosporine nephrotoxicity: exploration of the risk factors and prognosis of the renal injury.

1985 • 17 citations

Area-Under-the-Curve Monitoring of Cyclosporine Therapy

1990 • 17 citations

Cyclosporin A and prednisolone do not inhibit the expression of high-affinity receptors for interleukin 2.

1988 • 17 citations

Urinary enzyme analysis in renal allograft transplantation

1986 • 17 citations

Pharmacokinetics of cyclosporine in toxicological studies.

1986 • 16 citations

Pharmacokinetic and pharmacodynamic studies of cyclosporine in bone marrow transplantation.

1990 • 16 citations

Interleukin 2 production by peripheral blood lymphocytes in allograft recipients during acute rejection episodes

1985 • 15 citations

Sequential Interleukin 2 and Interleukin 2 Receptor Levels Distinguish Rejection From Cyclosporine Toxicity in Liver Allograft Recipients

1991 • 15 citations

Sensitivity of monocyte subpopulations to cyclosporine. Arachidonate metabolism and in vitro antigen presentation.

1988 • 15 citations

Comparison of urinary N-acetyl-β-d-glucosaminidase and urinary fibrin degradation products for diagnosis of rejection after renal transplantation

1983 • 14 citations

Cyclosporine nephrotoxicity

1989 • 14 citations

GAMMA-INTERFERON PRODUCTION CAPACITY AND T LYMPHOCYTE SUBPOPULATION AFTER ALLOGENEIC BONE MARROW TRANSPLANTATION1

1986 • 14 citations

Monitoring of cyclosporine by serial posttransplant pharmacokinetic studies in renal transplant patients.

1990 • 14 citations

A PROSPECTIVE STUDY OF THE CLINICAL UTILITY OF LYMPHOCYTE MONITORING IN THE CARDIAC TRANSPLANT RECIPIENT

1990 • 13 citations

Natural killer-cell activity, interferon-alpha2 production, and interleukin-2 production in cyclosporine-treated and conventionally immunosuppressed human allograft recipients

1986 • 13 citations

Cyclophilin binding: a receptor-mediated approach to monitoring cyclosporine immunosuppressive activity following organ transplantation.

1990 • 12 citations

Pharmacodynamics of cyclosporine.

1986 • 12 citations

Cyclosporine blood level monitoring: the early posttransplant period.

1986 • 12 citations

MONITORING OF CYCLOSPORINE THERAPY WITH IN VITRO BIOLOGICAL ASSAYS

1987 • 11 citations

Diagnostic Significance of Standardized Determination of Urinary Enzymes1 in the Practice of Human Kidney Transplantation and Renal Toxicology

2015 • 11 citations

Cyclosporin A mediated immunosuppressionin vitro: effect on high affinity interleukin-2 receptor expression and -turnover

1989 • 10 citations

Usefulness of serum interleukin 2 receptor levels in renal allograft recipients.

1992 • 8 citations

URINARY THROMBOXANE EXCRETION IN CARDIAC ALLOGRAFT REJECTION IN IMMUNOSUPPRESSED RATS

1987 • 8 citations

Interleukin-2 receptor as an immunodiagnostic tool to differentiate rejection from nephrotoxicity.

1989 • 8 citations

ANTIVIRAL ACTIVITY APPEARING IN SERUM OF RENAL TRANSPLANT RECIPIENTS

1984 • 7 citations

Pharmacodynamic assays of the immunosuppressive action of cyclosporine therapy in transplant recipients.

1987 • 7 citations

Effect of cyclosporine A on the distal nephron: the use of kallikrein as a specific morphological marker.

1990 • 6 citations

Onset and Development of Cyclosporin A Effects on Lymphocytes of Cardiac Patients Before Heart Transplantation

1990 • 4 citations

Urinary thromboxane (TxA2) reflects dose-response tissue injury in humans.

1985 • 3 citations

Refractory hypertension after renal transplantation

1989 • 2 citations

Clinical pharmacology of cyclosporine

1990 • 2 citations

Tubular markers in renal transplant patients under cyclosporine.

1990 • 1 citations

Deleted Work

1955 • 0 citations